Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting Ξ²-lactamase genes in heteroresistance enables resistance of continua of cellular...
We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.
Congrats @jakechoby.bsky.social and team!
rdcu.be/euijW
02.07.2025 18:15 β π 4 π 1 π¬ 0 π 1
@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs!
Congrats, Jake and team on this exciting paper.
02.07.2025 18:07 β π 2 π 0 π¬ 0 π 0
Thanks, Jeff!
10.12.2024 04:00 β π 0 π 0 π¬ 0 π 0
Thanks, Sunny!
10.12.2024 04:00 β π 1 π 0 π¬ 0 π 0
Thanks so much, Lauren! We agree and had never considered this. Big kudos to Julia who was set on investigating this question and persisted through many ups and downs.
02.12.2024 14:42 β π 1 π 0 π¬ 0 π 0
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...
Bactericidal antibiotics release bacterial DNA that activates TLR9, while static antibiotics do not. This can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics to prescribe?
Amazing work by Julia Gross and collaboration with Iain Fraser!
rdcu.be/d1Phk
02.12.2024 14:17 β π 29 π 11 π¬ 3 π 0
Professor and Chair, Department of Microbiology, University of Chicago. Study the pathogenesis of tuberculosis, and other mycobacterial infections. Opinions my own.
Microbiology, evolution, and bacteriophages. University of Pittsburgh School of Medicine.
VP for Research, T.H. Smoot Professor
Depts Chemical and Biomolecular Engn, Pathology, Oncology, INBT
Johns Hopkins University
3D multi-omic, CAR T therapy, cell migration and mechanics
Lab: https://wirtzlab.johnshopkins.edu
Emergence and evolution of bacterial pathogens
Complexity in biological systems
Dept. of Host-Microbe Interactions
St. Jude Children's Research Hospital
NSF CAREER. BWF PATH
Professor at Brunel University of London. Into all things Antibiotic Resistance, Drug Discovery, Biofilms and Signalling
We bring researchers and donors together to cure brain disease. #CureOneCureMany
hootbio.com/abf
Researcher at National Research Council Canada
Microbial pathogenesis
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN.
https://parkinsonsroadmap.org/#
Scientist at Duke University. My team studies cell-autonomous immunity to intracellular pathogens and inflammation. Views are my own and do not represent those of my employer.
Evolving better E. coli for 75,000 generations. Prof at MSU, but opinions my own. (Ok, I also speak for billions -- er, TRILLIONS -- of E. coli.)
Website for LTEE: the-ltee.org
Banner pic from NYC, shared by Darwin. (The microbiologist, not the other one.)
The Antimicrobial Innovations Centre (AMIC) at Brunel University, London | Focused on driving, understanding, and developing solutions to the antimicrobial resistance crisis | https://www.brunel.ac.uk/research/Centres/antimicrobial-innovations-centre
Professor of Life Sciences & Director Global Health Institute @EPFL_en. Passionate about science π€© Views are my own.
Australian first | Scientist second | Associate Professor at The University of Vermont | FirstGen | Lover of germs, especially Salmonella and their type III secretion systems
Posts by Shankar Iyer, editor of Trends in Microbiology.
Associate Professor at the University of Illinois Chicago. Interested in host-microbe interactions. π¬π¨βπ¬π¦ π³οΈβπ
AMR Antimicrobial Resistance
Fernanda C. Petersen,
Professor, University of Oslo and
Ulf R. Dahle,
Specialist Director,
Norwegian Institute of Public Health
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
https://www.nature.com/neuro/
Professor of Medicine, McMaster University
Executive Director of the Firestone Institute for Respiratory Health
Board of Directors Lung Health Foundation
#macrophages #aging #respiratoryinfections #vaccinations #immunity #inflammation #scicomm
Gut microbiome, bacterial pathogens, bacteriophages.
Assistant Professor, Depts. Medicine and Medical Microbiology & Immunology, University of Wisconsin-Madison. Views expressed = mine. hrycklab.medicine.wisc.edu
