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Bone Research is an open access, fully peer-reviewed journal publishing the foremost progress and novel understanding of all aspects of bone science.
TGF-Ξ² and BMP signaling pathways control bone formation and repair. This review maps how these pathways interact with other networks, identifying specific targets for developing drugs to treat osteoporosis and fractures.π
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Electroactive hydrogels use electrical stimulation to accelerate bone regeneration, offering a faster, more effective treatment for fractures and osteoporosis β a promising solution for aging populations.π
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Omega-3 fatty acids may aid spinal cord injury recovery by fighting inflammation and boosting nerve healing. This could lead to new treatments that improve outcomes for victims of such injuries.π
#Omega-3 #bone
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Biologic therapies improve bone healing by 30%, showing promise for treating nonunion fractures and bone disorders. They offer less invasive, more effective treatments and reduce disability and mortality rates, enhancing patient recovery.π
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Nerves aid bone healing by regulating the immune response. This insight could lead to targeted treatments that enhance bone recovery and reduce healing time after fractures.π
#bone #immune
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Periodontitis causes tooth loss by disrupting oral health. This review helps us understand its molecular drivers, aiding in finding new ways to treat and prevent this painful gum disease.π
#periodontitis #bone #gum
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Bone homeostasis and osteoporosis-related challenges in spinal fusion in the vertebrae. This figure illustrates the key biological & mechanical challenges affecting spinal fusion in elderly patients. In normal vertebrae, MSCs within the bone marrow differentiate into osteoblasts, which mature into osteocytes and maintain bone formation. Concurrently, hematopoietic stem cells (HSCs) differentiate into OCs, which mediate bone resorption. Under normal vascular conditions, bone formation and resorption remain balanced. In aged vertebrae, MSCs exhibit impaired osteogenic differentiation, coupled with reduced vascular supply, leading to decreased bone formation. Meanwhile, osteoblasts and osteocytes secrete increased levels of RANKL (receptor activator of nuclear factor kappa-B ligand), disrupting the OPG (osteoprotegerin)/RANKL balance and excessively activating OCs, resulting in accelerated bone resorption. Osteoporosis and degenerative disc changes contribute to fragility in the elderly.
Check out "Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly", by Shuimu Chen & coauthors in JOR Spine: onlinelibrary.wiley....
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Extracellular vesicles (EVs) are tiny bubbles cells release that can carry healing substances. They might help treat osteoarthritis by delivering drugs directly to affected joints, offering a new way to manage this common joint disease.π
#EVs
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Osteoporosis may boost dementia risk in seniors, especially after fractures. Better bone health care could help prevent both, offering new insights for managing aging health.π
#osteoporosis #dementia #bone
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Neurofibromatosis type 1 (NF1) causes spine deformities. New study using a mouse model reveals the cellular cause and suggests a treatment that could prevent these deformities, offering hope for better management of NF1.π
#NF1 #bone
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Bone marrow fluid from newborns boosts stem cells' bone-making abilities more than adult fluid or standard serum, offering a promising tool for healing bone.π
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Overexpressing Ribosomal Protein S17 (RPS17) in immune cells may help treat Ankylosing Spondylitis (AS) by easing inflammation and preventing bone loss, offering a promising new approach!π
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Losing weight can thin your bones too; this review explains why rapid slimming raises fracture risk and how to protect your skeleton while shedding pounds.π
#weight #bone #skeleton
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The brain talks to bones through nerves and chemical messengers; calming this βbrain-bone chatβ could offer new ways to fight osteoporosis and other skeletal diseases, guiding future therapies for healthier aging.π
#bone #brain #osteoporosis
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The Survival of Motor Neuron (SMN) protein is key for bone health by controlling gene function and protein breakdown. Studying it in Severe Spinal Muscular Atrophy (SMA) mice helps understand bone issues in patients, guiding future treatments.π
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A new review study delivers a holistic overview of bone healing! It synthesizes mechanisms (inflammatory balance, repair substance supply), current strategies (bioactive factors, stem cells, smart biomaterials), and cutting-edge biosensor monitoring.π
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Osteomyelitis, a tough bone infection, often recurs despite treatment. This review highlights how biomaterials can direct immune cells to fight infections more effectively, offering hope for better therapies.π
#Osteomyelitis #bone
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Bone marrow lesions (BML) are early signs of osteoarthritis (OA). Researchers studied BML and cartilage interactions, finding that certain cells drive OA progression through inflammation and aging. This helps in developing new treatments for OA.
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By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.π
#Sirt5 #osteoporosis #bone
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Researchers demonstrated in mice that deleting hypertrophic chondrocyte descendants impairs bone growth and healing. This revealed the cells' role in secreting factors such as thrombospondin-4, which is essential for blood vessel formation.π
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Investigating circadian rhythm regulation, a study finds Gala-SR, a small-molecule compound, effectively restores rhythm disorders and mitigates inflammation in periodontitis, offering potential for treating inflammatory diseases.π
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Exploring the links between ossification of the posterior longitudinal ligament and endocrine-metabolic dysregulation, a review highlights potential factors and pathways, crucial for advancing early intervention and therapeutic strategies.π
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Discogenic lower back pain is a distinct pathological entity linked to intervertebral disc degeneration. Recent review synthesizes current knowledge on its pathophysiology, risk factors, and diagnostic challenges, highlighting the need for targeted treatments.π
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Traumatic heterotopic ossification (HO) is an abnormal bone formation after injury. A study explores how necroptotic macrophages and p21-activated kinase 4 (Pak4) influence this process, revealing potential therapeutic targets.π
#bone #Pak4
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Osteoarthritis (OA), a common joint disorder, is a significant global healthcare challenge. This review explores how advanced materials and AI enhance OA diagnosis and treatment, offering insights for next-generation smart materials with improved performance.π
#joint
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cPLA2, a key inflammation mediator, drives cartilage degeneration in osteoarthritis (OA) and intervertebral disc degeneration (IVDD). Inhibiting it reduces inflammation and preserves cartilage, offering hope for new therapies.π
#osteoarthritis
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A new review explores how aging affects osteoarthritis, identifying immune imbalance, cell aging, and stem cell exhaustion as key factors, guiding future treatments.π
#osteoarthritis #cell #bone #aging
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Using bone injury strategies, a recent study explores diabetic patients' foot wound healing, revealing osteokines' role in accelerating repair and offering new treatment insights.π
#bone #diabetic #osteokines
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Dendritic cells play a key role in bone repair and regeneration. New research explores their impact on bone health and potential for innovative treatments in osteoimmunologyοΌπ
#osteoimmunology #bone
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Piezo1, a key protein in bone health, boosts fracture healing by enhancing mitochondrial energy production. A new study shows it works through a pathway involving Ξ²-catenin and Lars2, offering new ways to treat fracturesοΌπ
#Piezo1 #bone #Lars2
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