Marina Lusic

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction - Nature Metabolism CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and ...

Very happy to have contributed to this exiting story on nuclear softening caused by metabolic switch caused by oncometabolite 2-HG causing whitening of the brown adipocytes Trifunovic lab CECAD Cologne softeninghttps://www.nature.com/articles/s42255-025-01332-8?utm_source=dlvr.it&utm_medium=twitter

Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥

Q4ddPCR (May the Fourth Be Precise): A Flexible, 4-Target Assay for High-Resolution HIV Reservoir Profiling Precise and scalable quantification of the genetically intact HIV reservoir is critical for advancing curative strategies. However, current HIV reservoir assays such as the intact proviral DNA assay (...

Our preprint is out! Q4ddPCR is a 4-target ddPCR assay for high-resolution HIV reservoir profiling validated on proviral sequences and across multiple cohorts. It supports HIV cure trials where precision matters.
Thanks to Rachel Scheck, Brad Jones & all co-authors.
www.biorxiv.org/content/10.1...

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency Republicans on spending committee push back against proposed reorganization and overhead cuts

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency | Science | AAAS www.science.org/content/arti...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress @cellcellpress.bsky.social @mitchguttman.bsky.social
www.cell.com/cell/fulltex...

How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states Online now:

Deutschlandkarte der Verteilung der Exzellenzcluster auf Bundesländer und Universitäten.

Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

Integrator loss leads to dsRNA formation that triggers the integrated stress response Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

Great work on 3D chromatin from @becklab.bsky.social led by @jpkreysing.bsky.social and @sergiocruzleon.bsky.social in primary human resting CD4 T cells! Very happy to have contributed !

We are witnessing the destruction of science in America | Paul Darren Bieniasz If we stay on this administration’s course, future life-saving medicines may never be invented

An excellent view of the current state of the affairs in US science by Paul Bieniasz

www.theguardian.com/commentisfre...

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells - PubMed Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor prognosi...

But ecDNA do not form hubs

pubmed.ncbi.nlm.nih.gov/36476408/

From enhancer hijacking to ecDNA and onco-condensates – we review how changes in nuclear architecture drive oncogenic gene expression by disrupting enhancer–promoter communication. doi.org/10.1002/ijc..... Kudos to Isabelle Seufert, @claire-vrgs.bsky.social and Sina Wille 👏

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

New paper alert! Anton Goloborodko and international collaborators describe the rulebook defining how molecular motors work together to package and rearrange the DNA for cell division: https://imba.science/41YiAPn

universities and all americans need to band together to fight this threat to american innovation.
China is already excellent at biomedical research and this is just hurting american research.

Predictably, it’s our turn to be viciously targeted by this ruthless, short-sighted and spiteful administration. We will RESIST and I have trust in Cornell leadership to mount a potent defense to protect our community and values and ultimately prevail over this evil.
www.reuters.com/world/us/us-...

X’s dominance ‘over’ as Bluesky becomes new hub for research Data indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover

'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'

Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz

A brain drain would impoverish the United States and diminish world science Europe is advertising itself as a destination for embattled US scientists. It seems many are considering leaving.

For decades, the US has been a magnet for global research talent. According to a poll we ran, many are considering leaving & Europe is advertising itself as a destination for embattled US scientists.

A brain drain would impoverish the US & diminish global science
🧪

www.nature.com/articles/d41...

‘One of the darkest days’: NIH purges agency leadership amid mass layoffs In shock move, four institute directors at the US biomedical agency are removed from their posts.

‘One of the darkest days’: NIH purges agency leadership amid mass layoffs www.nature.com/articles/d41...

🔬 From chromatin dynamics to nuclear compartments, nucleo-cytoskeletal forces, loop extrusion & biomolecular condensates, we break down the machinery modulating DNA repair in nuclear space—with implications for aging & cancer. 🎗️

Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬

📖 Free access: rdcu.be/edViW

Please 🔄 ❤️

This schematic illustrates the interplay between transcription coactivator perturbations (e.g., TIP60 or ATAC complex depletion) and RNA homeostasis. Perturbations lead to alterations in mRNA synthesis, which are counterbalanced by changes in mRNA export and cytoplasmic decay of specific transcripts, thereby maintaining RNA homeostasis.

Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...

What I love most about science are unexpected discoveries-finding what was thought not to exist or imagined differently, even against our hypotheses. We uncover them by following curiosity & intuition. That’s why we’re hosting WoodstockNightScience, to spark bold ideas. Join us! #Science #Innovation

Applications are open for new Schaller Research Group Leader Positions in the field of Infectious Diseases at Heidelberg University. These generously funded positions of 5+2 years are a great opportunity for young virologists!

Find out more here:

www.klinikum.uni-heidelberg.de/fileadmin/in...