@KingOfPathogens

📣 EJI is proud to share that this year’s Nobel Prize winner, Shimon Sakaguchi, published with us on 6 October: bit.ly/46R7n4g
We extend our heartfelt congratulations to Shimon for receiving the prize in recognition of his pioneering work on Tregs. #NobelPrize #Immunology #Tregs

a cartoon of homer simpson and bart simpson sitting on a couch with the words welcome join the club ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words welcome join the club

Welcome back - I’ve had no one to troll about TB!

Asked lots about this piece on Chronic Lyme disease, and disappointed in the @guardian (a publication I both subscribe and contribute to) for running it. Short thread explaining the multitude of problems with it, and why I consider it irresponsible to run as is..🧵

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

Denise Kirschner talks about her research for Discovery Research week storage.thankview.com/uploads-vide...

Congrats - it’s all gravy from here on!!!!

I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com

Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain. Credit: Rioka Hayama

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP

Ian Banks - The Wasp Factory! One critic described it as "a work of unparalleled depravity"

Hearing from someone in NIH program:

“Our final Task Order for $6.2M went out today. Every obstacle DOGE put up to keep us from funding new TOs and extending others was overcome. My fired contract officers were rehired. It was a lot of work, but we did it.
For now.”

Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with...

I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...

Toxoplasma for the win! There is a reason its the King of Pathogens!

'South Park' Gives FCC's Brendan Carr Explosive Diarrhea and Nearly Takes Away His 'Freedom of Speech' amid Kimmel Controversy 'South Park' aired its first episode since Jimmy Kimmel's late-night show was pulled by ABC. The episode comes after series creators Trey Parker and Matt Stone announced there would be no new episode ...

people.com/south-park-r.... Toxoplasma for the win!!

Hello @notredame.bsky.social ! Looking forward to my lecture tomorrow. Details here: science.nd.edu/events/2025/...

Hello everyone! I am a postdoc in mucosal immunology and I am looking for new postdoc position in Europe! I know a lot about gut mast cells, but also CD4 T cells and type 2/3 immunity in general. I've worked with single cell sequencing and neuroimmune interactions. Feel free to share! Thank you! ♥️🥼👩‍🔬

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

RFK Jr critic Paul Offit removed from FDA vaccine advisory committee. Paul remains one of the most thoughtful scientists I know to articulate the importance of vaccine safety and proper clinical trials!

In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...

Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

It's #MucosalMonday! Catch the latest Mucosal Immunology podcast, "Timing Exposure to Microbes," featuring Dr. Michael Silverman, from Children's Hospital of Philadelphia - brought to you by SMI and the Mucosal Immunology Journal. Listen here -> bit.ly/4lxNC7F

CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.

#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...

What to Know About Plague After a New Case in California

Yes plague still exists in many parts of the world including the western US:

What to Know About Plague After a New Case in California www.nytimes.com/2025/08/22/h...

"If Joe Biden federalizes the National Guard, that would be a direct attack on states' rights." - Kristi Noem, Feb 6, 2024

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

Experts condemn NIH director’s defense of cut to vaccine research

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social
www.nature.com/articles/s41...

Looks like one of our ‘imprinting’ papers was cited in the HHS data package, despite our conclusion that people receiving an ancestral mRNA vaccine were better at producing antibodies against variants compared to unvaccinated people.