Lauritz Miarka, MD

The evolution of microglia replacement: A new paradigm for CNS disease therapy Microglia are important immune cells in the brain. Mutations in microglia cause microgliopathies. Microglia replacement has emerged as a groundbreaking therapeutic paradigm that enables correction of ...

www.cell.com/cell-stem-ce...

Advancing CNS tumor diagnostics with expanded DNA methylation-based classification Sill and colleagues present an expanded DNA methylation classifier for CNS tumors. Building upon the 2021 WHO classification, this resource introduces a hierarchical taxonomy of 184 subclasses. It enhances classification accuracy for rare entities and provides integrated genomic data from a single, streamlined assay for modern neuro-oncology.

Online Now: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

In vivo CRISPR screen reveals regulation of macrophage states in neuroinflammation @natneuro.nature.com
www.nature.com/articles/s41...

The evolving landscape of brain metastasis: volume II Brain metastasis (BrM) represents the most common intracranial malignancy, arising in up to 30% of all adult cancer patients and contributing significantly to cancer-related morbidity and mortality. B...

Volume II of The Evolving Landscape of Brain Metastasis: 17 leading figures in the field looked back and identified the most relevant discoveries since volume I, 8 years ago. The landscape is starting to look better, but still lots of things to do! www.cell.com/trends/cance...

Local B cell maturation and mast cell regulation of choroid plexus function in early life. Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Schematic figure showing divergent evolution of malignant subclones and how they migrate to different tissue compartments (blood vs skin), respond differently to extrinsic stimuli such as Staphylococcus aureus enterotoxins, and how subclones differ in their intrinsic resistance to anti-cancer drugs.

❗How can a cancer exploit its environment and still resist treatment?
✅The answer: co-existing malignant subclones.

Let me walk you through our latest study investigating how divergent evolution drives adaptability, aggressiveness, and drug resistance of T cell cancer. 1/🧵

doi.org/10.1158/2159...

Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders https://www.biorxiv.org/content/10.1101/2025.11.27.690844v1

Join us:

With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.

If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.

karriere.klinikum.uni-heidelberg.de/index.php?ac...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
www.nature.com/articles/s41...

Microglia across evolution: from conserved origins to functional divergence - Cellular & Molecular Immunology Cellular & Molecular Immunology - Microglia across evolution: from conserved origins to functional divergence

Great Review on the #evolution of #microglia

Microglia across evolution: from conserved origins to functional divergence | Cellular

www.nature.com/articles/s41...

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice @natcomms.nature.com @ryanlab.bsky.social @tcddublin.bsky.social @universitypress.cambridge.org
www.nature.com/articles/s41...

RW outcomes CD19 CAR Burkitt
- 31 pts, 3 prior LOT, most axi-cel
- 65% G3+ CRS, 19% G3+ ICANS
- 16% D+28 mortality (!!!)
- 6-mo CR 19%, mPFS 2.3 mos, mOS 6 mos
- 3 pts who got post-CAR allo all relapsed
Dismal outcomes & unmet need (BsAb? alloCAR?) #lymsm #ASH25 ashpublications.org/blood/articl...

Please share: we have an open postdoc position!🪰🪰👾We are looking for a motivated Drosophilist to join our team and explore the role of hemocytes in interorgan signaling! Interested?😎send us your application or contact me! Looking forward to hear from you!
www.uniklinik-freiburg.de/karriere/ste...

🧠 Join the next #EANO Youngsters Journal Club! Upcoming session: “Lighting up PET imaging in IDH mutant glioma” [Mair, M., Werner, J. M., Weller, J., et al. (2025), doi.org/10.1093/neuo...

🗓 November 11, 2025 | 🕓 16:30–17:30 CET
👥 Open to all EANO members | Free of charge
🔗 Learn more: www.eano.eu

Online now: A myeloid Tet2-IL-1β axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation

T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org
www.jci.org/articles/vie...

CAR19 therapy drives expansion of clonal hematopoiesis and associated cytopenias #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7746241/latest

Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures Gliomas respond poorly to therapy and are considered immunologically “cold” tumors. Cakmak et al. identify tertiary lymphoid structures (TLSs) in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment. Such TLSs may represent a key determinant of glioma immune landscape, with clinical relevance.

Online now: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures

P14.07.B CAR T-CELL THERAPY IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS: A MULTICENTER RETROSPECTIVE STUDY FROM THE LOC NETWORK AbstractBACKGROUND. The use of CAR T-cell therapy has been delayed in primary central nervous system lymphomas (PCNSL) due to the fear of unacceptable neur

CAR-T in PCNSL #lymsm
- 67 pts, 25% CSF+, 12% eye+
- 57% axicel, 30% tisacel
- 58% CR, 1-yr PFS 50%, OS 66%
- 2-yr RFS better if CR/PR at CAR infusion: 56% vs 28%
- 27% G3+ ICANS!
Almost all got bridging; would love to know which agents.
academic.oup.com/neuro-oncolo...

anti-BCMA CAR-T therapy in 5 progressive multiple sclerosis patients caused plasma cell depletion in CNS and alleviated microglial activation in cerebrospinal fluid
@cellcellpress.bsky.social www.cell.com/cell/fulltex...

👉 We are very proud to present our #EANO2025 ambassadors! Follow them on LinkedIn a/o Bluesky for a range of expert insights & join the conversation using the official hashtag #EANO2025.
We look forward to meeting you all in #Prague!

#NeuroOncology #btsm

Transcriptional regulation of disease-relevant microglial activation programs #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.10.12.681832v1

Automated classification of cellular expression in multiplexed imaging data with Nimbus - Nature Methods Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Nimbus predicts the likelihood of marker positivity from multiplexed image data in single cells.

www.nature.com/articles/s41...

Multiomics on serial glioblastoma biopsies can enable differentiation of pseudoprogression from true tumor progression
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

🚨 Call for Applications: The Hertie Network of Excellence in Clinical Neuroscience (Berlin, Bonn, Hamburg, Heidelberg/Mannheim, Munich, Tübingen) offers up to 4 postdoc/clinician scientist positions per site. Apply by Oct 31! Details 👉 www.hertie-neuroscience-hamburg.de #HertieNetwork #Jobs

Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape - Nature Neuroscience Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

www.nature.com/articles/s41...

Review @sciimmunology.bsky.social @platten-lab.bsky.social
@dkfz.bsky.social
The immunology of brain tumors
www.science.org/doi/10.1126/...

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance Recent research has revealed a remarkable role for immunosurveillance in healthy and diseased brains, dispelling the notion that this organ is a passive immune-privileged site (1–3). Better understand...

www.biorxiv.org/content/10.1...

🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights.
🔗 www.biorxiv.org/content/10.1...

Big shoutout to the whole group who made #IntegrateALL possible - especially @alinamh.bsky.social, Thomas Beder and Claudia Baldus at www.catchall-kfo5010.com