Yu-Chiun Wang

We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social

Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...

Please re-post 🙏

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study!

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

Lab Meeting with the Phng Lab - the Node Meet the Phng Lab, based at the RIKEN Center for Biosystems Dynamics Research, Japan. The lab is interested in vascular morphogenesis and, in particular, endothelial cell mechanobiology.

Lab Meeting with the Phng Lab

Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟

Find out more about the lab and what it's like working at RIKEN BDR:

Gastruloids employ an alternative morphogenetic route to generate a posterior body axis on adherent substrates Morphogenesis emerges from the integration of genetic programs with environmental signals, yet studying this interplay in embryos remains challenging due to the inherent complexity of embryonic system...

shorturl.at/v01DO

Out now! Our very first paper@crick.ac.uk, an impressive feat by @tobyandrews.bsky.social where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️
www.cell.com/developmenta...

Cytoplasmic localization of the mRNA encoding actin regulator, Serendipity-α, promotes adherens junction assembly and nuclear repositioning
#Drosophila

Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)

Stretching the immortal Hydra Dresden researchers show how cells can create a new organism from scratch by coordinating their mechanical properties.

Stretching the immortal Hydra. Publication by @paveltomancak.bsky.social group with Carl Modes @mpi-cbg.de & @zechnerlab.bsky.social shows how cells can create a new organism from scratch by coordinating their mechanical properties. @anaisbailles.bsky.social @pnas.org www.mpi-cbg.de/news-outreac...

Excited to share a new preprint from the lab!

This (doi.org/10.1101/2025...) and an earlier one (doi.org/10.1101/2025...) mark my lab's first steps into studying how Polycomb modifications get established in early Drosophila development.
🧵 1/10

Brillouin microscopy showing strength in non-invasive, live-imaging applications!

Studying fruit fly embryos during gastrulation as cells rapidly change shape @prevedel-lab.bsky.social @gomezjm-devmech.bsky.social @marialep.bsky.social characterised & mapped mechanical changes in 3D. rdcu.be/ev6ZX

Japan requires name change after marriage — with big effects on female scientists Nature - Survey finds law requiring married couples to share the same family name causes havoc for researchers.

Japan is the only country in the world that legally requires married couples to share the same family name

https://go.nature.com/4lfbXPL

Integrins coordinate basal surface contraction and oriented cell growth to enable thickening of a curved epithelium During development, tissues undergo morphogenesis to achieve their final form. This process relies on coordinated cell shape changes, which have predo…

Delighted to share our latest work on the mechanisms of epithelial curvature and 3D morphogenesis ! Amazing work from newly graduated Dr @courtneyl7a7.bsky.social 🎉

@lmcb-ucl.bsky.social
@uclnews.bsky.social
@ucllifesciences.bsky.social

www.sciencedirect.com/science/arti...

Rapid transcriptional response to a dynamic morphogen by time integration During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

New work on dynamics of morphogen signaling:

Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input

Morphogen signalling dynamics + GRN for tissue patterning

www.biorxiv.org/content/10.1...

Chordin-mediated BMP shuttling patterns the secondary body axis in a cnidarian Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.

David’s @davidmoersdorf.bsky.social cool paper about the role of Chordin in BMP signaling in the sea anemone Nematostella is finally out www.science.org/doi/10.1126/...

Such an exhilarating meeting —thanks to all those who travel the distance, the ECRs, the staff and none other than Fumio Motegi. A personal heartfelt note to all who helped me overcome my disability, which explains my absence in the group photo!

Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi

@ipparis.bsky.social @polytechniqueparis.bsky.social

🧵 1/6
Just dropped in @naturecomms.bsky.social

We’ve engineered the most photostable yellow fluorescent proteins (YFPs) to date—mGold2s and mGold2t—with up to 25× greater photostability than mVenus and mCitrine, without compromising brightness.

👇
🔗 www.nature.com/articles/s41...

A) Diagram of the RUSH system. The Halo-tagged cargo is retained in the ER by the binding of the Streptavidin binding peptide (SBP) to Streptavidin (StrepA), which is fused to the ER retention signal, KDEL. The cargo is synchronously released upon the addition of biotin, which outcompetes SBP for binding to Streptavidin.B) Diagram of the tagged cargo constructs used in this study. C) Steady state expression of UAS-SBP-Halo-Cadherin99c (magenta) under the control of traffic jam-Gal4, showing its localization to the apical microvilli. Phalloidin staining of F-actin (green) labels the apical microvilli in the follicle cells and the oocyte. Scale bar 10 µm. D) Steady state expression of UAS-SBP-SNAP-Ndg (magenta) under the control of traffic jam-Gal4, showing its localization to the basement membrane. Actin is shown in green. Scale bar 10 µm. E) En face view of SBP-SNAP-Ndg in the basement membrane. Scale bar 10 µm. F) Time course of SBP-Halo-Cadherin99C trafficking in fixed samples. G) 25 min after release from the ER, Cad99c (green) localizes to subapical puncta that are labeled by Rab11 (magenta). Scale bar 10 µm. In all figures with a cross-section of the follicle cells, apical is toward the top of the image and basal toward the bottom.

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp

Our colleague Prof. Benny (Ben Zion) Shilo passed away this morning @WeizmannScience . Benny worked at the forefront of world science in the study of molecular and developmental genetics. Among other things, he won the A.M.T. Prize in the field of genetics in 2013. He was also a great explainer of science, a kind teacher - and an artist photographer with a sharp eye and a sensitive soul. Benny, we will miss you very much. May his memory be blessed.

Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪

Mark your calendars for another VGZT Eastern session ☀️☕

🗓️ Wednesday Apr 09
⏰ 17:00 JST / 8:00 UTC / 10:00 CET

Bipasha Dey
“Divergent evolutionary strategies prevent tissue collision in fly embryos”🪰

Chii Jou (Joe) Chan
“Ovarian mechanobiology: roles of compressive stress in follicle development”🐁

Adhesion-driven tissue rigidification triggers epithelial cell polarity The active regulation of tissue material properties via phase transitions is central in morphogenesis. Transitions abruptly occur at critical points in diverse control parameters, including cell densi...

🔗 You can read the full story here:
www.biorxiv.org/content/10.1...
#DevBio #Mechanobiology #Biophysics

It takes 2 to PCP (or 3 to align with global cues)! Congrats @eposfai.bsky.social and Danelle!

When it comes to discovery, we need to remember that our instincts often create an illusion that misleads us into believing that we understand something completely, even though there are many things about it that we don’t and we need to figure out how to ask the right questions!

In a country not known for English-based education, we (tinyurl.com/yc7t8jjw) actually have some excellent labs that are international and English-proficient (including us! tinyurl.com/mr482jzh). Find a good match and get in touch! Science is well and alive here.

Tremendous job @sameerthukral.bsky.social for pulling the impossible off and proving the doubters wrong. Perfect reminder of why we are here in the first place: to bring in things people here don’t know exist and to show them how much fun science can be and has been for me.

Such exhilarating 2day extravaganza of day+night science=fun+paradigm shifting science: lost art no more! Thanks a million @itaiyanai.bsky.social for the energy/enthusiasm brought to our ECRs. Learned so much. Let the conversations continue!

What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...

Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!