David Meyer

Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel

A fantastic few days of ageing talks, great people, and excellent food!

Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Ribonucleotide incorporation into mitochondrial DNA drives inflammation

www.nature.com/articles/s41...

Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

You can also read it here
rdcu.be/eG1N7
👇

I am grateful to the reviewers Alan Cohen, Vera Gorbunova, and Steven Cummings for insightful comments that made this piece much clearer. 🙏

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

Aging is the default state of biological systems.
Changing markers picked up by aging clocks won’t roll back time, they only mark it.
The way forward is strengthening repair & maintenance and embracing biology’s messy and stochastic reality.
➡️ www.nature.com/articles/s43... 6/

Aging clocks based on accumulating stochastic variation - Nature Aging Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

We previously showed that stochastic variation alone can create aging clocks predicting age across species & interventions. Because repair & maintenance can never be perfect, small errors inevitably build up, giving rise to aging. www.nature.com/articles/s43...
#Entropy #DNARepair 5/

The accuracy of DNA methylation & other aging clocks has revived programmed and programmatic aging theories. But clocks don’t prove an intrinsic timer. They reflect the accumulation of molecular errors as repair systems are never perfect. #Longevity #Biology 4/

The force of natural selection is strongest during development and wanes after reproduction. Maintenance & repair only need to be good enough for fitness, not perfect, therefore leaving room for gradual decline. #Evolution #DNArepair 3/

Aging started with the very first replicators on earth facing a harsh entropic environment. Life could persist only by evolving repair and maintenance systems to counter damage. Aging and death is therefore the default state, happening because maintenance can never be perfect 2/

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Thank you 🙏

💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.

Thank you for your guidance and inspiration @bjornschumacher.bsky.social

#SIBAwards #bc2basel #Bioinformatics

Aging clocks based on accumulating stochastic variation - Nature Aging Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫

“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.

#Bioinformatics #SIBawards #bc2basel

Thank you for the shout-out!

Aging clocks based on accumulating stochastic variation - Nature Aging Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induced by smoking, calorie restriction, parabiosis and reprogramming.

#bc2basel @SIB PhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation
https://doi.org/10.1038/s43587-024-00619-x

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

FEBS Press Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

Can't wait to be at the #ARDD2025 next week! agingpharma.org

I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.

If you're at the conference, let's grab a coffee and chat!
🧪

#AgingResearch #Longevity #Science

Altered translation elongation contributes to key hallmarks of aging in the killifish brain Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the...

Congratulations to our new postdoc Domenico DiFraia for his amazing paper in @science.org! 🥂 A tour de force on brain aging in the killifish. 🐟 Transcriptomics, proteomics, including ribosome profiling, PTMs, etc... Translation is key for understanding brain aging!🧬🎉
www.science.org/doi/10.1126/...

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Thrilled to share that I’ve been selected for the Minerva Fast Track program to launch my research group at @mpiage.bsky.social as part of the @antebilab.bsky.social department! Huge thanks to @maxplanck.de, my mentors Dr. Demetriades & @antebilab.bsky.social, and all who supported me!

The Gutenberg Workshop on the Evolution of Ageing is organized by Margaux Bieuville, Hanna Kokko and Victor Ronget from the University of Mainz together with Edward Ivimey-Cook from the University of Glasgow. The Workshop will take place from 30 September to 2 October 2025 at Wasem's Monastery Engelthal Ingelheim.

Join the GUTENBERG WORKSHOP on the Evolution of Ageing!

Organizers: Margaux Bieuville, @kokkonut.bsky.social and Victor Ronget @unimainz.bsky.social, and eivimeycook.bsky.social @uofglasgow.bsky.social

Info at gutenberg-workshops.uni-mainz.de/evolution-ag...

#ageing #evolution #lifesciences

The deadline for short talk and poster submissions is in less than a week! (15th July!)

Any questions - feel free to DM me!