Bryan Roth

JCI - Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression www.jci.org/articles/vie...

My recent email to @NIHDirector_Jay
@RobertKennedyJr
Please RT!

My recent email to @NIHDirector_Jay
@RobertKennedyJr
Please RT!

My 'animal-free' solution for identifying valid molecular targets Everything versus Everything: EvE Bio

My modest solution for revolutionizing drug discovery in an 'animal-free' manner:
open.substack.com/pub/zendudes...

My 'animal-free' solution for identifying valid molecular targets Everything versus Everything: EvE Bio

My modest solution for revolutionizing drug discovery in an 'animal-free' manner:
open.substack.com/pub/zendudes...

Intracrine FFA4 signaling controls lipolysis at lipid droplets - Nature Chemical Biology An ‘intracrine’ signaling mechanism is proposed whereby a G-protein-coupled receptor (free fatty acid receptor 4) senses locally released fatty acids on intracellular membranes associated with lipid d...

Very, very cool: GPCR signaling in lipid droplets!

www.nature.com/articles/s41...

How to Scale Proteomics A look inside Parallel Squared Technology Institute, a focused research organization trying to make analyzing a proteome as easy as DNA sequencing.

How to Scale Proteomics

press.asimov.com/articles/pro...

A new tragedy for the Endocrine community An outstanding scientist leaves us too soon

Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit Wen et al. reveal that social interaction reduces breast cancer progression by activating ACCGlu→BLAGlu circuits, inhibiting intratumoral sympathetic activity. This neural mechanism enhances antitumor...

"Chemogenetics 'cures' cancer?!"
Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit www.cell.com/neuron/fullt...

MAGA Champion Who Said Trump Would Fight Child Predators Is Arrested on Charges of Being a Child Predator Scott Soucek, the husband of a prominent Wisconsin GOP operative, has been accused of possessing child pornography.

www.thedailybeast.com/maga-champio...

Rapid deep brain chemogenetics: Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals

Rapid deep brain chemogenetics: Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals
www.science.org/doi/10.1126/...

Ebright showed his model was wrong in 1984. He'll be remembered as a legend who developed several new antibiotics and led efforts to expose the single deadliest accident in history, while you continue to promote the single most dangerous campaign of fraud in history.

The only way to cure an egotist from bragging is by surgery--amputation at the neck.

- Evan Esar

Negative data *IS* data....

Don't blame the poor mouse, blame the stupid human who chose the molecular target! 'The fault, Dear Reader, lies not in the mice but in our targets'

Blame the damn human not the poor mouse!
open.substack.com/pub/zendudes...

Don't blame the poor mouse, blame the stupid human who chose the molecular target! 'The fault, Dear Reader, lies not in the mice but in our targets'

Blame the damn human not the poor mouse!
open.substack.com/pub/zendudes...

My opinion on animal models of psychedelic drug action Part Deux

Animal models for psychedelic drug action--my (hopefully) final thoughts and recommendations:
open.substack.com/pub/zendudes...

What killed the competitive renewal at NIH? Following up on yesterday’s whinesplaining about the relative difficulty of getting a NIH grant across pertinent career eras, I had some more thoughts on generational expectations and gasligh…

What killed the competitive renewal at NIH? drugmonkey.wordpress.com/2025/07/31/w...

A hypothalamic circuit that modulates feeding and parenting behaviours - Nature Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

A hypothalamic circuit that modulates feeding and parenting behaviours
nature.com/articles/s41...

In case this is not obvious:

Expecting to understand and predict human biology based solely on modelling nucleic acids is naive.

It’s unrealistic.

You can find these and a million more dose–response curves in this resource article:

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

www.nature.com/articles/s41...

4% payline demoralizing for reviewers - review 9 grants each taking 3-4hrs (total reviewed by all is 90) flying to DC, a hotel conference room to discuss the top half of grants (45) 15 min each, 3x a year for 4 yrs. Paid $300. 4% = maybe 3/90, 0-1 that you reviewed funded. I couldn’t.

No thoughts

In my case this was never made a public proclamation (though I could be mistaken). I would venture they could quickly fix this by aligning all Directors

This is worth a close read...and there is precedence for the Govt's argument, sadly. Many years ago I was told by a PO that the "Director of this institute" had decided to deprioritize research on serotonin. Hence, I would have to give up my 5-HT grant if I wished to be part of a U19 on dopamine!

I then lost all my funding on serotonin receptors until 2017 when NIDA funded my LSD grant! (reporter.nih.gov/search/tv8Wl...)

This is worth a close read...and there is precedence for the Govt's argument, sadly. Many years ago I was told by a PO that the "Director of this institute" had decided to deprioritize research on serotonin. Hence, I would have to give up my 5-HT grant if I wished to be part of a U19 on dopamine!

It’s a motoric, stereotypical response

I fully agree with this take. People get hung up on what the head-twitch response is or is not as a behavior.

It’s more useful to think of head-twitch response as a drug development tool.