Abdel Mazouzi

Palestinian woman in hospital after being clubbed by masked Israeli settler The attacker is seen striking the 55-year-old woman with a large wooden stick during the assault in the West Bank village of Turmus Ayaa.

FINALLY the BBC starts covering what we’ve all already seen.

“A 55-year-old Palestinian woman has been taken to hospital after being clubbed over the head by a masked Jewish settler as she was picking olives.”

Staff Scientist About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Directors The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

Histone Recycling Promotes PARP Inhibitor Resistance Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/

Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!

🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...

Congrats Andre!

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/...

#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance

go.nature.com/45vRWhd

Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out!
Congratulations!! and happy we could contribute a tiny bit.

Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.

This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

Extremely cool!

Thank you for sharing!

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

new out in Nature yesterday www.nature.com/articles/s41...

NASP modulates histone turnover to drive PARP inhibitor resistance Nature - PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Here is the link to get the PDF of our paper in case you don’t have access to Nature: rdcu.be/eAChv

Thanks Sabrina!

Thanks Andre!

I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.

@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.

Congrats Thijn! 🎉 @thijnbrummel.bsky.social

Full article ➡️ bit.ly/40p4KnK

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

JSPS Research Fellowship The Japan Society for the Promotion of Science (JSPS) Research Fellowship supports you as a highly qualified postdoc from Germany in conducting your research in Japan – regardless of discipline.

Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested!
www.humboldt-foundation.de/en/apply/spo...

Great news from The ERC : erc.europa.eu/news-events/...:

SRBD1, a highly conserved gene required for chromosome individualization | Jonne Raaijmakers Excited to share our latest publication in Cell Reports! Our study reveals the critical role of SRBD1, a highly conserved and previously enigmatic essential…

Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience
www.linkedin.com/feed/update/...

Visualizing homology search in living cells Homologous recombination (HR) is a DNA repair process that requires a homologous sequence for the repair of DNA double-stranded breaks. The search for homology is the rate limiting step for HR, but th...

Some DNA damage, RAD51, MND1, cohesin and RAD54L with a lot of imaging! www.biorxiv.org/content/10.1...

Extensive review of 30 years of BRCA1 biology by @sarahmoser.bsky.social and @josjonkers.bsky.social! Such a fascinating protein, and this is probably just the tip of the iceberg of what BRCA1 can do. I am sure more surprises are coming in the next three decades!

Professorship in genetics and molecular cell biology (W3) (f/m/d) - Academic Positions The University of Cologne is one of the oldest and largest universities in Germany. With its six Faculties covering a broad spectrum of disciplines and its i...

*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany

It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer