@cvdash.bsky.social
This is a hard read from Paul Bieniasz, the tragedy is that the end of this nightmare doesn't seem anywhere close.
www.theguardian.com/commentisfre...
Thanks to the all the collaborators including the Engelman lab (DFCI/Harvard), the Aiken lab (Vanderbilt University Medical Center), the Campbell lab (Loyola University), the Hultquist lab (Northwestern University), and the Balasubramaniam lab (Meharry Medical College School of Medicine).
10.04.2025 14:44 — 👍 1 🔁 0 💬 0 📌 03/n. In infected cells, HIV-1 integration was also reduced, and this reduction was not a consequence of lower reverse transcription or nuclear entry.
Collectively, this study suggested that CPSF6-CA interaction regulates PIC function both in vitro and in infected cells.
2/n. To study CPSF6's role in HIV-1 integration, we extracted PICs from cells depleted of CPSF6 or expressing a CPSF6 mutant that cannot bind to CA. These PICs exhibited significantly lower integration activity, suggesting a direct role of CPSF6 in PIC function.
10.04.2025 14:44 — 👍 0 🔁 0 💬 1 📌 0
Exciting news. Finally, our CPSF6 paper is published in the JVI.
journals.asm.org/doi/10.1128/...
Key highlights-
1/n. CPSF6 binds to HIV-1 capsid and promotes integration targeting. Yet, CPSF6's effect on the HIV-1 preintegration complex (PIC)-the complex that carries out integration is unknown.
🧑🤝🧑 Social Sciences & Public Policy
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benion Grieving a wasted life At a point in life when there are far too many days behind than ahead, one tends to re-elected in contrast to standing up for the reflect on a life lived. In my lifetime decades greater good? were devoted to protecting America. Sacri A compromised Supreme Court recently fices were made both by myself and my fam- trotted out a shallow token standards of Ily in military service. The tip of the spear: conduct for themselves. Apparently it's Countless weeks over the years were spent not a bribe to accept favors after a deci-sion; only before. Corporations are people? living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since. way?" The purpose: if required, be airborne Pay-to-play is the theme of the day. Un- in minutes on a one-way trip bringing a challenged and uncontested blatant conflicts nuclear Armageddon to an adversary. Fly: of interest abound. The rule of law is situ- ing the unfriendly skies over North Viet- ational if adhered to at all. America can no nam provided a brief interlude, but overall, longer be trusted. The unbridled pursuit of this long line of silent sentinels stood firm power and wealth driven by unquenchable to protect America by deterring external greed has left service above self and Con- threats to our freedoms and way of life stitutional norms in the dustbin of a quaint across the decades. I was privileged to serve past. with men and women of integrity imbued Recently the VA said exposure to Agent with a sense of service. Orange is the probable cause of the can- I'm truly grateful that the B-52s we flew, which were built tough, were engineered cers I live with. Actually I suspect it's more from yet unspecified sources, which cause on scientific principles and fabricated by experienced, skilled workers rather than military pilots to have significantly higher founded on mere beli…
This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.
11.03.2025 22:04 — 👍 26474 🔁 9677 💬 1077 📌 1155This is great. Having similar data for each city or town would add further value.
12.03.2025 15:15 — 👍 1 🔁 0 💬 0 📌 0
