Shane Liddelow

The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...

AMAZING PAPER ALERT!
www.nature.com/articles/s41...

congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team.
This one is important and opens up lots of opportunityes.

Read about one of the fantastic postdocs in the lab - @pryprk.bsky.social.
Thanks to The Scientist for running this exciting series!

Priya is on the job market atm - so keep your eyes peeled for exciting things to come from her lab soon! :-)

#SfN #SocietyForGlia #Astrocytes

ENDING STRONG in Astrocyte land here in San Diego.
Thanks for being an amazing community, and apologies (one last time) for anyone I missed! Please comment below with extra awesome astrocyte sessions.

See you in 2026!

#SfN25 #SocietyForGlia #Astrocytes

penultimate astrocyte sessions for 2025 - let's do this!

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

#SfN #SocietyForGlia
STARTING NOW!

Ending strong with the last www.liddelowlab.com presentations of the week.

@pryprk.bsky.social
talking about a world first mouse model for XDP... and OLIGODENDROCYTES!

@melcooperphd.bsky.social
presenting on astrocyte networks in the mouse forebrain.

PREPRINTS ON THEIR WORK:

Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...)

Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

#SfN25 #SocietyForGlia #Astrocytes

IT'S A BIG DAY - if you're unsure what do do this afternoon - it seems just going to poster row C is the best way to spend some time!

as always, apologies to those I have missed - please comment below with more sessions and presentations!

IT'S A BUSY AFTERNOON FOR THE LAB!

@mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain

Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?)

@liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity

It's a packed day for our researchers at #SfN25. Come say hi!

Astrocytes and oxytoxin - we got you! NOW!

#SfN25 #SocietyForGlia #Astrocytes

Argh! Sorry! THANKS!
There's so many today (and we all know the app is horrible 🫠)

#SfN25 #SocietyForGlia #Astrocytes

Monday is a BUSY day - see you all out there!
(apologies for anyone's presentation I missed - please comment below with details)

#SocietyForGlia #SfN25 #Astrocytes

Sunday is a rest day for astrocytes it seems - but still lots of cool stuff to go and see.
Apologies again for anyone I missed - please link your presentations below

#SocietyForGlia #SfN25 #Astrocytes

Astrocyte presentation round up for Day 1.
Sorry if I missed anyone, please comment below with others!

See you about the conference

#SfN25 #SocietyForGlia #Astrocytes

@borderbiologist.bsky.social presenting now!
Come and learn about a new function for a substate of reactive astrocytes - antigen presentation!

Advances in the genetics and pathology of Lewy body dementia Lewy body dementia is a heterogeneous disease that is underdiagnosed and poorly understood. Pathologically, Lewy body dementia is characterised by the…

Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...

In case you were wondering what to do with precisely 150 minutes of your existence @sfn.org #SfN25 #SanDiego. Join our mini-symposium Single-Cell Multiomics in CNS Injury and Recovery. Guaranteed to contain many glial cells and at least a neuron. I am Co-chairing with Naomi Habib

(bonus)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)

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preprints:

@melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/

@mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1...

@pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

See you in San Diego

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.

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A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1

We've been doing some amazing stuff outside the astrocyte realm.
Check out our latest Oligo investigation led by @pryprk.bsky.social !

Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/astrocytes/a...

thanks for the great insights!

Astrocyte networks span large swaths of brain The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Great story in the @thetransmitter.bsky.social today by
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.

Read the story here: www.thetransmitter.org/astrocytes/a...

Read the preprint here: www.biorxiv.org/content/10.1...

A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School.
Let the conference begin!

a black and white photo of a crowd of people standing and sitting in chairs . ALT: a black and white photo of a crowd of people standing and sitting in chairs .

are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?

LAST WEEK TO APPLY to be a SPiNES speaker for our next season.

Details and apply here: med.nyu.edu/departments-...

COME AND WOW US!