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Nath Jones

@drnathjones.bsky.social

Researches parasites and how to kill them. Leishmania epigenetics & transcriptional regulation. Currently in York.

400 Followers  |  529 Following  |  3 Posts  |  Joined: 25.10.2023  |  1.5598

Latest posts by drnathjones.bsky.social on Bluesky

Postdoctoral Research Associate We are looking for a talented and enthusiastic Postdoctoral researcher to join the Maclean lab to investigate the metabolism of the human parasite Toxoplasma gondii.

πŸ“£ Open postdoc position in my lab to investigate how Toxoplasma acquires nutrients. Join me at the University of Edinburgh. Closing date 14th August. More details below ⬇️

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

23.07.2025 10:00 β€” πŸ‘ 6    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1
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The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature Microbiology FIKK effector kinases underwent rapid evolutionary expansion and are a druggable target in Plasmodium falciparum.

Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...

23.06.2025 13:28 β€” πŸ‘ 21    πŸ” 7    πŸ’¬ 2    πŸ“Œ 2
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Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...

So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk

27.05.2025 10:28 β€” πŸ‘ 31    πŸ” 12    πŸ’¬ 2    πŸ“Œ 1
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Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...

Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...

24.04.2025 12:11 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Jobs - The University of York

We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun!
jobs.york.ac.uk/vacancy/rese...
@hyms.ac.uk
@ybri-uoy.bsky.social

22.04.2025 09:56 β€” πŸ‘ 9    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Keep VEuPathDB open-access to all by subscribing today! veupathdb.org/veupathdb/ap...

21.04.2025 14:58 β€” πŸ‘ 16    πŸ” 16    πŸ’¬ 1    πŸ“Œ 3
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Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone Nitisinone reduces survival of the malaria-transmitting mosquito Anopheles gambiae by blocking tyrosine catabolism.

Glad this is finally out. Using pharmacokinetic modeling we show that #nitisinone, an FDA-approved drug 4 #Tyrosinemia & #Alkaptonuria, kills #Anopheles mosquitoes, outperforming #Ivermectin. Grateful to all primary author’s & fantastic collaborators!

www.science.org/doi/10.1126/...

26.03.2025 20:21 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Structure and Activity of the Essential UCH Family Deubiquitinase DUB16 from Leishmania donovani In Leishmania parasites, as for their hosts, the ubiquitin proteasome system is important for cell viability. As part of a systematic gene deletion study, it was discovered that four cysteine protease...

New preprint: results from a collaborative project funded by the GCRF Global Network for NTDs investigating Leishmania deubiquitinase 16 as a potential drug target. @ybri-uoy.bsky.social @mottramlab.bsky.social www.biorxiv.org/content/10.1...

04.03.2025 11:03 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Research Assistant/Associate Job PurposeΒ We are seeking to recruit a motivated and creative Research Assistant/Associate (postdoctoral researcher) to work within an MRC-funded research programme https://gtr.ukri.org/projects?...

πŸ₯πŸ₯ Job alertttt!! Interested in weird biology of malaria parasites? Inducible genetic screens? Single-cell RNAseq? Come postdoc with us - www.parafugelab.com ! International applicants or applicants just finishing up their PhD, both welcome!!

www.jobs.gla.ac.uk/job/research...

17.01.2025 11:50 β€” πŸ‘ 27    πŸ” 20    πŸ’¬ 1    πŸ“Œ 6
Bioart

Is there a way to download all of NIH Bioart (in case it is taken offline by the current regime in the USA)?

bioart.niaid.nih.gov/discover

22.01.2025 22:14 β€” πŸ‘ 14    πŸ” 7    πŸ’¬ 3    πŸ“Œ 0

MRC- funded PhD project at the interface between biology & physics to investigate the segregation of an antibiotic resistant plasmid. Interdisciplinary training with super supportive supervisors.

In the beautiful historic city of York.

Please re-post, thanks! #microsky
🦠🧫πŸ§ͺ
πŸ“†17 December

03.12.2023 09:06 β€” πŸ‘ 8    πŸ” 13    πŸ’¬ 0    πŸ“Œ 0

Happy to see this now online at ACS Infectious Diseases . Catherine & the team did a great job on the initial structural & biophysical assessment of BDF5 bromodomains as potential drug targets in Leishmania. #parasite #epigenetics

t.co/UoI9i1NSux

01.11.2023 20:19 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Hello Bluesky

25.10.2023 18:58 β€” πŸ‘ 8    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

@drnathjones is following 20 prominent accounts