Christian Steinmetzger

1H R1ρ Relaxation Identifies a Hidden Intermediate in DNA Base-Pairing 1H R1ρ Relaxation dispersion (RD) NMR experiments provide valuable atomic-level insights into transient, high-energy conformational states of biomolecules. However, cross-relaxation artifacts can hamp...

Check out our latest #NMR study together with @stonebutcher.bsky.social at @katjapetzold.bsky.social lab on an intermediate state of #DNA existing between the well-known Watson–Crick-Franklin and Hoogsteen base pairs stabilised by an anticancer drug Actinomycin D www.biorxiv.org/content/10.1...

Check out our new method for targeted DNP-enhanced NMR of RNA using site-directed spin labeling, now live as a preprint on ChemRxiv:

doi.org/10.26434/che...

A fruitful collaboration with my colleague @rubindg.bsky.social and the group of Prof. Snorri Th. Sigurdsson from the University of Iceland.

If you are there: come see me at poster 110 on Tuesday and Thursday to learn about new developments in nucleic acid DNP measurements

Checked in at Asilomar and looking forward to a week of exciting science at the #ENCISMAR2025 conference in sunny Pacific Grove

Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI - Nature Chemical Biology Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches ...

A new paper from the Hoebartner Lab @UniWue @chlab.bsky.social reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity

www.nature.com/articles/s41...

Perspective: on the importance of extensive, high-quality and reliable deposition of biomolecular NMR data in the age of artificial intelligence - Journal of Biomolecular NMR Artificial intelligence (AI) models are revolutionising scientific data analysis but are reliant on large training data sets. While artificial training data can be used in the context of NMR processin...

Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat

doi.org/10.1007/s108...

Hi Team #NMRchat #NMR. Happy to see you out here!

Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.

Oral Abstract Deadline: January 10

www.enc-conference.org/enc-ismar-2025

For the season that’s in it an NMR advent calendar for us Chemistry Nerds #Chemistry

www.nmr.chemistry.manchester.ac.uk/advent24/

📣📣 XIVth international conference on #NMR a tool for biology. May 26-28, 2025 @pasteur.fr Paris, France. The registration is open 👉 www.nmr2025.conferences-pasteur.org
Coorganized with
@brukercorporation.bsky.social

The data browser used to be quite unreliable and slow for me in 4.x (at least on MacOS). TS 4.4.1 has significantly improved on that and now it works well again