Check out this thread for a nice breakdown (with videos!) of some of our questions about how dyneins generate a beat, all from our new preprint:
10.11.2025 22:29 — 👍 4 🔁 0 💬 0 📌 0
Massive colab with @alanbrownhms.bsky.social and Eva Gluenz, representing an enormous amount of work by Sophia Fochler and @matthdoran.bsky.social
08.11.2025 08:45 — 👍 2 🔁 0 💬 0 📌 0
Very excited to share this one! Our comprehensive structure, genetics and biophysics dissection of which flagellar dyneins and other proteins are needed for flagella to beat and drive cells swimming behaviours: www.biorxiv.org/content/10.1...
08.11.2025 08:42 — 👍 16 🔁 6 💬 3 📌 0
TrypTag is a genome-wide database of the subcellular protein localisation in the unicellular parasite Trypanosoma brucei. The main paper describing this resource is Billington et al., 2023.
tryptag.org update now done... Now with gene annotations from the latest genome, better links to source data (on BioImage Archive www.ebi.ac.uk/biostudies/B...), fixed missing images, and better cell cycle stage examples (selected using github.com/zephyris/try...). Any problems, let me know.
08.10.2025 14:52 — 👍 1 🔁 0 💬 0 📌 0
I'm working on some server changes for tryptag.org, you might see missing data (particularly missing images)... But don't worry, it will all be up again soon!
26.09.2025 11:14 — 👍 1 🔁 0 💬 0 📌 0
Google Colab
After a hiatus, the discoba lineage-optimised Alphafold2 structure predictions are back up! Get your improved Trypanosoma and Leishmania structure predictions here. Try out the Google Colab iPython notebook (and let me know if you have any problems) colab.research.google.com/github/zephy...
20.08.2025 15:00 — 👍 1 🔁 0 💬 0 📌 0
YouTube video by MPI-CBG
Molecule Disarms Cellular Stress Granules Linked to ALS
Watch the related Science Sketch video: youtu.be/uBpPMyVTj5c?..., created by @marionamec.bsky.social
27.05.2025 14:17 — 👍 7 🔁 5 💬 0 📌 1
Molecule Disarms Cellular Stress Granules Linked to ALS
Discovery by researchers in Dresden and Edinburgh points to new understanding of the onset of ALS.
A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...
27.05.2025 14:14 — 👍 23 🔁 6 💬 2 📌 0
A Condensate-Modifying Compound, Put to the Test
Thank you @dereklowe.bsky.social for featuring our work in In the Pipeline (www.science.org/content/blog...). It's been 6 year journey, but we finally have a target, a mechanism and a paper! www.nature.com/articles/s41...
16.05.2025 06:52 — 👍 0 🔁 0 💬 0 📌 0
Catching crumbs from the table - Nature
In the face of metahuman science, humans have become metascientists.
Having spent an afternoon developing some models with Google AI Studio, Ted Chiang seems more prescient than ever. It's only about a page, worth reading right now! www.nature.com/articles/350...
15.05.2025 15:54 — 👍 2 🔁 0 💬 0 📌 0
professor at UCSF, engineer turned cell biologist, wants to know how cells solve geometry problems
Cilia and cell motility enthusiast, basal cognition, weird organisms esp protists and larvae, how do living systems compute?
Professor of Cellular & Biophysical Dynamics, Living Systems Institute, Exeter (past: DAMTP, Cambridge)
www.micromotility.com
Research, news, and commentary from Nature, the international science journal. For daily science news, get Nature Briefing: https://go.nature.com/get-Nature-Briefing
The network based at the University of Edinburgh for infectious disease researchers.
https://edinburgh-infectious-diseases.ed.ac.uk/
Medicinal chemist / chemical biologist, author of “In the Pipeline” at http://science.org/blogs/pipeline. derekb.lowe@gmail.com and on Signal at Dblowe.18
All opinions are mine; I don’t speak for my employer in any way.
Cartoonist. Head Lopper, ApocalyptiGirl, Snarlagon, Godzilla: War for Humanity.
The mission of the BSP is to advance the study of parasitology, aid communication within the community, and promote dissemination of advances in the field.
http://www.bsp.uk.net/
Group Leader/MRC CDA Fellow (Dunn School of Pathology, University of Oxford)
https://www.path.ox.ac.uk/research-group/girish-ram-mali/
More formally, the Sir William Dunn School of Pathology, University of Oxford.
More understandably, we aim to transform human health through discovery research.
More completely, https://www.path.ox.ac.uk
How do cells form tissues? Our research program spans the scales from molecules to organisms. News from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, Germany. Impressum: https://www.mpi-cbg.de/impressum
🔬Head of lab at GIMM, Lisbon. Studying host-trypanosome interactions.
I am a medical school professor and molecular biologist who studies the intricacies of human malaria parasites.
Professor and Dean of The Rockefeller University. Cell biologist in NYC. Believer in the power of science education.
Not-for-profit publisher of Development, Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open. Host of community sites the Node, preLights and FocalPlane. Supporting biologists and inspiring biology.
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
Professor, University of Edinburgh.
Science: epigenetics, variegation, heterochromatin, heteroresistance, resistance, bet hedging, fungal biology & pathogens. Pets: Airedale Terriers. Duolingo: 🇫🇷 level 61. Opinions here are my own
Prof at Edinburgh University. #Immunologist. #Inflammation, #infection, #helminths, #allergy, #metabolism and the #microbiome.
https://scholar.google.com/citations?user=gcuDni4AAAAJ&hl=en&oi=ao
Not interested in pitchfork politics of any flavour…
Structural biologist and post-doc in the Brown Lab @harvardmed. Formerly at the Lehman lab @BUMedicine.
Structural biologist studying cilia and ciliopathies.
