Bryan Roth

Avoiding common errors in psychedelic researh D'Oh

Avoiding common errors in psychedelic drug discovery!

open.substack.com/pub/zendudes...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks: Cell www.cell.com/cell/fulltex...

Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors Sodium ions are classically conceptualized as negative allosteric modulators for G protein-coupled receptors, although there have been reports of either positive allosteric modulation or no effect of ...

Huge implications for #GPCR-based drug and sensor design
Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors | pubs.acs.org/doi/full/10....

Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex Dopaminergic transmission within the ventral striatum is broadly implicated in risk/reward decision-making and impulse control, and the rat gambling task (rGT) measures both behaviors concurrently. Wh...

Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex www.jneurosci.org/content/45/4...

No AAVs?

Star Trek The Next Generation scene. The Enterprise D gang is in Ten Forward standing around a beautifully decorated banquet table adorned with exotic flowers and lots of food. Seems like a fancy party is happening, I'm guessing some light chitter chatter is in the background, dishes and flatware tinkling and clanking, maybe some nice soft harpy music, but this is a picture so it's tough to say. Ok, back to the story, so Captain Picard is carving a large round turkey. Bev Crusher, Geordi, Data, and a very very tall Klingon, all in uniform, stand and observe. Closed caption reads, "I shall try some of your burned, replicated bird meat." 🦃

Sorry that I don’t think famous white people (who are mostly horrible people) should be able to pay large amounts of $ to go to an ibogaine or ayahuasca retreat and claim they’ve found healing while the US continues to not care about Indigenous People or access to healthcare 🙃

Biased histamine signaling selectively gates fat preference Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-m...

Biased histamine signaling selectively gates fat preference: Neuron www.cell.com/neuron/fullt...

Biased histamine signaling selectively gates fat preference Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-m...

Biased histamine signaling selectively gates fat preference: Neuron www.cell.com/neuron/fullt...

IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness During sickness, animals exhibit prolonged social withdrawal, a response that may limit disease spread. Elevated IL-1β levels during inflammation activate IL-1R1-expressing neurons in the dorsal raphe...

IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: Cell www.cell.com/cell/fulltex...

Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual proces...

Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...

Properties and functions of transcriptionally distinct enteric neurons Developing genetic access to transcriptionally distinct enteric neurons in vivo enables the examination of morphological heterogeneity across cell types as well as cell-type-specific influences on GI ...

Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...

Properties and functions of transcriptionally distinct enteric neurons Developing genetic access to transcriptionally distinct enteric neurons in vivo enables the examination of morphological heterogeneity across cell types as well as cell-type-specific influences on GI ...

Properties and functions of transcriptionally distinct enteric neurons: Cell www.cell.com/cell/fulltex...

Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual proces...

Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron www.cell.com/neuron/fullt...

Striatal cell-type specific encoding stability and reorganization for agency and habit Adaptive, goal-directed decision making requires agency, knowledge that an action will cause a particular outcome. For well-practiced routines, agency is relinquished in favor of automatic habits. Her...

Striatal cell-type specific encoding stability and reorganization for agency and habit www.biorxiv.org/content/10.1...

When GRC's were cool!

Haven't looked into that. Our ongoing in vivo proximity proteomics results are consistent with this rather skimpy model.

@superkash.bsky.social @markgbaxter.bsky.social
I am King Riffraff

@superkash.bsky.social @markgbaxter.bsky.social
I am King Riffraff

a man wearing a pink shirt that says ' you should get yourself ' ALT: a man wearing a pink shirt that says ' you should get yourself '

The polypharmacological profiles of xanomeline and N-desmethylxanomeline

www.biorxiv.org/content/10.1...

So many “new” ideas are old repackaged ones using updated terms based on current technologies.

Either folks need to read papers from > 5yrs ago. Or they need to cite them so readers & the public see the slow plodding incremental nature of discovery science.

#AcademicSky

My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”

A former Perl Prize awardee….

My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”

Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly

Not sooooo bad: prompt draw a diagram of how 5-HT2A receptor activation induces dendritic spine formation.....I agree with much of this, surprisingly

Amazing paper--must read for #gpcr

The polypharmacological profiles of xanomeline and N-desmethylxanomeline https://www.biorxiv.org/content/10.1101/2025.11.20.689572v1

www.biorxiv.org/content/10.1...

This is a biggie

www.biorxiv.org/content/10.1...

This is a biggie