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Richard Wheeler

@zephyris-science.bsky.social

Parasite cell biology, science and microscopes (with a garnish of computers, graphics and graphic design). Runs a research lab in the University of Edinburgh.

38 Followers  |  23 Following  |  4 Posts  |  Joined: 26.04.2025  |  1.7855

Latest posts by zephyris-science.bsky.social on Bluesky

Molecule Disarms Cellular Stress Granules Linked to ALS
YouTube video by MPI-CBG Molecule Disarms Cellular Stress Granules Linked to ALS

Watch the related Science Sketch video: youtu.be/uBpPMyVTj5c?..., created by @marionamec.bsky.social

27.05.2025 14:17 โ€” ๐Ÿ‘ 7    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Molecule Disarms Cellular Stress Granules Linked to ALS Discovery by researchers in Dresden and Edinburgh points to new understanding of the onset of ALS.

A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...

27.05.2025 14:14 โ€” ๐Ÿ‘ 23    ๐Ÿ” 6    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Dynamics and emergence of metachronal waves in the ciliary band of a metazoan larva Both natural and synthetic ciliary arrays exhibit diverse coordination patterns. Proper coordination of cilia is essential for the normal physiology of many organisms, from single cells to humans. Yet...

Very cool new study about how multiple cilia self-coordinate for swimming by @micromotility.bsky.social www.biorxiv.org/content/10.1...

27.05.2025 09:18 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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A Condensate-Modifying Compound, Put to the Test

Thank you @dereklowe.bsky.social for featuring our work in In the Pipeline (www.science.org/content/blog...). It's been 6 year journey, but we finally have a target, a mechanism and a paper! www.nature.com/articles/s41...

16.05.2025 06:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Catching crumbs from the table - Nature In the face of metahuman science, humans have become metascientists.

Having spent an afternoon developing some models with Google AI Studio, Ted Chiang seems more prescient than ever. It's only about a page, worth reading right now! www.nature.com/articles/350...

15.05.2025 15:54 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!

www.nature.com/articles/s41...

14.05.2025 14:44 โ€” ๐Ÿ‘ 20    ๐Ÿ” 8    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 1
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Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Small molecule targeting intrinsically disordered protein domains to help neurodegeneration, really great to finally have this collab with @hymanlab.bsky.social out! www.nature.com/articles/s41...

14.05.2025 13:24 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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