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NAADP-mediated calcium release promotes angiopoietin 2 secretion by regulating Rab46-dependent Weibel-Palade body trafficking Angiopoietin2 (Ang2), a regulator of angiogenesis, is stored with other pro-inflammatory and pro-thrombotic mediators, in endothelial-specific vesicle…

Congrats to Prof Lynn McKeown's group at @universityofleeds.bsky.social for sciencedirect.com/science/article/pii/S0143416025000776, showing that histamine induces local Ca²⁺ release, leading to Ang2 secretion from endothelial cells. Proud our a-Rab46 antibody and Ang2 ELISA kit helped discovery!

Shout out to @cambiochem.bsky.social at @cam.ac.uk! We had a wonderful time meeting you all and hearing about your exciting research! Want more details on our products? or maybe you want our team to visit your department? get in touch here or email us at info@antibodies.com!

Congrats @rafsarnataro.bsky.social, the winner of our quarterly travel grant, who is currently at #SfN25. We are both excited and proud to support this cool research on the mitochondrial origins of the pressure to sleep! Shout out to @sfn.org!

Really excited to see you soon, @cambiochem.bsky.social !

We are so excited to see you soon! Make sure you stop by!

Did you know we offer special Elisa kits? No time? No problem! check out our 90-minute Elisa kits tinyurl.com/90minuteelisa! tiny mouse samples? Don't worry: Our small-volume Elisa kits are optimized for 25 ul so you can make the most of every microliter tinyurl.com/SmallVolumeE...!

Looking forward to seeing you, @cambiochem.bsky.social !

Our team will be at the Biochemistry Department (Sanger Building) at the University of Cambridge on Tuesday, November 18th. Be sure to drop by for a conversation. Interested in a one-on-one meeting? Reach out to us, and we’ll arrange a session for you!

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HDAC6-dependent deacetylation of SAE2 enhances SUMO1 conjugation for mitotic integrity | The EMBO Journal imageimageThe basis and significance of SUMO1 vs SUMO2/3 conjugation preference remains incompletely understood. Here, deacetylation of SAE2, the SUMO-activating E1 enzyme, during mitosis is found to…

SUMO proteins are important in intracellular processes. New research identifies that deacetylation of the SUMO-activating enzyme during mitosis can promote proper chromosome segregation.

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Expression of HCMV-Encoded miRNA in Subjects Acutely Coinfected with HIV: Correlation with Inflammation and Immune Activation Human cytomegalovirus (HCMV) coinfection is associated with a faster HIV disease progression and adverse clinical outcomes. HCMV-encoded miRNA expression, in individuals acutely infected with HIV…

Study shows that HCMV miRNA profiles differ in HIV coinfection, linking specific miRNAs to viral load and inflammation. Here, they identify as key markers in HIV/HCMV pathogenesis.

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Synovial fluid extracellular vesicles from osteoarthritis patients drive cartilage breakdown & pain. Potential new targets to slow OA progression.

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Chondrocytes have been shown to engage with CD4+ T cell subsets in osteoarthritis, suggesting potential for T cell-focused therapies to influence inflammation in OA joints

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Single-nucleus atlas of human fat tissue can be used to understand adipose tissue dysfunction. Weight loss can have significant effects on cellular process that are linked to metabolic health. (#A270328, THPTA Ligand) www.nature.com/articles/s41...

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