Cardiovascular Diseases Research Institute

A Tick of the Clock: Finding the Sweet Spot in Tilt Table Test. The Effectiveness of Short‐Duration Head‐Up Tilt Test as a Diagnostic Tool in Suspected Vasovagal Patients: A Retrospective Observationa... In patients with suspected vasovagal syncope, a 15-min head-up tilt test protocol yielded similar diagnostic results to the conventional 20-min protocol. This shorter approach may improve patient com....

Is 15 minutes enough? Our retrospective study of 724 patients shows that the 15‑min head-up tilt test yields results similar to the 20‑min protocol and could improve efficiency and patient comfort. #Syncope #Tilt #Cardiology onlinelibrary.wiley.com/doi/10.1002/...

An Unusual Presentation of Metastatic Soft Tissue Sarcoma to the Left Atrium and Pulmonary Veins: A Case Report and Comprehensive Literature Review A summary of the patient's history and treatment process.

Rare case of metastatic soft tissue #sarcoma invading the left atrium and pulmonary veins—an exceptional cardiac spread reviewed in detail. #CardioOncology #CaseReport #Oncology onlinelibrary.wiley.com/doi/10.1002/...

Efficacy and safety of colchicine in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials - BMC Cardiovascular Disorders Background The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inc...

#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....

Journal of Diabetes & Metabolic Disorders

New study in 'Journal of Diabetes & Metabolic Disorders' reveals high prevalence of metabolic syndrome in Tehran adults. Key risk factors: age, gender, education, and physical activity. 🛟 bit.ly/4gyo5Kf

Tricuspid Valve Replacement Using the Right Atrial Appendage Valve: Techniques and 1-Year Results Tricuspid regurgitation (TR) is a significant valve disorder with limited data on management outcomes.

Using the patient’s own right atrial appendage for #tricuspid valve replacement showed perfect 1‑year results—no mortality or regurgitation in 6 cases. A promising step for complex valve repair! #HeartSurgery academic.oup.com/icvts/articl...

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Lower estimated glucose disposal rate (eGDR), a marker of #InsulinResistance, strongly predicts major adverse cardio-cerebrovascular events in both diabetic and non-diabetic populations. #MetaAnalysis journals.sagepub.com/doi/10.1177/...

A rare case links Scimitar syndrome with #VaginalAgenesis and a history of imperforate anus — findings that hint at a #VACTERL spectrum association. Highlights the complex interplay of congenital anomalies across organ systems. crcp.tums.ac.ir/index.php/cr...

EXPRESS: Dehydrocorydaline can be a suitable candidate for analgesic purposes: a review on the current preclinical evidence - Mehdi Dehghani, Behrang Nooralishahi, Fatemeh Rezaee Tazangi, 2025 Pain stands as one of the main factors related to human disability and suffering, with different classifications (e.g., acute/chronic, somatic/visceral, and mal...

#Dehydrocorydaline, an #alkaloid from Rhizoma Corydalis, shows strong preclinical potential as a natural #pain reliever with anti-inflammatory and neuroprotective effects. #Analgesia journals.sagepub.com/doi/10.1177/...

Carbohydrate antigen 125 and clinical outcomes in heart failure: systematic review and meta-analysis - BMC Cardiovascular Disorders Introduction Carbohydrate Antigen 125 (CA125) has emerged as a potential biomarker in patients with heart failure (HF). This meta-analysis comprehensively evaluates the association between CA125 levels and clinical outcomes across HF populations. Methods We conducted this study based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). We systematically searched PubMed, Scopus, Web of Science, and Embase libraries up to April 2025. We selected the original English-language investigations that reported the association between CA125 levels and clinical outcomes in cases with HF. The random-effects model and Hartung-Knapp-Sidik-Jonkman method were used to pool effect sizes and report summary statistics. The current review was registered in PROSPERO (CRD420251023141). Results A total of 20,458 cases were included from 29 studies, with an average age of 70.3 years, and 36.1% of cases were women. The average cut-off level was 37.78 U/mL, and 35 U/mL was mainly used as the CA125 cut-off level. A meta-analysis of nine studies that reported the risk of experiencing endpoint events (death or HF-related hospitalization) showed significantly higher risk (HR 2.23, 95% CI 1.69–2.93; p < 0.01; I2 = 75.0%) among the patients with higher CA125 levels compared to those with lower levels. The increased risk remained significant across the acute heart failure (AHF) (HR based on two studies: 1.88, 95% CI 1.54–2.30; p < 0.01; I2 = 39.6%) and chronic heart failure (CHF) (HR based on seven studies: 2.52, 95% CI 1.69–3.77; p < 0.01; I2 = 77.4%) subgroups. Furthermore, a correlation meta-analysis of 13 studies revealed a significant direct correlation between CA125 and pro-BNP levels (r = 0.42; 95% CI 0.30 to 0.54; p < 0.01; I2 = 96.9%). Conclusion The current review findings revealed CA125 as a significant prognostic factor of mortality and hospitalization risks in HF population. Furthermore, CA125 could be a non-invasive and operator-independent tool for evaluating disease severity and monitoring response to therapy. We suggested CA125 for monitoring various treatments in individuals with HF, specifically diuretic therapy. Further prospective studies are needed to determine the optimal cut-off for CA125 levels in HF.

Carbohydrate Antigen 125 is a strong predictor of death and hospitalization in #HeartFailure patients. It correlates with disease severity and helps guide treatment. #CA125 #Biomarkers bmccardiovascdisord.biomedcentral.com/articles/10....

The role of glucagon-like peptide-1 receptor agonists in weight regain treatment or prevention after bariatric surgery: a systematic review and meta-analysis - Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Background Weight regain (WR) and insufficient weight loss (WL) occur in 20–25% of patients after bariatric surgery due to various factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promise in promoting WL; however, evidence regarding their effectiveness in managing WL and preventing WR post-bariatric surgery remains limited. Objective This study aims to evaluate the role of GLP-1RAs in treating and preventing WR following bariatric surgery. Methods A systematic search was conducted across PubMed, Scopus, and Web of Science for studies assessing the impact of GLP-1RAs on WR after bariatric surgery. Results Our search identified 27 original studies, with 10 included in the meta-analysis involving 769 participants (392 treated with GLP-1RAs). The mean age was 44.05 years, with 30.47% male. The time interval from surgery to the initiation of GLP-1RAs treatment ranged from 1.5 to 86.7 months, with treatment durations between 4 and 12 months. The analysis showed significantly greater WL in the GLP-1RAs group compared to placebo (SMD = 0.82, 95% CI 0.23 to 1.42). Subgroup analysis for treatment durations ≤ 6 months indicated a higher WL in the GLP-1RAs group (SMD = 0.79, 95% CI 0.25 to 1.34). Adverse events were primarily gastrointestinal, with nausea significantly more frequently in the GLP-1RAs group (OR = 2.01, 95% CI 1.24 to 3.27). Conclusion GLP-1RAs effectively promote WL among participants experiencing WR after bariatric surgery. Initiating GLP-1RAs therapy shortly after surgery may help prevent WR. Further research is warranted to explore long-term outcomes and optimize treatment protocols for this patient population. Graphical Abstract

GLP-1 receptor agonists (GLP-1RAs) boost weight loss and help fight #WeightRegain after #BariatricSurgery, according to the latest #MetaAnalysis. Early treatment shows greater effects. Most side effects are mild and gastrointestinal. More long-term data needed! link.springer.com/article/10.1...

Analgesia and silymarin: What are the opportunities and challenges? - Mehdi Dehghani Firoozabadi, Behrang Nooralishahi, Fatemeh Rezaei-Tazangi, 2025 Pain is an unpleasant sensory and emotional sensation about actual or possible tissue damage that can cause remarkable health and economic problems. For pain re...

#Silymarin, a natural flavonoid from milk thistle, shows promise as a safer alternative for pain relief, especially in inflammatory and neuropathic conditions. Its potential synergy with other drugs offers new opportunities in analgesic therapy. #analgesia journals.sagepub.com/doi/10.1177/...

EXPRESS: Honokiol and analgesia: a mechanistic review on the current capacities and challenges - Behrang Nooralishahi, Mehdi Dehghani, Fatemeh Rezaee Tazangi, 2025 Pain is an unfavorable subjective sensation influencing 20% of the public population, giving rise to substantial health and economic issues. Several categories ...

#Honokiol: more than a polyphenol. This mechanistic review highlights its promising analgesic effects in inflammatory, neuropathic, and gouty #pain, alongside anti-cancer, anti-inflammatory, and antioxidant benefits. #Analgesia #Antinociceptive journals.sagepub.com/doi/10.1177/...

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Emerging lipid biomarkers Visceral Adiposity Index, Lipid Accumulation Product, and Atherogenic Index of Plasma show promise in predicting diabetic kidney disease but not diabetic retinopathy. #DiabetesMellitus journals.sagepub.com/doi/10.1177/...

Association Between Clonal Hematopoiesis of Indeterminate Potential and Risk of Venous Thromboembolism: A Systematic Review and Meta‐Analysis Objectives Clonal hematopoiesis of indeterminate potential (CHIP), marked by age-related somatic mutations in hematopoietic cells, has been linked to cardiovascular disease. Given its shared risk pr...

Clonal hematopoiesis of indeterminate potential is associated with a 1.5-fold higher risk of #VenousThromboembolism, indicating a potential new risk factor. #MetaAnalysis onlinelibrary.wiley.com/doi/10.1111/...

QRS notching does not predict response to #CardiacResynchronizationTherapy in heart failure patients with left bundle branch block. CRT is beneficial regardless of QRS morphology. #Myocardium #VentricularDysfunction brieflands.com/articles/jjc...

Estimated glucose disposal rate and risk of cardiovascular events in type 1 diabetes: a systematic review and meta-analysis - Diabetology & Metabolic Syndrome Background Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in individuals with type 1 diabetes mellitus (T1DM), with insulin resistance (IR) increasingly recognized as a key contributor. The estimated glucose disposal rate (eGDR), a surrogate marker of insulin sensitivity, has been proposed as a predictor of adverse cardiovascular outcomes in T1DM. This systematic review and meta-analysis aimed to assess the association between eGDR and adverse cardiovascular outcomes. Methods A systematic search of PubMed, Embase, Scopus, and Cochrane Library was conducted through March 6, 2025, to identify studies reporting multivariable-adjusted risk estimates linking eGDR with cardiovascular outcomes in individuals with T1DM. Pooled hazard ratios (HRs) were estimated using random-effects models with the Paule–Mandel method and Knapp–Hartung adjustment. Subgroup and meta-regression analyses were conducted to explore potential effect modifiers, and leave-one-out (LOO) sensitivity analyses were performed to assess the robustness of findings. Results Sixteen studies comprising 29,075 individuals with T1DM were included. Higher eGDR was significantly associated with lower risk of MACE and all-cause mortality, with hazard ratios per unit increase of 0.79 (95% CI: 0.72–0.87; I² = 63%) and 0.84 (95% CI: 0.82–0.86; I² = 0%), respectively. Lower eGDR was also associated with increased risk of CAD (low vs. high eGDR: HR 3.61; 95% CI: 2.83–4.62; I² = 0%). Subgroup analyses suggested a stronger protective association between eGDR and MACE among older individuals (≥ 40 years), those with BMI < 25 kg/m², and those with longer diabetes duration (≥ 20 years). LOO sensitivity analyses showed that CAD was the only outcome influenced by exclusion of the largest study. Conclusions Lower eGDR is consistently associated with increased risk of MACE, CAD, and all-cause mortality in individuals with T1DM. These findings support the utility of eGDR as a practical, non-invasive marker for cardiovascular risk stratification in this high-risk population. Graphical Abstract

Lower #EstimatedGlucoseDisposalRate (eGDR), a marker of insulin resistance, predicts higher risk of cardiovascular events and mortality in type 1 diabetes. eGDR is a simple, effective tool for cardiovascular risk stratification in this population. dmsjournal.biomedcentral.com/articles/10....

#Bodybuilders show strong #nutrition #knowledge, but key gaps remain around alcohol and supplement use. Findings highlight a need for focused nutrition education for athletes. #Socio-demographic #Attitudes #Anthropometric bmcsportsscimedrehabil.biomedcentral.com/articles/10....

Successful management of a delayed-presented and complicated right ventricular pseudoaneurysm: a case report and literature review - Journal of Cardiothoracic Surgery Introduction Right ventricle (RV) pseudoaneurysm is a substantially rare but fatal condition that should be diagnosed promptly to prevent severe complications, such as rupture and death. However, due to its nonspecific presentation, its diagnosis relies mainly on advanced imaging cardiac modalities. This report describes the successful management of a delayed and unusual presentation of RV pseudoaneurysm. Case presentation A 31-year-old white male patient with a history of pericardiectomy presented with chest pain and dyspnea, which worsened by exertion, and edema of the lower extremities, which had started several weeks ago and had been exacerbated over time. The initial evaluations with cardiac enzyme check, chest X-ray, and electrocardiogram were unremarkable, and the patient was planned to undergo a transthoracic echocardiogram (TTE). TTE revealed RV failure and increased RV diameter; a suspicious lesion in the RV apex was also detected, suggesting a pseudoaneurysm. Cardiac Computed Tomography (CTA) confirmed the diagnosis, and interventional treatment via an Amplatzer device was considered, which was rejected by the interventional cardiologist of the center due to the lack of experience and logistics for such intervention. Considering the patient’s condition deterioration, the patient was transferred to an operating room, and an open-heart surgery was performed to suture the ruptured RV myocardium. The pericardial effusion was removed. The histopathological evaluation of the sample confirmed the diagnosis. The post-surgical recovery and follow-up were uneventful. The graphical abstract is added below to illustrate the case and summarize it. Conclusion (Clinical key point) Right ventricle pseudoaneurysms can present with unusual symptoms and signs, and misdiagnosis is highly probable. Advanced imaging techniques after the initial echocardiogram might be necessary to confirm the diagnosis. Moreover, timely, appropriate, and wisely chosen treatment (interventional or surgical) can result in uneventful treatment and recovery. Graphical abstract

A rare cardiac challenge unveiled: delayed-presenting right Ventricular #pseudoaneurysm in a 31-year-old male. Multimodality imaging enabled diagnosis, and timely surgical repair ensured full recovery. #Echocardiography #CardiacImaging cardiothoracicsurgery.biomedcentral.com/articles/10....

#Octreotide reduces the risk of overall and moderate post-ERCP #pancreatitis, offering a promising preventive approach. More research is needed to confirm its role in mild and severe cases. #prophylaxis #MetaAnalysis journals.lww.com/jcge/abstrac...

Intensive #BloodPressure control in #Type2Diabetes shows clear benefits: lower risk of #MACE, stroke, and MI without added diabetes-related complications. Findings from 21 studies, >290k participants, support stricter BP targets in T2DM. #MetaAnalysis#hypertension academic.oup.com/ajh/advance-...

Enhanced Alginate Microparticles Fabricated by a Microfluidic System for Local Mesalamine Delivery to Inflammatory Bowel Disease Mesalamine (Mes) is a first-line anti-inflammatory agent extensively used to treat inflammatory bowel disease (IBD). Mes can be locally delivered using alginate-based microparticles as a pH-sensitive ...

New microfluidic-made alginate–κ-carrageenan microparticles show controlled, pH-sensitive mesalamine delivery with improved stability and reduced inflammation markers in #IBD models. #Biomaterials #Microfluidics pubs.acs.org/doi/10.1021/...

#FamilialHypercholesterolemia raises mortality risk in #PrematureCoronaryArteryDisease patients, despite similar #MACCE rates. Large-scale cohort study highlights critical need for targeted intervention. jthc.tums.ac.ir/index.php/jt...

Novel inflammatory markers based on complete blood count and PBMV success in rheumatic mitral stenosis Inflammatory markers are associated with the severity of disease and outcomes in rheumatic mitral stenosis (RMS). This study explored the connection between newer inflammatory indices – specificall...

Systemic #InflammationMarkers, especially the systemic inflammation response index, predict success of percutaneous balloon mitral valvuloplasty in rheumatic mitral stenosis with high accuracy. This aids clinical decision-making. www.tandfonline.com/doi/10.1080/...

#Smoking history shapes hematologic profiles. In the #BandarKongCohort, latent class analysis of CBC indices revealed strong links between current smoking and both #beta-thalassemia minor and mixed #anemia. www.nature.com/articles/s41...

Biventricular Thrombi in a Patient With Dilated Cardiomyopathy In patients with dilated cardiomyopathy, it is important to thoroughly examine the right ventricle for the presence of a thrombus during transthoracic echocardiography, in addition to the left ventri....

Biventricular thrombi can complicate #DilatedCardiomyopathy. Careful #RightVentricular assessment on #echocardiography is essential when #LeftVentricular #thrombus is detected. onlinelibrary.wiley.com/doi/10.1002/...

Central Illustration: Overview of the trial

Iranian multicentre trial

Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope: A Randomized Sham-Controlled Trial

www.jacc.org/doi/10.1016/...

"The results do not support routine use of thigh-length ECS [elastic compression stockings]"

#VVS #OrthostaticIntolerance #OI

Intensive versus Less-Intensive Blood Pressure Control in Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Clinical Trials Abstract. Introduction: High blood pressure accelerates chronic kidney disease (CKD) progression, but the optimal intensity of blood pressure control in this population remains unclear. We aimed to de...

#MetaAnalysis of 11 RCTs (n=8,740) shows intensive #BloodPressure control offers no significant benefit over standard targets in #ChronicKidneyDisease patients for mortality, CV events, or renal outcomes. #Hypertension karger.com/ajn/article-...

(PDF) An Anomalous Right Coronary Artery Originating from the Left Anterior Descending Artery, a Case Report of Successful Percutaneous Coronary Intervention PDF | Background: An anomalous right coronary artery (RCA) originating from the left anterior descending artery (LAD) is a rare subtype of single... | Find, read and cite all the research you need on ...

Rare case of an anomalous right coronary artery from the LAD successfully treated with #PCI in a 57‑year‑old woman, underscoring the need for awareness and screening. #Cardiology #CoronaryAnomaly www.researchgate.net/publication/...

Early initiation of SGLT2 inhibitors in acute myocardial infarction and cardiovascular outcomes, an updated systematic review and meta-analysis - BMC Cardiovascular Disorders Background Sodium-glucose cotransporter-2 (SGLT2) inhibitors increase survival rate in heart failure, but early initiation of these agents after acute myocardial infarction (MI) is controversial. Meth...

Early initiation of #SGLT2 inhibitors after acute #MI may lower risk of #HeartFailure hospitalization and MACE, though mortality benefits remain uncertain. Evidence from 10 studies (15k+ pts) underscores their growing role in #Cardiology. bmccardiovascdisord.biomedcentral.com/articles/10....

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The Trends in the Prevalence of Arthritis and Arthralgia and Their Associations with Extra-Articular Manifestations in Patients with Behcet's Disease: A Systematic Review and Meta-Analysis
https://pubmed.ncbi.nlm.nih.gov/40637240