Shane Liddelow

Astrocyte networks are much larger than previously thought, which “flips the way we think about astrocytes and what their networks may mean,” says @liddelowsa.bsky.social.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/astrocytes/a...

thanks for the great insights!

Astrocyte networks span large swaths of brain The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Great story in the @thetransmitter.bsky.social today by
@callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks.

Read the story here: www.thetransmitter.org/astrocytes/a...

Read the preprint here: www.biorxiv.org/content/10.1...

A fantastic time with an excellent group of trainees at the @neurochemistry.org Advanced School.
Let the conference begin!

a black and white photo of a crowd of people standing and sitting in chairs . ALT: a black and white photo of a crowd of people standing and sitting in chairs .

are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?

LAST WEEK TO APPLY to be a SPiNES speaker for our next season.

Details and apply here: med.nyu.edu/departments-...

COME AND WOW US!

Talks will be followed by audience Q&A
Speakers:
Dr Mollie Lobl, Pediatrician, Montefiore Einstein
Alison Singer, Pres &Co-founder, Autism Science Foundation
Dr Chiara Manzini, Assoc Prof, Rutgers U
Dr Karin Knobe, Global Head of Dev, Rare Diseases, Sanofi
Dr Annie Maguire, Postdoc, Einstein Med

The American Society for Neurochemistry (ASN) and the International Society for Neurochemistry (ISN) are hosting a discussion on autism, with clinical, research, family, & pharma perspectives.

August 17, 2025
2-4 PM
Hunter College, West Room 714

FREE
Registration recommended: lnkd.in/dJY7hp-b

Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury Microglial NF-kB signaling increases M1-like spinal microglia over time after spinal cord injury. Microglial NF-kB signaling broadly affects gene expression in spinal cord. Microglial NF-kB signalin...

#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH

@micaelaoreilly.bsky.social , …, Veronica Tom

Microglial IKKβ alters central and peripheral immune activity at distinct time points after spinal cord injury
onlinelibrary.wiley.com/doi/10.1002/...

Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology In a pre-symptomatic mouse model of Alzheimer disease, despite higher amyloid-β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point ...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Thomas Chaigneau, …, Slavica Krantic

Subtle alterations in hippo. neuronal activity coincide with early sex-specific differences in amyloidosis & microglia in a pre-symptomatic mouse model of AD-like pathology
onlinelibrary.wiley.com/doi/10.1002/...

Nuclear Profilin‐1 for DNA Damage Repair Is Involved in Phagocytic Impairment of Senescent Microglia Cytosolic PFN1 relocates to the nucleus for DNA repair. Senescent microglia show nuclear PFN1 accumulation. Nuclear F-actin impairs phagocytosis in senescent microglia. Cytochalasin D failed to retu...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Chan Rim, …, Minyeop Nahm, Min-Soo Kwon

Nuclear Profilin-1 for DNA damage repair is involved in phagocytic impairment of senescent microglia onlinelibrary.wiley.com/doi/10.1002/...

Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel pepti...

#GliaPapers #GliaAugust2025 @wiley.com m RESEARCH

Binri Sasaki, …, Nobuharu Suzuki

Myelin formation by oligodendrocytes is enhanced through laminin-411 and its derived peptide
onlinelibrary.wiley.com/doi/10.1002/...

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine Astroglial CB1 mediate long-term depression in the NAc through purine release. Amphetamine occludes LTD in male mice by inducing the saturation of A1 receptors. Astroglial CB1 mediate behavioral amp...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Yamuna Mariani, …, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo

Astroglial CB1 reveal sex-specific synaptic effects of amphetamine onlinelibrary.wiley.com/doi/10.1002/...

Death in the Taste Bud: Engulfment of Dying Taste Receptor Cells by Glial‐Like Type I Cells Dying taste cells display morphologies consistent with apoptosis. Glial-like Type I cells engulf dying neighbors, perhaps acting as ‘undertakers’. No Type I cells display signs of apoptosis–all earl...

#GliaPapers #GliaAugust2025 @wiley.com om
RESEARCH

Courtney Wilson, …, Thomas Finger

Death in the taste bud: engulfment of dying taste receptor cells by glial-like type I cells onlinelibrary.wiley.com/doi/10.1002/...

The Aquaporin‐4 Expression and Localization in the Olfactory Epithelium Modulate the Odorant‐Evoked Responses and Olfactory‐Driven Behavior AQP4ex and OAP-forming AQP4M23 are expressed in non-neuronal cells of the olfactory epithelium. AQP4ex-KO and OAP-null mice show reduced cell density, including OSNs, and impaired odor responses and...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Donatella Lobraico, …, Michele Dibattista, Antonio Frigeri

The aquaporin-4 expression and localization in the olfactory epithelium modulate the odorant-evoked responses and olfactory-driven behavior
onlinelibrary.wiley.com/doi/10.1002/...

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte-mediated neurotoxicity. FABP7 silencing attenuates NF-κB-dependent transcriptional response during en...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Mariana Bresque, …, Marcelo Vargas

FABP7 expression modulates the response of astrocytes to induced endotoxemia onlinelibrary.wiley.com/doi/10.1002/...

Starvation Induces Upregulation of Monocarboxylate Transport in Glial Cells at the Drosophila Blood–Brain Barrier We identify Yarqay, a proton-coupled monocarboxylate transporter in Drosophila glial cells, which mediates starvation-induced transport at the blood-brain barrier, acting as a novel component of the...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Andrés González-Gutiérrez, …, Jimena Sierralta

Starvation induces upregulation of monocarboxylate transport in glial cells at the Drosophila blood–brain barrier
onlinelibrary.wiley.com/doi/10.1002/...

Astrocyte Extracellular Matrix Modulates Neuronal Dendritic Development In vivo neonatal ethanol: increases dendritic arborization inhibits astrocyte translation of CS-GAGs biosynthetic enzymes Chpf2 and Chsy1 reduces CS-GAG levels Chpf2-slienced astrocyte-condition...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Joel Hashimoto, …, Marina Guizzetti

Astrocyte extracellular matrix modulates neuronal dendritic development onlinelibrary.wiley.com/doi/10.1002/...

Role of Cx43 and ACKR3 in Modulating Astrocytic Response and Neuronal Survival Post‐Subarachnoid Hemorrhage ACKR3 interacts with Cx43 to inhibit GJIC in astrocytes in SAH mice. ACKR3 activation promotes Cx43 internalization, inhibiting GJIC and increasing YAP nuclear translocation. Inhibition of GJIC enha...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Jian Yan, …, Tao Hong, Jian Duan

Role of Cx43 and ACKR3 in modulating astrocytic response and neuronal survival post-subarachnoid hemorrhage
onlinelibrary.wiley.com/doi/10.1002/...

Interplay Between Schwann Cells and Peripheral Cancers: Mechanisms and Therapeutic Targets in Cancer Progression Schwann cells drive disease progression via immune evasion, neuronal remodeling, perineural infiltration, spinal glial suppression, and tumor proliferation/migration. Their multifaceted roles positi...

#GliaPapers #GliaAugust2025 @wiley.com RESEARCH

Ziwan He, …, Zhihui Huang, Yongjie Wang
Interplay between Schwann cells and peripheral cancers: mechanisms and therapeutic targets in cancer progression
onlinelibrary.wiley.com/doi/10.1002/...

Neural Stem Cell‐Derived Astrogliogenesis: The Hidden Player of the Adult Hippocampal Cytogenic Niche Neural stem cells can give rise to astrocytes in the adult hippocampus via asymmetric or direct differentiation. Astrogliogenesis is regulated by intrinsic and extrinsic factors. Impaired astrogliog...

#GliaPapers #GliaAugust2025 @wiley.com REVIEW

Gonçalo Ferreira, Luísa Pinto

Neural stem cell-derived astrogliogenesis: the hidden player of the adult hippocampal cytogenic niche
onlinelibrary.wiley.com/doi/10.1002/...

#GliaPapers #GliaAugust2025 @wiley.com
AUGUST COVER
Oligodendrocyte binds to laminin on the perivascular basement membrane in the murine cortex at the age of postnatal day 16 (red: CC-1; green: laminin alpha-2; blue: DAPI). (see Sasaki B, et al, doi.org/10.1002/glia...)

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

fantastic work from @melcooperphd.bsky.social - what are these beautiful networks doing in our brains?

Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.

www.annualreviews.org/content/jour...

On now, last session of #Glia2025, and last presenter from the lab.

S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain

#glia2025 Liddelow Lab presentations start today!

PS2 | Poster Session II
Wednesday, 9 July 2025, 13:00 - 16:00
Room: Hall Garden Level

T11-059B Understanding specific neuron-astrocyte interactions in neuroinflammation
@sciencelemon92.bsky.social
www.liddelowlab.com/francesco-li...

And a special bonus for #EuroGlia @gliameeting.bsky.social in #Marseilles next week - all the abstracts of the fantastic presentations are available in #Glia

onlinelibrary.wiley.com/toc/10981136...

See you all in a few days - safe travels

#GliaPapers #GliaJuly2025 RESEARCH

Joseph Holden, …, David Calkins
www.psy.vanderbilt.edu/faculty/calk...

Potassium-dependent coupling of retinal astrocyte light response to Müller glia onlinelibrary.wiley.com/doi/10.1002/...

#GliaPapers #GliaJuly2025 RESEARCH

Emma Augustin, …, Karine Cambon
www.researchgate.net/profile/Kari...

Hippocampal astrocyte morphology follows an unexpected trajectory with age in a transgenic rodent model of tauopathy onlinelibrary.wiley.com/doi/10.1002/...

#GliaPapers #GliaJuly2025 RESEARCH

Andrew Patton, …, Michael Hastings
www2.mrc-lmb.cam.ac.uk/groups/mha/

Multi-omic analysis reveals astrocytic annexin-A2 as critical for network-level circadian timekeeping in the suprachiasmatic nucleus onlinelibrary.wiley.com/doi/10.1002/...