ぜのぱす

There is no replacement (yet) for animal models in medical research The NIH is “reducing animal use in research.” But there is no replacement for animal models.

www.statnews.com/2025/05/19/a...

トランプ政権がWikipediaの運営団体を脅迫 - GIGAZINE ドナルド・トランプ大統領がワシントン連邦地検の検事正代行に指名したエド・マーティン氏が、Wikipediaの運営組織であるウィキメディア財団に対し、非営利団体としての地位に疑問を呈する書簡を送付したことが明らかになりました。マーティン氏はWikipediaに対して、「アメリカの免税組織法における義務に違反する可能性のある一連の活動を行っている」と指摘しています。

トランプ政権がWikipediaの運営団体を脅迫║GIGAZINE
https://gigazine.net/news/20250426-trump-doj-threaten-wikipedia/

New England Journal of Medicine gets swept up in U.S. attorney inquiry into alleged bias Last week, at least one scientific journal received a letter from a top U.S. attorney asking it to respond to alleged bias. Now, NEJM has received a similar inquiry as well.

New England Journal of Medicine gets swept up in U.S. attorney inquiry into alleged bias www.statnews.com/2025/04/23/n... via @statnews.com

ハーバードと政権の戦いも、ハーバードが戦う姿勢を見せたら「あの手紙は間違って送っちゃった、てへぺろ」って言い出しましたよ。

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Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...

【memo】

www.nature.com/articles/s41...

『グリーンカード』を持っていても、最近発行されたカードだと空港で拘束されて強制国外退去命令を受けたアジア系女性がいた、という話が出回っている。

さらに、米国内を移動する国内線のフライトでも、ICE職員がランダムに、米国内に合法でいることを証明する書類やIDを見せるよう要求し、持っていないと、飛行機から降ろされて拘束されてるようだ。

アメリカ国籍のひとでも、(白人でなければ)ID提示を要求される可能性が高まってるので、国内便でも必ずパスポートを持って乗った方がいい。

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BREAKING: NIH admits funding freeze is illegal, will resume issuing grants An internal memo issued February 12 was obtained by Popular Information.

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BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
popular.info/p/breaking-n...

Free introns of tRNAs as complementarity-dependent regulators of gene expression Nostramo et al. demonstrate that free introns of tRNAs (fitRNAs) are a previously unknown class of small noncoding regulatory RNAs that bind to complementary sequences on mRNA ORFs, leading to decay. ...

【memo】😳

Free introns of tRNAs as complementarity-dependent regulators of gene expression: Molecular Cell www.cell.com/molecular-ce...

Fig1(A)The cuticle of wild-type G. bimaculatus is uniformly dark brown or black. Head and anterior thorax shown in dorsal view. (A′)Gb-lac2 gene somatic mutagenesis in G0 animals can be detected by presence of white/ light brown spots of cuticle (asterisks). Scale bar:500 μm. (B)Representative cuticle phenotypes of G1Gb-lac2 mutant nymphs at 1 day after hatching. Homozygous mutants (−/−) showed homogeneous pale brown cuticle. Heterozygous mutants(−/+) showed slight reduction in black pigmentation. Control first instar nymphs have dark melanized cuticle by one day after hatching. Scale bar:1 mm. (C)Surveyor assay result. The control experiment, in which PCR product was amplified from the genome of a wild-type control individual, did not produce any band of the expected size after Surveyor endonuclease treatment. In contrast, PCR product amplified from the genome of CRISPR reagent-injected animals included small fragments of expected size after Surveyor endonuclease treatment (arrowhead)

Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket Gryllus bimaculatus

Read this Techniques & Resources Article by Yuji Matsuoka, Taro Nakamura, Taro Mito, Cassandra Extavour & colleagues:
https://doi.org/10.1242/dev.199746

‘Iterative Bleaching Extends Multiplexity’ facilitates simultaneous identification of all major retinal cell types Highlighted Article: A multiplexed immunofluorescence technique called ‘Iterative Bleaching Extends Multiplexity’ (IBEX) was adapted to label all major cell types in the retina. This technique applied...

【memo】

journals.biologists.com/jcs/article/...

JREC-IN | 助教または准教授・講師の公募　（理学研究科生物科学専攻) イノベーション創出を担う研究人材のためのキャリア支援ポータルサイト

お薦めlab!
@ashindo.bsky.social

jrecin.jst.go.jp/seek/SeekJor...

Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed More than 75 laureates have written an open letter describing Mr. Kennedy’s selection for H.H.S. secretary as detrimental to public health.

Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed www.nytimes.com/interactive/...

www.altmetric.com/altmetric-ne...

gigazine.net/news/2024120...

Ex-Prez Ken Cho reps next year’s @socdevbio.bsky.social meeting in advance of his keynote at the 1st Asian Xenopus Conference.

Hard to express the joy of this moment at the first Asian Xenopus Conference. So proud to “break bento” with former trainees @ashindo.bsky.social, @linusben.bsky.social, Tae Joo Park, Hye Ji Cha, and Maki Takagishi. Eating in the Shindo Lab at Osaka University makes it even better.