Shane Liddelow's Avatar

Shane Liddelow

@liddelowsa.bsky.social

Neuroscientist and glial aficionado at NYU Grossman School of Medicine/NYU Langone Health in NYC. Posts in my individual/personal capacity. My lab is full of awesome people doing amazing stuff - check them out: www.liddelowlab.com he/him

2,955 Followers  |  269 Following  |  284 Posts  |  Joined: 07.10.2023  |  2.6799

Latest posts by liddelowsa.bsky.social on Bluesky

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

22.07.2025 19:15 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

fantastic work from @melcooperphd.bsky.social - what are these beautiful networks doing in our brains?

22.07.2025 20:08 β€” πŸ‘ 25    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
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Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.

www.annualreviews.org/content/jour...

18.07.2025 19:31 β€” πŸ‘ 19    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0

On now, last session of #Glia2025, and last presenter from the lab.

S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain

11.07.2025 08:11 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Francesco Limone β€” Liddelow Lab

#glia2025 Liddelow Lab presentations start today!

PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level

T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...

09.07.2025 09:58 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

And a special bonus for #EuroGlia @gliameeting.bsky.social in #Marseilles next week - all the abstracts of the fantastic presentations are available in #Glia

onlinelibrary.wiley.com/toc/10981136...

See you all in a few days - safe travels

03.07.2025 15:45 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Joseph Holden, …, David Calkins
www.psy.vanderbilt.edu/faculty/calk...

Potassium-dependent coupling of retinal astrocyte light response to MΓΌller glia onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Emma Augustin, …, Karine Cambon
www.researchgate.net/profile/Kari...

Hippocampal astrocyte morphology follows an unexpected trajectory with age in a transgenic rodent model of tauopathy onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Andrew Patton, …, Michael Hastings
www2.mrc-lmb.cam.ac.uk/groups/mha/

Multi-omic analysis reveals astrocytic annexin-A2 as critical for network-level circadian timekeeping in the suprachiasmatic nucleus onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Anna Cozzi, …, Sonia Levi
www.unisr.it/en/docenti/l...

Fibroblasts and hiPS-derived astrocytes from CoPAN patients showed different levels of iron overload correlated with senescent phenotype onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Rocio White, …, Shernaz Bamji
www.bamjilab.com

The X-linked intellectual disability gene, ZDHHC9, is important for oligodendrocyte subtype determination and myelination
onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Uxue Balantzategi, Adhara Gaminde-Blasco, …, @bruceappel.bsky.social‬, Elena Alberdi
www.achucarro.org/people/elena-alberdi

AΞ² dysregulates oligo lineage cell dynamics & myelination via PKC in the zebrafish spinal cord onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Mathilde Pruvost …, Patrizia Casaccia
asrc.gc.cuny.edu/neuroscience...

The histone methyltransferases EHMT1 and EHMT2 repress the expression of genes related to excitability and cell death in oligodendrocyte progenitors onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Khulan Batsuuri, …, Miduturu Srinivas
www.sunyopt.edu/faculty-memb...

Targeting connexin 43 in retinal astrocytes promotes neuronal survival in glaucomatous injury onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Niki Ktena, …, Domna Karagogeos
www.imbb.forth.gr/en/research/...

Disruption of oligodendroglial autophagy leads to myelin morphological deficits, neuronal apoptosis, and cognitive decline in aged mice
onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Steffen Kautzmann, …, Christian KlΓ€mbt
neurobio.uni-muenster.de

Cholinergic and glutamatergic axons differentially require glial support in the Drosophila PNS onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Xiaoran Wei, Jiangtao Li, @olsenlab-vt.bsky.social‬

Temporal profiling of male cortical astrocyte transcription predicts molecular shifts from early development to aging
onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025 RESEARCH

Swati Mishra, …, Jessica Young
www.younglaboratory.com

The Alzheimer's disease gene SORL1 regulates lysosome function in human microglia onlinelibrary.wiley.com/doi/10.1002/...

03.07.2025 15:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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#GliaPapers #GliaJuly2025
JULY COVER
Stochastically labeled astrocytes (cyan) and MΓΌller glia (magenta) contacting blood vessels (orange) and neural cell bodies and axons bundles (green) in a mouse retina. (see Holden, JM, et al, doi.org/10.1002/glia...)

03.07.2025 15:43 β€” πŸ‘ 35    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1

Thanks @analog-ashley.bsky.social and @thetransmitter.bsky.social - this was a fun piece to chat about.
Lots of exciting astrocyte work coming out of labs the world over. Watch this space for new insights soon!

30.06.2025 15:07 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1

Strong recommend. Great new PI, excellent institute and resources. Exciting questions to research!

30.06.2025 02:29 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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two women are standing in a store and one of them is saying " all of you " ALT: two women are standing in a store and one of them is saying " all of you "

(SPECIAL GLIA NOTE)
We had 2/9 speakers in 2025 talking about GLIA!
Let's get this number higher in 2026!
Reach out with questions, and submit! Let's spam submissions with all the fantastic glia research going on out there!
It would be great to have submissions from EVERY GLIA LAB IN THE WORLD!

15.06.2025 16:20 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! πŸ‘‰ nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity

15.06.2025 16:20 β€” πŸ‘ 60    πŸ” 40    πŸ’¬ 1    πŸ“Œ 0
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Wolfson Institute for Biomedical Research Established in 1995, the UCL Wolfson Institute for Biomedical Research (WIBR) focuses on fundamental and translational neuroscience within UCL's neuroscience community.

#GliaPapers #GliaJune2025 RESEARCH

Jordan Wright, …, Huiliang Li, William Richardson
www.ucl.ac.uk/medical-scie...

The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
University Medical Center Groningen The University Medical Center Groningen (UMCG) was established in 2005 as a joint activity of the University of Groningen and the Academic Hospital Groningen...

#GliaPapers #GliaJune2025 RESEARCH

Rianne Gorter, …, Wia Baron
campus.groningen.nl/en/onderzoek...

Unexpected remyelination in the absence of matrix metalloproteinase 7
onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Generation of an Inducible Destabilized‐Domain Cre Mouse Line to Target Disease Associated Microglia We developed two mouse strains enabling loxP recombination in either all myeloid cells or inducibly in disease-associated microglia (DAMs). DAMs are a subset of plaque-associated microglia (PAMs) wi...

#GliaPapers #GliaJune2025 RESEARCH

Caden Henningfield, …, Grant MacGregor, Kim Green
@uci-bme.bsky.social

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
University of Science & Technology UST κ³Όν•™κΈ°μˆ μ—°ν•©λŒ€ν•™μ›λŒ€ν•™κ΅

#GliaPapers #GliaJune2025 RESEARCH

Ki Jung Kim, …, C Justin Lee
www.ust.ac.kr/eng/

Astrocyte-specific phenotyping of FAD4T as an Alzheimer's disease mouse model onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss Time-resolved single cell mass cytometry delineates microglial signaling pathways following LPS or Poly(I:C) treatment. Astrocyte presence led to selective reduction of key microglial signaling node...

#GliaPapers #GliaJune2025 RESEARCH

Metin Aksu, …, Yanan Chen
@loyolachicago.bsky.social

AA147 alleviates symptoms in a mouse model of multiple sclerosis by reducing oligodendrocyte loss
onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Myelination Trajectory and Microglial Dynamics Following Repeated Sevoflurane Exposure in Developing Brain Repeated neonatal exposure to sevoflurane induces spatiotemporal changes in developmental myelination and microglial activation.

#GliaPapers #GliaJune2025 RESEARCH

Ji Che, …, Jun Zhang
@fudan-university.bsky.social

Myelination trajectory and microglial dynamics following repeated sevoflurane exposure in developing brain
onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in ...

#GliaPapers #GliaJune2025 RESEARCH

Vidya Ramesh, …, Siddharthan Chandran, @lidazoupi.bsky.social
@edinburgh-uni.bsky.social

The Fragile X messenger ribonucleoprotein 1 regulates the morphology and maturation of human and rat oligodendrocytes onlinelibrary.wiley.com/doi/10.1002/...

05.06.2025 14:44 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@liddelowsa is following 20 prominent accounts