Carina de Oliveira Mann

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

The mechanistic basis of cargo selection during Golgi maturation Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!

@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...

Myeloperoxidase transforms chromatin into neutrophil extracellular traps @nature.com @intein.bsky.social @mpiib-berlin.mpg.de
www.nature.com/articles/s41...

Towards a molecular and structural definition of cell death Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

What is cell death?
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

📢 New preprint alert!
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...

Laser flash melting cryo-EM samples to overcome preferred orientation pubmed.ncbi.nlm.nih.gov/40877464/ #cryoEM

Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!

www.cell.com/cell/fulltex...

Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses!

#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

Excited to share our latest update on @cp-cell.bsky.social!
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

NUCLEATE Cluster of Excellence: beacon of nucleic acid research The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.

Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social

Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy.

aacrjournals.org/cancerres/ar...

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

In search of molecular switches in the immune system A decades-long search culminated in 2013 with the discovery of cGAS – a molecular switch that plays a key role in the human immune system. Carina Baer de Oliveira Mann was a doctoral student with the ...

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504

@oliveiramann.bsky.social
🎥ProLehre

Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social

Special thanks goes to our collaborators @sparrerlab.bsky.social, Andreas Pichlmair, Katja Lammens, Lars König, Dorota Kmiec, Nadine Schwierz and Min Ae Lee-Kirsch!

Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!

Check out Indra’s thread for a summary:

Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196 Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.

www.nature.com/naturecareer...

A screenshot of the results table of a Foldseek search on SubtiWiki. It shows multiple entries and corresponding metrics. One of the rows is expanded, revealing a 3D visualization of a superimposition of the target and the query structure corresponding to the search hit.

Try out our integration of the amazing protein structure search tool #Foldseek on #SubtiWiki (subtiwiki.uni-goettingen.de/foldseek)! Just upload a structure or use PDB/AlphaFoldDB entries to find similar structures. #IMPRS-GS #UniGoettingen
#alphafold #bacillus #subtilis