Ksenia Matlawska

Always a pleasure collaborating with the Jones Lab. Awesome science and even better people!

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.

www.nature.com/articles/s41...

Tremendous credit to first author Nitesh for his hard work, and to our funders and all our amazing collaborators who made this possible!

@nickjonesimmuno.bsky.social

Our fresh and still-steaming Journal of Clinical Investigation preprint is out! 🚀
We explore how T-cell acute lymphoblastic leukemia (T-ALL) exploits inflammatory CXCR3–CXCL10 signaling within the meninges to drive CNS infiltration.

www.jci.org/articles/vie...

Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸

Please give it a read!

www.jci.org/articles/vie...

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.

www.sciencedirect.com/science/arti...

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below!

go.bsky.app/EY3k2bE

Thank you, Dani. This is great!!!

So excited to share our work developing a new class of modular synthetic GPCRs, out today @Nature! Check it out nature.com/articles/s41...

🚨 Save the Date!🚨 ISEH is heading to Kumamoto, Japan for #ISEH2025. Check out our confirmed speakers so far and mark your calendars for a great program you won't want to miss ➡️ iseh.org/iseh2025