Alessio Fragasso

What an amazing time at the EMBO Fellows Meeting! Honored to be part of such an inspiring community, had a lot of fun connecting with this group of incredible researchers and hear about their science. A big thank you to the #EMBO organizers! 🤩

The EMBO Fellows’ Meeting 2025 is taking place in Heidelberg, DE from 27 June–1 July. Over 100 EMBO Fellows from 30+ countries will present their projects, #network, receive #training and #mentoring, speak with EMBO Press editors and learn about new EMBO #policy and #sustainability initiatives. 🧪

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social
www.nature.com/articles/s41...
rdcu.be/epIB7

Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?

ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.

Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik

#ChooseEurope

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Webinar TOMORROW at 16:00 CET/10:00 AM EDT regarding a breakthrough Nature paper from Prof. Yifat Merbl's group. Registration if FREE! Just sign up to become an iAMPNet member and register. Use the links below!
www.iampnet.com/become-a-mem...
events.teams.microsoft.com/event/57387b...

Opinion | I Came to Study Aging. Now I’m Trapped in ICE Detention.

“There is so much beauty in what we can learn through science, in how complicated life is, and in trying to understand how it works. It’s what motivates me to wake up every morning.”

Huge congrats!! 🥳❤️👌

Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy at Newcastle University Apply for the Research Assistant/Associate - Mapping the Bacterial Cell Wall with Super-resolution Microscopy role on jobs.ac.uk, the top job board for academic positions in higher education. View det...

Postdoc position available!

This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠

Please re-post 🙏

www.jobs.ac.uk/job/DMY885/r...

💻 Apply to our beginner-friendly Boston Bioimage Analysis Course!

Get started with Python and learn to analyze fluorescence microscopy images — no coding experience required!

Fee waivers available thanks to funding from @bioimagingna.bsky.social!

🗓️ Apply June 1st!
iac.hms.harvard.edu/bobiac/2025/

We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.

Check it out and apply: ceesdekkerlab.nl/come-join-us/

RT=nice!

Tracking the evolution and persistence of antibiotic resistance in the human gut A genomic study of gut microbes during antibiotic use finds selective sweeps in a DNA gyrase gene that drive resistance.

Bacteria living in the human gut are found to evolve persistent resistance after brief exposure to antibiotics.

Factors that promote this evolution have been identified, highlighting the gut as a potential hotspot for this process.

🧪🦠

www.nature.com/articles/d41...

Out now! @biorxivpreprint.bsky.social from my PhD at #CDlab

We design, experimentally test, and simulate a library of designer FG-nucleoporins.

We identify key biophysical properties of their amino acid sequence that tune their selective barrier function.

Congrats to all co-authors! 🥳

Tissue geometry spatiotemporally drives bacterial infections Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.

Now online! Tissue geometry spatiotemporally drives bacterial infections

Does marrying a fellow scientist boost your career?
In academia, homogamous couples—where both partners are scientists—are common, especially among top achievers. But who benefits more? Let’s dive into our latest research!

Deciphering the formation of cooperative multicellular biofilms Bacterial films are a hazard throughout the healthcare system, and as antibiotic resistance increases there is an even greater imperative...

🦠 Most #bacteria form #biofilms, protective communities that resist #antibiotics.

Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies.

Read more 👉 buff.ly/YajqauG

@krastevalab.bsky.social @iecb.bsky.social @CNRS.fr

🚨We have a 4-year ERC-funded PhD position available in the beautiful city of Leuven, Belgium, for building artificial nanomachines in lipid membranes.

Check out the details and apply here: www.kuleuven.be/personeel/jo...

Feel free to email me for more information!

For the busy folks, here is an engaging podcast which I find incredibly accurate and gives a good recap of the paper, enjoy!
drive.google.com/file/d/15awG...

Thanks Mark! 🙏🤩

Time-resolved phenotyping at subcellular resolution reveals shared principles and key trade-offs across antimicrobial peptide activities Cationic antimicrobial peptides are a large family of host defense molecules with diverse sequences and structures. Here, we present a computational and experimental pipeline for quantifying the membr...

Excited to share our first big story from my postdoc @JacobsWagnerLab, now on biorxiv: biorxiv.org/content/10.1...

We build a single-cell pipeline to functionally classify antimicrobial peptides and peptidomimetics based on phenotypes

Huge thanks to Christine and coauthors! 🥳🤩