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Fena Ochs

@fenaochs.bsky.social

The Fena Ochs Lab at the University of Copenhagen 3D chromatin function super-resolved https://www.fenaochslab.org/

1,305 Followers  |  827 Following  |  71 Posts  |  Joined: 12.11.2024  |  2.5858

Latest posts by fenaochs.bsky.social on Bluesky

Exciting Expansion at CGEN! We’re thrilled to welcome Fena Ochs and Niels Erik MΓΈllegaard. πŸ”¬ Fena brings cutting-edge expertise in 3D chromatin organization and its role in gene regulation, DNA repair, and cell division. 🧬Niels Erik’s expertise is in genome structure and DNA helix conformation

30.10.2025 13:59 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Congratulations, Cees! Well deserved πŸŽ‰

24.09.2025 20:07 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics - Nature Structural & Molecular Biology Wei et al. show that the primary function of m6A on the nuclear long noncoding RNA Xist, a master regulator of X inactivation, is to promote RNA degradation. Xist turnover is mediated by the nuclear e...

Double celebration on our floor @oxfordbiochemistry.bsky.social with @guifengwei.bsky.social from the Brockdorff lab and Dounia and Sherry from Fisher lab having their papers published today! And I hear there is more to come...

www.nature.com/articles/s41...

www.nature.com/articles/s41...

09.09.2025 12:22 β€” πŸ‘ 25    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0
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DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Delighted to share our lab's first preprint identifying DDIAS as a mitotic DNA repair protein. Great collaboration with the @andrewblackford.bsky.social, @tcr-miller.bsky.social and @profstewartlab.bsky.social labs, and many more. Read the paper here: www.biorxiv.org/content/10.1...

10.09.2025 19:01 β€” πŸ‘ 26    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Mitotic single-stranded DNA suppression by DDIAS Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

New work from the lab! πŸ”¬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

10.09.2025 16:50 β€” πŸ‘ 47    πŸ” 17    πŸ’¬ 2    πŸ“Œ 0
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DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

10.09.2025 15:18 β€” πŸ‘ 36    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1

What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! πŸ§ͺ Check out the 🧡 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.

13.08.2025 18:16 β€” πŸ‘ 28    πŸ” 10    πŸ’¬ 1    πŸ“Œ 0
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It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

22.08.2025 11:48 β€” πŸ‘ 55    πŸ” 26    πŸ’¬ 2    πŸ“Œ 0
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Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

16.07.2025 16:55 β€” πŸ‘ 105    πŸ” 38    πŸ’¬ 8    πŸ“Œ 1

Congratulations @rberrens.bsky.social !!

17.07.2025 08:10 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Thank you, Nadia!

12.07.2025 08:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I am happy to share that I have been nominated as Eppendorf Award 2025 finalist. It was a wonderful award ceremony, especially as this year's keynote speaker was Professor Sir Steve Jackson, who won the first Eppendorf Award in 1995.
Read more about the event here: lnkd.in/dcRsH3gg

12.07.2025 08:35 β€” πŸ‘ 18    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

29.05.2025 11:26 β€” πŸ‘ 23    πŸ” 35    πŸ’¬ 0    πŸ“Œ 0

I am overjoyed to share that I have been selected as a Lundbeck Fellow 2025. Thank you to @lundbeckfonden.bsky.social for their trust in me - My lab and I cannot wait to get started on this important work.

06.05.2025 18:07 β€” πŸ‘ 13    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Done!

21.04.2025 20:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

All you nuclear biologists out there: Here is a cautionary tale not to be fooled by peripheral organelle staining. It might just be that your antibody got trapped because it is "too good".

16.04.2025 17:15 β€” πŸ‘ 29    πŸ” 11    πŸ’¬ 1    πŸ“Œ 1

Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!

Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!

With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.

See thread below:

11.04.2025 16:05 β€” πŸ‘ 49    πŸ” 16    πŸ’¬ 0    πŸ“Œ 1
Rules of Engagement
YouTube video by Johan Gibcus Rules of Engagement

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...

11.04.2025 07:45 β€” πŸ‘ 98    πŸ” 53    πŸ’¬ 7    πŸ“Œ 6
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6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀π₯𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring πŸ” 𝐏𝐑𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC)Β in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

12.02.2025 14:53 β€” πŸ‘ 46    πŸ” 45    πŸ’¬ 2    πŸ“Œ 7
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🚨#CBC is happening today!

Don’t forgetβ€”our next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!

25.03.2025 07:55 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Cohesin as an essential disruptor of chromosome organization Cohesin is a multi-subunit molecular machine that is able to create lateral chromatin loops within a linear chromosome fiber. Despite intense study, a…

Wonderful, thought-provoking review by Sir Adrian Bird on cohesin loop extrusion as disrupter of chromatin organisation rather than generator. Great read!

www.sciencedirect.com/science/arti...

25.03.2025 07:43 β€” πŸ‘ 21    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info

12.03.2025 14:51 β€” πŸ‘ 7    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0

This is such a cool paper!

27.02.2025 05:20 β€” πŸ‘ 17    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Done!

26.02.2025 09:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Of course!

26.02.2025 09:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Remembering Professor BΓ©la NovΓ‘k 1956 - 2025 With great sadness, we announce the loss of Professor BΓ©la NovΓ‘k.

A brilliant, kind, funny colleague gone too soon. We will miss you Bela.
www.merton.ox.ac.uk/news/remembe...

25.02.2025 16:41 β€” πŸ‘ 20    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0

Well done @fedeteloni.bsky.social and @danielgerlich.bsky.social @gerlichlab.bsky.social πŸŽ‰ Both pools of cohesin (loop extruding and cohesive) contribute to homology-directed repair. Back to back with nice work from Taekjip Ha and Jacob Corn labs!

13.02.2025 16:57 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Works alright for me! Maybe reinstall?

05.02.2025 18:50 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hi chromosome biologists,

now that we're getting more and more connected online, how about starting an international mentorship network?

Postdocs mentor PhDs, young PIs mentor Postdocs, senior PIs mentor young PIs?

Comment or DM if interested, please RT. All input welcome.

05.02.2025 11:36 β€” πŸ‘ 11    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

@fenaochs is following 20 prominent accounts