Ali Özgür Argunsah

Development of visual-stimulus reversal learning-memory in mice is dependent on social interaction | Ali Özgür Argunşah Excited to share our new collaborative work with the Pryce Lab! In this study, Sarah Wicki and colleagues show that the development of visual‑stimulus reversal learning and long‑term memory in mice i...

www.linkedin.com/posts/arguns...

How does the brain build itself? 🧠📈

Join us on Dec. 9, 10-12pm PT for a webinar presenting the findings from 12 papers mapping brain development in new detail.

🔗 https://alleninstitute-org.zoom.us/webinar/register/WN_phxk87APQh-kgRYqp0jO5Q#/registration

Image: Jasiek Krzysztofiak/@nature.com

Another nail in the coffin for PCA?

- doesn’t linearize, distorting similarity metrics
- is biased by temporal jitter across epochs
- may miss important dimensions for transient amplification

If you think there is a state space, use a state space model!

doi.org/10.7554/eLif...

Local Inhibitory Dynamics Underpin Temporal Integration and Functional Segregation between Barrels and Septa in the Mouse Barrel Cortex Just as separated digits and repeated sampling enhance somatosensation in humans, mice sense objects through multiple segregated whiskers through successive contacts. Individual whisker identity is ma...

www.biorxiv.org/content/10.1...

Science Matters. 🔬
For 80 years, science has been a north star for the U.S. In 1945, Vannevar Bush’s report Science, The Endless Frontier called for bold government investment in research transforming our health, economy, quality of life. Science is not zero-sum—it creates value and better lives.

Learning reorganizes dendritic and stabilizes axonal initial segment inhibitory synapses in CA1 pyramidal neurons Structural synaptic plasticity underlies the changes in brain connectivity required for learning and memory. Inhibitory synapses (INS) target all subcellular domains of excitatory pyramidal neurons (P...

New collaboration: Compartmentalization and stabilization of inhibitory synapses in CA1 after fear conditioning. www.biorxiv.org/content/10.1...