🍊Amir Dehsarvi

A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease INTRODUCTION With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....

New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD

doi.org/10.1002/alz....

Research Fellow: Medical imaging analysis UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab.

UCL Hawkes Institute seeks postdoc to develop joint text-vision AI models for MRI analysis in dementia and longevity, led by Prof James Cole at MANIFOLD lab. Closing date: 17th October

www.dementiaresearcher.nihr.ac.uk/job/research...

Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...

Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...

Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP

doi.org/10.1002/mds....

How does the brain reorganize in the context of age and AD?

Are functional changes in age and AD similar?

Are these changes dynamic across the age/AD spectrum?

We unpack these questions in a sample of N=973 with AD biomarkers

Preprint: tinyurl.com/ymv8s7h8

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The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended against granting the marketing authorisation of #donanemab ( #Kisunla ) in the treatment of the mild dementia stage of Alzheimer’s disease across the EU and EEA.
www.ema.europa.eu/en/medicines...

نوروز مبارک
با آرزوی سالی سرشار از آزادی، شادی،‌و سلامتی برای همه

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.

doi.org/10.1186/s130...

We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM

Jobs We are working to solve the biggest mysteries in bioscience.

We're now hiring for a Director of our Center for Data-Driven Discovery. The ideal candidate will spearhead efforts to create new methods for representing, analyzing, and interpreting large-scale biological data.

Learn more and apply: alleninstitute.org/careers/jobs...

#compneuro

This is incredibly stressful to our Alzheimer's community (families and researchers). There are Alzheimer Disease Research Centers that are in limbo now - no council meetings means no notice of awards, means all the research we are doing to slow or prevent this disease is paused indefinitely.

Research Assistant: EDoN Initiative (Early Detection of Neurodegeneration) EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis.

EDoN Research Assistant Research Assistant responsible for harmonizing data, linking with traditional phenotypes from clinical assessments, biomarkers, and imaging, and beginning analysis. Closing date: 13th March

www.dementiaresearcher.nihr.ac.uk/job/research...

Project launched to identify new drug target for vascular dementia Vascular dementia is one of the most common types of dementia and is growing in prevalence. There are currently no effective treatments for the condition. A new UK DRI project, funded by the British H...

Fascinating postdoc opportunity with @JingQiuCDBS (UK DRI at Edinburgh) looking at endothelial cell dysfunction in small vessel disease 🧠

🗓️ Deadline: 20 Feb

More about the new project & how to apply 👉 www.ukdri.ac.uk/news-and-eve...

NOT male/men

BUT female/women

Job Opportunity at University of Leeds: Research Fellow in Cognitive Ageing and Brain Imaging Are you looking for an exciting PostDoc position working in brain imaging and cognition? Do you have a PhD or near to completion using imaging methods? Are you interested in how strategies can improve...

A one-year post doc opportunity on an ESRC-funded project at the University of Leeds. Details ->

jobs.leeds.ac.uk/vacancy.aspx...

Get in touch if you'd like to know more!

Senior Research Technician - DEMENTIA RESEARCHER Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre.

Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre. Closing date: 12th February

www.dementiaresearcher.nihr.ac.uk/job/senior-r...

Excited to be chairing a new Stanford faculty search in Neurology. We are looking for MD and MD/PhD physician-scientists who have a strong research program (wet lab or dry lab) and who are also excellent clinicians. Please spread the word. Here's the link to the job posting:
lnkd.in/d6REUGfM

Huge thanks to alzforum for covering our most recent work!
Great summary!

www.alzforum.org/news/researc...

Nice to see Alzforum covering our most recent article in Science Transl Med and highlighting its importance for future lines of research and therapy! Special thanks David Jones and Tarick Pascoal for the great comments on our work!

alzforum.org/news/research-…

Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.

Incredibly happy and proud to share our newest work in
Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner!

science.org/doi/10.1126/...

Thread below

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques

www.medrxiv.org/content/10.1...

Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease | EMBO Molecular Medicine imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...

Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to co-senior Matthias Brendel!

Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key!

doi.org/10.1016/j.ne...

Amyloid-β and tau deposition in traumatic brain injury: a study of Vietnam War veterans De Bruin et al. report that traumatic brain injury does not inherently elevate the Alzheimer’s pathologies amyloid-β or tau, but is associated with their u

Very happy to share the first PhD work by Hannah de Bruin, showing that traumatic brain injury is not linked to higher fibrillar amyloid and tau per se, but to altered patterns of tau deposition preferentially in TBI vulnerable regions
doi.org/10.1093/brai...
@rikossenkoppele.bsky.social

Paper alert: We performed a prognostic validation of the MDS PSP criteria, showing most patients with possible/suggestive PSP show an increase in diagnostic certainty over time. Increase in diagnostic certainty could be used as an endpoint in trials
doi.org/10.1002/mds....

New Insights into NPC: a Form of Childhood Dementia Research underscores involvement of the brain’s immune system

Neuro-#inflammation plays a crucial role in Niemann-Pick type C, a #raredisease associated with childhood #dementia. The research points to a biomarker, a molecule called TSPO, that could be useful in disease monitoring and assessing treatment response.

#neuroscience #neurology #pediatrics

As I've been seeing a lot of job postings here, I've set up a NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for a PhD, Postdoc, or faculty position in Neuro or an adjacent field.

bsky.app/profile/did:...

Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...