David Meyer

Altered translation elongation contributes to key hallmarks of aging in the killifish brain Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the...

Congratulations to our new postdoc Domenico DiFraia for his amazing paper in @science.org! 🥂 A tour de force on brain aging in the killifish. 🐟 Transcriptomics, proteomics, including ribosome profiling, PTMs, etc... Translation is key for understanding brain aging!🧬🎉
www.science.org/doi/10.1126/...

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Thrilled to share that I’ve been selected for the Minerva Fast Track program to launch my research group at @mpiage.bsky.social as part of the @antebilab.bsky.social department! Huge thanks to @maxplanck.de, my mentors Dr. Demetriades & @antebilab.bsky.social, and all who supported me!

The Gutenberg Workshop on the Evolution of Ageing is organized by Margaux Bieuville, Hanna Kokko and Victor Ronget from the University of Mainz together with Edward Ivimey-Cook from the University of Glasgow. The Workshop will take place from 30 September to 2 October 2025 at Wasem's Monastery Engelthal Ingelheim.

Join the GUTENBERG WORKSHOP on the Evolution of Ageing!

Organizers: Margaux Bieuville, @kokkonut.bsky.social and Victor Ronget @unimainz.bsky.social, and eivimeycook.bsky.social @uofglasgow.bsky.social

Info at gutenberg-workshops.uni-mainz.de/evolution-ag...

#ageing #evolution #lifesciences

The deadline for short talk and poster submissions is in less than a week! (15th July!)

Any questions - feel free to DM me!

Thanks for reading! Curious about what’s next? Watch this space for our upcoming perspective on aging 🧪 (7/7)
#OpenScience #Science #SciComm

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the DREAM complex, either by altering individual compon...

Stochastic changes and entropy in aging are often driven by DNA damage. One promising way to reduce this burden? Enhancing repair by downregulating the DREAM complex, an approach we explored here (6/7):
www.nature.com/articles/s41...

Age deceleration and reversal gene patterns in dauer diapause The aging process is characterized by a general decrease in physical functionality and poses the biggest risk factor for a variety of diseases such as cancer, cardiovascular diseases, and neurodegener...

An increase in the biological age, shaped by stochastic changes and entropy, is thought to be irreversible, unless cells divide or die. But in post-mitotic worms, we captured a rejuvenation response and showed that biological age can reset without either.
(5/7):
www.biorxiv.org/content/10.1...

Do all cell types age the same? No!
With our clocks, we discovered that specific neuron types age faster, and these are the ones that degenerate first. Read how we used this insight to identify novel in vivo validated neuroprotective compounds (4/7):
www.researchsquare.com/article/rs-4...

Aging clocks based on accumulating stochastic variation - Nature Aging Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

Is the accuracy of aging clocks evidence for programmed aging? We don't think so!
We show that stochastic noise accumulation alone explains aging clock predictions, and that you can even train clocks on just one biological sample. (3/7):
www.nature.com/articles/s43...

BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy Using Caenorhabditis elegans RNA seq and lifespan datasets we developed a binarized transcriptomic aging (BiT age) clock with a precision close to the theoretical limit of accuracy that can also be a....

BiT age is the starting point for many of the other projects. Our transcriptomic aging clock optimized to highly accurately predict the biological in age of nematodes (2/7):

onlinelibrary.wiley.com/doi/10.1111/...

YouTube video by The Sheekey Science Show How Randomness Drives Aging - DNA Repair, Clocks & Rejuvenation (David Meyer)

I had a great time on The Sheekey Science Show! 🧪

It was fun discussing the stochasticity of aging and potential remedies.

Watch the whole episode 👇
youtu.be/Buj07nWt7o0
#Aging #Longevity

If you are interested in more details: 🧵 (1/7)

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis The authors provide evidence that, together with Dietary Restriction, Rapamcyin and not Metformin, provides a significant lifespan extension in vertebrates.

New paper!

"Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis"

tinyurl.com/yc6pkmbe

Using meta-analysis, we examined the average lifespan extension conferred by dietary restriction (DR), Metformin, and Rapamycin.

Last year's edition of this workshop got so much love by its participants that they simply wanted more. Here we will offer more! We'll force theoreticians to say (final slide of talk) what they wished empiricists would now do & vice versa. Isn't that a cool idea?

Join the Evolution of Ageing workshop led by Dr. Edward Ivimey-Cook. More info: https://gutenberg-workshops.uni-mainz.de/evolution-ageing/ Interested in SORTEE? Contact Edward for details! #workshop

Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...

We are looking for a postdoctoral researcher with bioinformatic expertise to join our research group @molepi.bsky.social @bds-lumc.bsky.social at the LUMC! More details, including the link to submit applications, are provided on the website below.

🖥️🧪

www.lumc.nl/en/about-lum...

I'm looking forward to this meeting!
🧪
Evolution of #Aging

🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽‍🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...

CECAD Scientists Receive DFG Funding for Proteostasis Research A new DFG-funded research group investigates how proteostasis is regulated at the organismal level and its impact on aging and disease.

Congratulations to #CECAD Prof. David Vilchez @thevilchezlab.bsky.social on securing #DFG funding for a new research group on organismal proteostasis!
This project, involving also Prof. Hoppe, will explore how proteostasis regulates #aging and #disease. @dfg.de #Proteostasis

uni.koeln/ZCFFX

We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country.

This Friday, where will you be?

standupforscience2025.org

At Least Now We Know the Truth It’s ugly, but necessary to face.

"We’re witnessing the self-sabotage of the United States"

from @davidfrum.bsky.social
www.theatlantic.com/politics/arc...

This will be a fantastic thread👇
For the top aging preprints also see
www.longevist.xyz/gallery
#GeroSky 🧪

a stack of gift boxes with the words happy boxing day below ALT: a stack of gift boxes with the words happy boxing day below

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day

Starter pack 1: go.bsky.app/VavECSX

Starter pack 2: go.bsky.app/CH1MctZ

Unanswered questions in ageing: an interview with Dr Joris Deelen Joris Deelen obtained his PhD at the Leiden University Medical Center (LUMC) in 2014. In 2016 he joined the Max Planck Institute for Biology of Ageing as a postdoctoral researcher and was promoted to ...

Many thanks to The Biochemist for the interview and opportunity to highlight the ongoing research in my group @mpiage.bsky.social!

portlandpress.com/biochemist/a...

CGC1, a new reference genome for Caenorhabditis elegans The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...

1/12 1. I’m very excited to share the first piece of my postdoc work! www.biorxiv.org/content/10.1...

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...

Very exciting preprint: could stress-induced mutagenesis be adaptive (as opposed to simply a malfunction)? The presence of a mechanism to trigger mutagenesis in response to environmental alterations might indicate that it is an evolutionarily beneficial process

Read our 2 new stories about how neurons 🧠 influence the germline and how their activity can even shape inheritable transposable element expansion 🧪
#Evolutionary_Biology 👇