Mark Goldberg 🧠

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Ok but it’s not power coffee until you add the immersion oil.

I’ve been doing it wrong. . . all these years.

Incredible story of genius, art, and neuroscience.

Incredible story about genius and neuroscience. Thanks for posting it here.

Question Has hospital length of stay increased more for Medicare Advantage beneficiaries than for traditional Medicare beneficiaries since the COVID-19 pandemic?Findings In this cohort study involving more than 89 million hospitalizations from 2017 to the third quarter of 2023, Medicare Advantage beneficiaries experienced disproportionately greater increases in extended hospital stays, especially among those discharged to skilled nursing facilities.Meaning These findings suggest that the Medicare Advantage plan design and practices may contribute to hospital discharge delays, with implications for patient outcomes and hospital capacity as enrollment continues to rise.

New paper w/ Brian McGarry, Ashvin Gandhi, and Drew Wilcock in @jamainternalmed.com!

Hospitals are complaining across the US that patients are "stuck" waiting for rehab beds at nursing homes when they are medically stable and ready for discharge. What is going on??

jamanetwork.com/journals/jam...

Minimal Objective Autonomic Dysfunction in Long COVID

Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia.

Despite heavy symptoms, most showed normal results.

Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon.

www.sciencedirect.com/science/arti...

I think this was a large implementation but maybe these numbers compare just a few selected thrombectomy patients? Wouldn’t make sense for the group as a whole.

US stroke neurologist here. Who can explain the new AI tool that tripled good outcomes and reduced treatment times by one hour, according to this article?

From other sources it seems to be Brainomix CTA software - would that account for such a big improvement in overall recovery?

Great conversation today. Welcome to San Antonio, Sam! Stop by the lab next time you’re virtually here.

Spectacular - I used to know some of this!

These are amazing! Do you still remember it all?

Squid games

That’s what happened to Google search? Proof that one person really can change the world!

Greatly appreciate this review of epigenetic mechanisms underlying regeneration competency only in young animals. Especially timely perspective for those of us puzzling over CNS repair.

Happy Birthday, new Parkland Hospital!

Thrilled to have been with the stroke team that admitted the very first patient, 7:01 AM, 10 years ago *today*!

While I've moved to San Antonio, Parkland still stands as a model for outstanding public hospital care.

www.parklandhealth.org/news-and-upd...

There’s a great addition that could have a sentence in the Sci Am article!

Sadly misleading title. There’s nothing here about making nerves regrow in the adult human brain. Is this how we want to report science advances?

Yeah that didn’t happen. Stroke code #4 and it’s not even 5 pm. Shouldn’t have posted until my stroke week was done.

Photo of many ER beds lined up in hallway, ready for the inevitable rush of simultaneous stroke alerts. Each bed has a sign “STROKE BED. Please do not remove.”

As owner of the stroke service “black cloud” it’s good to see the ED is well prepared for our kind of day.

Spatial transcriptomics reveals human cortical layer and area specification - Nature Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary

Firefly!

Thanks for sharing it.

I didn’t know it was a true story! Timely too: Wikipedia says the ship went down almost 50 years ago - November 1975 - and Gordon Lightfoot recorded his best song just a month later.

Human brain vascular multi-omics elucidates disease-risk associations Reid et al. develop MultiVINE-seq to map thousands of non-coding disease variants to genes in human brain vascular cells. Cerebrovascular disease variants compromise vessel integrity, whereas Alzheime...

Multi-omic underpinnings of Alzheimer's disease promote inflammation (particularly via T cells)whereas those for stroke relate to vascular integrity @cp-neuron.bsky.social
www.cell.com/neuron/abstr...

This image provides details about the paper linked in the post. It was published in the journal Neurorehabilitation and Neural Repair. The title of the article is, "Machine Learning-Based Model for Prediction of Early Post-Stroke Fatigue in Patients With Stroke: A Longitudinal Study".

Post-stroke fatigue can be long-lasting and disabling in patients recovering from a #stroke. New research identified a machine learning-based model that effectively predicted early post-stroke fatigue. Knowing who is at greatest risk can inform treatment. 🧪 🧠🔄 🧠📈
journals.sagepub.com/doi/abs/10.1...

Photo of vivid rainbow in complete arc over mountains in Tuscany.

Spectacular view from the 2025 Gordon Research Conference on CNS Injury & Repair near Barga, Italy. Terrific science happening here.

Double rainbow represents hope that new understanding of plasticity in spinal motor systems may lead to treatments for #stroke and other CNS diseases.

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...

There’s a twist.

The new system was trained to excel with NEJM’s case reports, which are famously so complex and unexpected that they stump the world’s experts. Implications?

Neurology inside joke:

Q: What do you get when you train an LLM using only “zebras” (rare diagnoses)?

A: A bow tie!

Thanks for posting this terrific paper from @erichorvitz.bsky.social and team!

Neurologists will be on board as we traditionally embrace *sequential diagnosis* where each finding generates a new differential, leading hopefully to the best next steps. 1/2

Preprint:
arxiv.org/abs/2506.22405