Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture Synthetic lethality describes a genetic relationship where the loss of two genes results in cell death, but the loss of one of those genes does not. Drugs used for precision oncology can exploit synth...

Happy to share the latest paper from the lab looking at PARP inhibitor responses in isogenic BRCA1 cell line pairs, from the Master work of Shiella Amelia Soetomo and Michael Sharp: dx.plos.org/10.1371/jour...

A huge thank you to the families and participants who made this research possible—your contributions are invaluable. And of course, shout out to Hannah Hovermale, Elissah Granger, and Michael Sharp for their hard work on this project, all collaborators and St Vincent's Institute of Medical Research

We found evidence suggesting that FA is under-diagnosed in Australia, and more testing identifies more cases, and that males are more likely to be tested than females. The reasons behind these observations are unclear and deserve further investigation.

Clinical and genetic spectrum of Fanconi anemia in Australia and New Zealand Fanconi anemia (FA) is a rare genetic condition that predisposes to progressive bone marrow failure, a specific spectrum of malignancies, including he…

I feel incredibly privileged to share this study on Fanconi anaemia, based on a small but important cohort. This work describes the genetics and clinical outcomes of patients in Australia and New Zealand with a diagnosis of FA.

www.sciencedirect.com/science/arti...

Genetic dissection of MutL complexes in Arabidopsis meiosis Abstract. During meiosis, homologous chromosomes exchange genetic material through crossing over. The main crossover pathway relies on ZMM proteins, includ

🚀 Our collaborative work with @monica-pradillo.bsky.social, "Genetic dissection of MutL complexes in Arabidopsis meiosis," is now published in NAR! 🌱 doi.org/10.1093/nar/...
🔬 We show that MutLγ is crucial for ZMM-dependent crossovers, with MUS81 unable to fully compensate for its loss.

A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammals Abstract. Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains

academic.oup.com/nargab/artic...

A high-resolution meiotic crossover map from single-nucleus ATAC-seq reveals insights into the recombination landscape in mammals Abstract. Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains

Beyond advancing our understanding of recombination biology, this approach also opens the door to applications in detecting fertility-related issues and identifying genetic conditions at the single-cell level. Exciting to see where this will lead in the next stage of the project!

Thrilled to share our latest work on meiotic recombination, where we mapped rates and distributions by sequencing thousands of individual sperm. This study was led by Stevan Novakovic and @caitlinharris.bsky.social , in collaboration with @davisjmcc.bsky.social and Cynthia Liu.

Australian Invited Speakers 2025 We are in the process of inviting a number of outstanding Australian leaders in the fields of DNA repair, Cell Cycle and Telomere biology. Current invited speakers include: Lisa Alcock, Curtain Uni…

🦘🧬Australian invited speaker list finalised for the
2025 Cell Cycle, DNA repair and Telomere Meeting!
Friday 5 Sep is your last chance to register at the EARLY BIRD rate & submit an abstract 🤩
australiancellcycle.org/australian-i...

Congratulations Piotr!

Paper accepted! Shout out to co-first authors Hannah Fluhler, Elissah Granger and Michael Sharp.

Complete human recombination maps - Nature Complete human recombination maps are presented that enable exploration of both cross-over and non-cross-over events during meiosis, with the potential to provide insight into the causes of aneuploidi...

www.nature.com/articles/s41...

Meiosis: Exploring diversity to discover the fundamentals Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

Clinical and Genetic Spectrum of Fanconi Anaemia in Australia and New Zealand Fanconi anaemia (FA) is a rare genetic condition which predisposes to progressive bone marrow failure, a specific spectrum of malignancies including head and neck squamous cell carcinoma (HNSCC), and ...

A recent preprint from the team, about the clinical and genetic spectrum of Fanconi anaemia in Australia and New Zealand. It also underscores the value of higher testing rates in detecting more cases.

www.medrxiv.org/content/10.1...

Thanks to the team for a great year and a very chilled end of year lunch in Carlton gardens.

Congratulations to Shiella Amelia Soetomo on completing an excellent Masters thesis on developing tools to measure synthetic lethality. Shout out to co-supervisor Michael Sharp!