(GIRISH)MALI LAB

It's comforting to know I am not the only one. Coming from a sunnier country this is a real issue for me!

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Highly recommend the Dunn School for ECR's looking to establish their independent research groups. Great place, great support across the board and great mentorship!

The Dunn School has been a great place to develop my lab's research. As an ECR, I can attest to the world class support I and my team have received at all levels. Highly recommend ECR's looking to establish their independent research group's as externally-funded fellows to apply to the open call.

Interested in gene expression? How about membrane proteins?

Both, you say?

Then here's a job you might be interested in with Warwick's newest group leader, @iqbaldulloo.bsky.social

Pass it on

Research Assistant (110702-0725) at University of Warwick Apply for the Research Assistant (110702-0725) role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.

As part of building the new lab, I am recruiting for a Research Assistant@warwicklifesci.bsky.social. Ideal for someone experienced in mammalian cell biology, biochemistry, cellular virology and eager to explore unconventional functions of signal peptidase complex.
www.jobs.ac.uk/job/DOC987/r...

Thank you Kat! and also for the ongoing support/advice :)

Thank you Ula :)

Thank you for the kind words Susan @dutcherlab.bsky.social

Thank you Kelly!

Thank you Matthew for your support and mentorship!

Delighted that our work has been recognised by the field!

Thank you Pleasie :)

Super cool new story from our lab neighbours. Congratulations to the whole team! #cilia #molecularmotors

Huge thanks to the organisers!

And it's a wrap! Until next time

Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀

Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:

journals.biologists.com/jcs/article/...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Hiro's paper is out! @hiro-cg5445.bsky.social
Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors.
Big congratulations and thank you to anyone involved!

www.nature.com/articles/s41...

Another fantastic UK Microtubule meeting in Edinburgh done - this was the 10th anniversary edition and it was great to see how the community has grown. Thank you to @jwelburn.bsky.social for pulling it all together and to @markdodding.bsky.social @carter-lab.bsky.social for helping organise.

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia The temporospatial distribution of proteins within cilia is regulated by intraflagellar transport (IFT), wherein molecular trains shuttle between the cell body and cilium. Defects in this process impair various signal-transduction pathways and cause ciliopathies. Although K63-linked ubiquitination appears to trigger protein export from cilia, the mechanisms coupling polyubiquitinated proteins to IFT remain unclear. Using a multidisciplinary approach, we demonstrate that a complex of CFAP36, a conserved ciliary protein of previously unknown function, and ARL3, a GTPase involved in ciliary import, binds polyubiquitinated proteins and links them to retrograde IFT trains. CFAP36 uses a coincidence detection mechanism to simultaneously bind two IFT subunits accessible only in retrograde trains. Depleting CFAP36 accumulates K63-linked ubiquitin in cilia and disrupts Hedgehog signaling, a pathway reliant on the retrieval of ubiquitinated receptors. These findings advance our understanding of ubiquitin-mediated protein transport and ciliary homeostasis, and demonstrate how structural changes in IFT trains achieve cargo selectivity. ### Competing Interest Statement The authors have declared no competing interest. Sara Elizabeth O'Brien Trust Postdoctoral Fellowship awarded through the Charles A. King Trust Postdoctoral Research Fellowship Program, , 8460873-01 Richard and Susan Smith Family Foundation, https://ror.org/05j95n956, National Institute of General Medical Sciences (NIGMS), , R01GM141109, R01GM143183

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

Really looking forward to sharing our science on cilia and molecular motors @dunnschool.bsky.social with researchers @izb-unibern.bsky.social.

PS: I will also be visiting the Wieczorek Lab
@mike-wieczorek.bsky.social @ethzurich.bsky.social on tuesday in case anyone wants to come say hello!

Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.

🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...

Brilliant news and hugely deserved recognition for Prof. Pleasantine Mill @cilialab.bsky.social. #cilia #rarediseases.

Our MARCH Issue is now live! 🥳

Find the link to the full issue here:
🔗 go.nature.com/41gd09d

The cover is inspired by this great article on intraflagellar transport by @gaiapigino.bsky.social and @samlacey.bsky.social
👉 go.nature.com/41fEig5

#CellBio #cilia

This is my favourite figure from the paper!

Brilliant study! congratulations to the entire team.

This was wonderful to read! An absolute tour-de-force study combining all the things I love - dynamically differentiating airway cells, proteomics, expansion microscopy and cryo-EM . And to top it off some gene therapy too! Superb stuff. Congratulations to the entire team.

An absolutely incredible opportunity to work with a fantastic new PI. From personal experience of having worked with Ferdos 10/10 highly recommend!

Love it!