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Rob Illingworth

@illingworth-lab.bsky.social

Group leader at the Centre for Regenerative Medicine (IRR), University of Edinburgh. Exploring the epigenetic mechanisms the control neurodevelopment. Scientist, Dad and lover of all things outdoors!

85 Followers  |  154 Following  |  3 Posts  |  Joined: 11.07.2025  |  1.6004

Latest posts by illingworth-lab.bsky.social on Bluesky

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Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model - npj Parkinson's Disease npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions!

Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:

www.nature.com/articles/s41...

24.07.2025 10:57 — 👍 12    🔁 4    💬 1    📌 0
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We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

23.07.2025 23:38 — 👍 43    🔁 19    💬 1    📌 0

Thanks Pradeep. Hope all is well with you. Looking forward to seeing you in September.

12.07.2025 09:32 — 👍 1    🔁 0    💬 0    📌 0

Thanks Elias, look forward to catching up soon.

12.07.2025 09:31 — 👍 1    🔁 0    💬 0    📌 0
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H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...

12.07.2025 00:50 — 👍 45    🔁 16    💬 2    📌 0

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