Yuval Nir

Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment Nature Neuroscience - Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop...

Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment:

rdcu.be/ezjNt

Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult Attention-Deficit/Hyperactivity Disorder Background Attention-Deficit/Hyperactivity Disorder (ADHD) is characterised by behavioural variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). ...

Sleep-like Slow Waves During Wakefulness Mediate Attention and Vigilance Difficulties in Adult ADHD

www.biorxiv.org/content/10.1...

A role for the thalamus in danger evoked awakening during sleep - Nature Communications The extent to which the sleeping brain can discern safety from danger is poorly understood. In mice, the authors show that centro-medial thalamic neurons detect threat-related sounds and selectively t...

www.nature.com/articles/s41...

Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment - Nature Neuroscience Pathological neural communication drives the spread of the epileptic network and contributes to memory impairment in focal epilepsy. The authors show that closed-loop electrical stimulation in rodents...

www.nature.com/articles/s41...

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep | Science www.science.org/doi/10.1126/...

Had a brilliant time at #SXSWLondon Corundum Neuroscience panel discussing the future of sleep - issues ranging from monitoring health, through unique interventions, recording EEG via earbuds, to disengaging from ruminations falling asleep & lucid dreaming w/ Caroline Lustenberger, Simon Bachmann

So very proud of our own @OmerBenBarak1 who received the prestigious Sieratzki PhD scholarship for her research on pupillometry and gaze imaging in closed eye conditions, well done Omer!

Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Astrocytes.. we having been paying enough attention:

www.science.org/doi/epdf/10....

Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.

www.nature.com/articles/s41...

Very Cool work. Seems body and brain are somewhat related... who would have guessed

Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.

Interictal network dysfunction and cognitive impairment in epilepsy - Nature Reviews Neuroscience Epilepsy is often associated with cognitive comorbidities that lack effective treatment options. In this Review, Gelinas and Khodagholy discuss how physiological neural networks involved in cognition ...

www.nature.com/articles/s41...

Check out our new publication - "SleepEEGpy" - a python-based pipeline for sleep EEG preprocessing/visualization/analysis, work led by @falach.bsky.social

Another co-first added during revisions

How infant brains fold: Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure Cortical folding begins in utero as sulci emerge and continues postnatally as sulci deepen. However, the timeline and mechanisms underlying postnatal sulcal development remain unknown. Using structura...

Curious how infant brains fold?
I’m excited to share our new study spearheaded by Sarah Tung and Vaidehi Natu now on bioRxiv!
www.biorxiv.org/content/10.1...
Sarah and Vaidehi examined how the grooves of the brain (sulci) develop in individual infant’s brain during the first year of life.

Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila - Nature Neuroscience Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with...

Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila 🧪🧠

www.nature.com/articles/s41...

Natural Neuroscience Natural neuroscience departs from the classical reductionist approach, which emphasizes control at the expense of natural behaviors, by proposing a shift tow...

Nachum Ulanovsky's book "“Natural Neuroscience” on taking a more ecological approach to neuroscience came out! Nachum is one of the world leaders in studying the brain using bats, and his studies are always incredibly interesting and original.
mitpress.mit.edu/978026204499...

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of these oscillations is nece...

A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...

My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.

Celebrating spring holidays with lab yoga and picnic, thanks Revital Hershkovich for great lesson! Happy Passover

Fantastic #inTRACE conference in Parma, bridging neuroscience and clinic in intracranial recordings & stimulation, non-invasive measures, sleep, modeling. Attending with clinical partners Ido Strauss and Firas Fahoum, huge thx to organizers Andrea Pigorini Pietro Avanzini Nigruada hospital team

A role for respiration in coordinating sleep oscillations and memory consolidation Memory consolidation is thought to rely on the interplay of sleep-related brain oscillations. Drawing on recent findings that highlight the influence of respiration on these rhythms, we outline a fram...

In our recent @cp-trendsneuro.bsky.social forum article www.cell.com/trends/neuro..., we highlight respiration's potential role in coordinating sleep oscillations and memory consolidation. With the fabulous @tschreiner.bsky.social and @estebanbt.bsky.social

Excited to share on my first post on Bluesky our new paper in NHB examine the innate and developing aspects of the wiring of the visual system. Congratulations to @emilykubota.bsky.social and the baby MRI team on this important work

👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social

Group meeting with touches of Purim holiday

Sleep spindles as a predictor of cognitive motor dissociation and recovery of consciousness after acute brain injury - Nature Medicine In acutely brain injured patients, well-formed sleep spindles on EEG were more likely present in patients with cognitive motor dissociation, were associated with a shorter time to recovery of consciou...

www.nature.com/articles/s41...

The night’s watch: Exploring how sleep protects against neurodegeneration Parhizkar and Holtzman discuss how sleep disturbances may serve as both an early indicator and potential driver of neurodegenerative diseases, particularly in Alzheimer’s, while reviewing mechanisms u...

The night’s watch: Exploring how sleep protects against neurodegeneration: Neuron www.cell.com/neuron/fullt...

Touchless short-wave infrared imaging for dynamic rapid pupillometry and gaze estimation in closed eyes - Communications Medicine Ben Barak-Dror et al. present a short-wave infrared imaging method for touchless monitoring of pupillary light reflex (PLR) and gaze direction in closed eyes. Data obtained is comparable to that obtai...

I hope that soon tracking pupil during sleep through closed eyes will also become a reality:
www.nature.com/articles/s43...

Pupil size reveals arousal level fluctuations in human sleep - Nature Communications Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...

Such a cool study! congrats @Manu_C_D, @lustenca @anita_luthi and team: www.nature.com/articles/s41...

How does the brain work in natural scenarios, in multi-animal societies of wild animals? 🧠 🧪 🦇

doi.org/10.1126/scie...

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