(GIRISH)MALI LAB

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Thank you lab neighbour :)

Thank you Karina!

Thanks Mike @mike-wieczorek.bsky.social

Thank you!

Thanks Leo!

Thanks Jack! hope all well with your postdoc. Congrats on winning best thesis prize to you too!

Thank you Fay :) long overdue a catch up!

Merci Philippe! I will see you in a few weeks to celebrate in person.

A very talented PhD student @matthew-batisio.bsky.social (sadly not in my lab!). Feel free to get in touch with him for scientific animation projects.

This animation was made by the talented @matthew-batisio.bsky.social

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

Lovely tribute to David's legacy.

Applications now open for our PhD studentship programme - Dunn School Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.

Our PhD studentship programme is officially open; pass it on

If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...

Great science and a great environment!

www.path.ox.ac.uk/news-article...

Another exciting opportunity @dunnschool.bsky.social !

Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health

Please help us find great applicants

We've had a very active summer of Cilia and Centrosome science!

We had our Annual Network meeting in London this year organised by Prof. Hannah Mitchison and Dr. Dagan Jenkins. Meeting highlights are now available to read on the network website.

www.cilianetwork.org.uk/events/annua...

Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...

And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team.

@Mohinder Pal (currently not on Bluesky)
@mike-wieczorek.bsky.social
@laurencepearl.bsky.social

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia Rezi et al. show that kinesin-3 KIF13B regulates ciliary protein content by promoting endocytic retrieval and small extracellular vesicle (EV) release of ciliary proteins while suppressing their relea...

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...

Mechanistic studies on axonemal dynein transport to motile cilia - Dunn School Over 30 groups work at the Dunn School to uncover the molecular and cellular mechanisms underlying disease. Discover which research groups are accepting students for our next round of applications.

The annual Dunn School DPhil studentship competition for 2026 is open for applications.

We have a project aimed at understanding the molecular mechanisms of ciliary dynein transport. See details below and please pass on to anyone who might be interested.

www.path.ox.ac.uk/project/mech...

Research Technician – Protein Biochemistry at University of Sussex Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Wow, amazing news! Many congratulations Roger :)

Amazing news! Congratulations Roger

🏅 Honoured, amazed and daunted to receive the Royal Society’s David Attenborough Award, following in the footsteps of Hannah Fry, Richard Wiseman, Adam Rutherford, Jonathan Van-Tam and Alice Roberts. Gulp!

Jing Ren stood at the lab bench

Excellent opportunity for a motivated Scientific Researcher to work with Jing Ren’s group in the LMB’s Neurobiology Division, investigating how the serotonin system is assembled during development.
Read more: www.nature.com/naturecareer...
Apply by 07 SEP
#ScienceJobs

PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

Excited to see this work published online at @cp-cell.bsky.social today!

www.cell.com/cell/fulltex...