Alessandra Magistrato

Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides Microbial effectors Nep1-like proteins bind to different plant sphingolipids and disrupt di- and monocot model lipid membranes.

Our new work entitled 'Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides' has been published on Science Advances!
In collaboration with Gregor Anderlu, NIC, Slo read 👇 www.science.org/doi/10.1126/...

17.10.2025 08:49 — 👍 5    🔁 1    💬 0    📌 0

Decoding Spliceosome Dynamics through Computation and Experiment RNA splicing is orchestrated by a complex and exceptionally dynamic RNA–protein machine, called the spliceosome. Stepwise, large-scale structural and compositional remodeling of the spliceosome enable...

Our new review entitled 'Decoding Spliceosome Dynamics through Computation and Experiment' has been published on Chemical Reviews @pubs.acs.org Congrats to @pokorna.bsky.social, Sebastian Fica and Jana Aupic! pubs.acs.org/doi/10.1021/...

14.10.2025 08:51 — 👍 9    🔁 4    💬 0    📌 0

Almost at the end of the exciting @cecamevents.bsky.social conference 'RNA Modelling across scales' at SISSA, Trieste, Italy! 🎉 Fantastic speakers and great science. Organized with @bussigio.bsky.social @marcodevivo.bsky.social #RNA

21.05.2025 19:22 — 👍 19    🔁 8    💬 0    📌 3

Our integrative approach using #MD and #cryoEM data to construct structural ensembles of #RNA just published on @natcomms.bsky.social doi.org/10.1038/s414... Lead by Elisa Posani, with @magistratolab.bsky.social @bonomimax.bsky.social @pjanos.bsky.social @navtejtoor.bsky.social and Daniel Haack 🎉

16.05.2025 09:16 — 👍 26    🔁 8    💬 0    📌 0

Check out the speakers!
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky

09.05.2025 10:37 — 👍 9    🔁 5    💬 0    📌 0

Identification of a new Small Rho GTPase Inhibitor Effective in Glioblastoma Human Cells Glioblastoma (GBM) is the most common and lethal primary brain tumour. The prognosis for GBM patients remains poor due to rapid tumour recurrence and …

Just published our new paper on Identification of a new Small Rho GTPase Inhibitor Effective in Glioblastoma Human Cells. Check it out! www.sciencedirect.com/science/arti.... Excellent work done by
@angelaparis3.bsky.social , in collaboration with University of Trieste, University of Udine, CNR-IC

05.05.2025 11:54 — 👍 7    🔁 2    💬 0    📌 0

📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods.bsky.social

📖 Read it here: rdcu.be/ef6YX

📝 Support the statement: bit.ly/3zVS3qm

#MDDB #FAIRdata #collaboration

04.04.2025 08:09 — 👍 37    🔁 21    💬 0    📌 3

We are sill accepting applications for poster presentations at the CECAM conference 'RNA Modelling Across Scales". Join us in the beautiful Trieste ☀️🏖️🏰! Apply now: www.cecam.org/workshop-det... Co-organized with @bussigio.bsky.social @marcodevivo.bsky.social

27.03.2025 19:04 — 👍 10    🔁 5    💬 0    📌 0

All-Atom Simulations Elucidate the Molecular Mechanism Underlying RNA–Membrane Interactions RNA–membrane interactions are starting to emerge as an important organizing force in both natural and synthetic biological systems. Notably, RNA molecules were recently discovered to be present on the...

Interested in understanding the molecular details of RNA–membrane association? Read our new paper just published in Nano Letters @acs.org. Excellent work done by sdimarco.bsky.social with Jana Aupic and @bussigio.bsky.social pubs.acs.org/doi/full/10....
#RNA #MembraneBiology #compchem #compbiol

09.03.2025 11:39 — 👍 9    🔁 3    💬 0    📌 0

CECAM - RNA modelling across scales

Interested in #RNA modelling across multiple scales? Join us for the @cecamevents.bsky.social meeting at SISSA, Trieste, May 19-22! www.cecam.org/workshop-det... We still have slots for contributed talks. Deadline March 23. Co-organized with @magistratolab.bsky.social and @marcodevivo.bsky.social

20.02.2025 19:22 — 👍 18    🔁 11    💬 0    📌 1

News - EuChemS WINNER ANNOUNCEMENT! “EuChemS ChemBioLife Young Investigator Award” 2024-2025 edition   We are proud to announce the winner of the EuChemS ChemBioLife Young Investigator Award  of the EuChemS Division...

Very proud to announce that a member of our group, Dr. Jana Aupič, has been awarded the prestigious "EuChemS ChemBioLife Young Investigator" prize! 🏅 This honors her hard work and exceptional contribution to chemical biology. Congratulations, Jana! 🌟✨ .
www.euchems.eu/divisions/ch...

04.02.2025 16:03 — 👍 10    🔁 5    💬 0    📌 0

Two PhD vivas just before the end of the year! Bea and Irene defended their theses in front of two committees of leading female researchers: @magistratolab.bsky.social, Laura Masgrau, Montse Terrazas, @elisafadda.bsky.social, Salomé Llabrés and Mercedes Alfonso-Prieto. Congrats to Irene and Bea!

23.12.2024 09:40 — 👍 11    🔁 2    💬 0    📌 0

✨Great presentation of our work by @angelaparis3.bsky.social at Physics Day in Trieste!👏

13.12.2024 15:17 — 👍 6    🔁 1    💬 0    📌 0

Assessing the Mechanism of Rac1b: An All-Atom Simulation Study of the Alternative Spliced Variant of Rac1 Small Rho GTPase The Rho GTPase family plays a key role in cell migration, cytoskeletal dynamics, and intracellular signaling. Rac1 and its splice variant Rac1b, characterized by the insertion of an Extraloop, are fre...

Just published in Journal of Chemical Information and Modeling our new study on the Mechanism of Rac1b: the Alternative Spliced Variant of Rac1 Small Rho GTPase. Great work by A. Parise and S. Cresca!
pubs.acs.org/doi/10.1021/...

09.12.2024 15:33 — 👍 15    🔁 6    💬 0    📌 0