Ellen Hanna Singleton, PhD

The REAL AD team has arrived in Vienna for #ADPD2025 ! 🇦🇹🧠 ✨
We are excited to share our latest work and connect with fellow colleagues at the conference.
Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social

#EndAlz #Alzheimersresearch

31.03.2025 15:09 — 👍 5    🔁 2    💬 0    📌 0

Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease - Nature Medicine Plasma eMTBR-tau243 is a specific biomarker of tau tangles in Alzheimer’s disease and enables the detecting and tracking of Alzheimer’s clinical impairment.

We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ

www.nature.com/articles/s41...

31.03.2025 14:56 — 👍 47    🔁 12    💬 0    📌 1

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...

led by Michael Heneka, published in @natrevimmunol.bsky.social today

(MANY more authors listed and linked below)

10.12.2024 03:03 — 👍 144    🔁 51    💬 1    📌 4

@zimmerneurolab.bsky.social debut here in 🦋 with an autoradiographic head-to-head study comparing tau PET tracers in the postmortem brain tissue 👇

25.11.2024 18:34 — 👍 8    🔁 2    💬 1    📌 0

Congrats Eduardo et al!! 👏

26.11.2024 10:41 — 👍 1    🔁 0    💬 1    📌 0

Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...

25.11.2024 17:59 — 👍 29    🔁 10    💬 1    📌 2