Congratulations to first authors @susankilgas.bsky.social and Ariana Bratt, as well as to all other authors.
02.09.2025 17:05 — 👍 2 🔁 0 💬 0 📌 0
Pharmacologic interrogation of USP28 cellular function in p53 signaling
Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28
probe, alongside a control compound and an inhibitor-resistant mutant. They show that
USP28 inhibition mimics p53 path...
Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...
02.09.2025 17:04 — 👍 13 🔁 3 💬 1 📌 1
🧬 Calling grad students & postdocs in genome stability/oncology: don’t forget to register for the 2026 Gordon Research Seminar runs Feb 28–Mar 1, Ventura, CA. Keynote: @chowdhurylab.bsky.social. Abstracts due Nov 23, 2025. 🔗 Sign up here: www.grc.org/dna-damage-m...
20.08.2025 16:30 — 👍 5 🔁 2 💬 0 📌 0
Thank you!
23.05.2025 12:59 — 👍 0 🔁 0 💬 0 📌 0
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
22.05.2025 21:30 — 👍 63 🔁 15 💬 2 📌 1
Thank you to @chowdhurylab.bsky.social (@danafarber.bsky.social) for joining us for a fantastic #WednedsayLectureSeries on "DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab. #SciSky #ResearchSky
14.05.2025 18:40 — 👍 5 🔁 3 💬 0 📌 0
A huge thank you to our speakers @kajastelab.bsky.social and Raphael Ceccaldi for their amazing talks and fascinating research at yesterday's webinar!
Our next webinar is on June 3rd featuring @agagambus.bsky.social and @chowdhurylab.bsky.social.
Join our community: docs.google.com/forms/d/e/1F...
07.05.2025 18:16 — 👍 13 🔁 3 💬 0 📌 0
We study DNA topology, the action of topoisomerses and DNA break repair to understand genome organization, dynamics and stability @cniostopcancer.bsky.social
https://repairome.bioinfo.cnio.es
A leading center for expert, compassionate cancer care and advanced research.
Appts: 877-442-3324 | http://dana-farber.org
Research Lab in the School of Molecular and Cellular Biology, University of Leeds. Focusing on all things weird and wonderful concerning SUMOylation.
Research on chromatin linked to gene regulation and genome stability. Big multisubunit complexes!
Quebec City, Canada
TheCoteLab.com
Group leader of the DDR lab at https://ipbs.fr Toulouse #CNRS. Science addict. Chemical biology and Genomics to find new druggable targets to treat #cancer & #aging. https://t.co/qZ65X6y1Qq
Studying cellular #stress responses, particularly #senescence and its impact on #immune response, #ageing and #cancer, #tumorigenesis at Cancer Research UK CI @cruk-ci.bsky.social, University of Cambridge @cam.ac.uk
Website: naritalab.com
Biologist studying blood malignancies. Coffee addict, wife, proud mother of pups and cats, foodie. UMICH PhD alumni!
#CIP2A and #Phosphatase biology for cancer therapy @TurkuBioscience @UniTurku
#PP2A #MYC #PME-1 #RAS #Breastcancer #TNBC #Epigenetics
https://bioscience.fi/research/cancer-cell-signaling
https://publons.com/researcher/3571657/jukka-westermarck/
The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own.
https://www.crick.ac.uk/research/labs/stephen-west
Our team investigates the mechanisms ensuring genome maintenance in response to DNA insults and DNA replication failures.
Scientist: durocherlab.org @ Lunenfeld-Tanenbaum Research Institute, Toronto.
Founder: Repare Therapeutics & Induxion Therapeutics
We study host-virus interactions & innate immunity in gene therapy & autoimmunity. From 🇫🇮/🇺🇦 via 🇫🇷 in 🇮🇹. Views are my own.
Dept. of Biology & Biochemistry , University of Pavia, Pavia, Italy
The Genome Integrity Italian Network is a scientific community of researchers interested in genetic information maintenance and genome stability
Geneticist and cell biologist at the University of Southern California | DNA repair | heterochromatin | recombination | nuclear dynamics | nuclear architecture | genome stability.
Dr. Brian Strahl is a chromatin researcher at UNC Chapel Hill studying how epigenetics contributes to human biology and disease. https://strahl-lab.org
Institute of Molecular Biology, BAS
#DNArepair #Replication #Genomeintegrity #Cancer #Anticancerdrugs #Microscopy
Father of 2. Group Leader at CABIMER, Seville. Studying PTM signaling by MS-based proteomics in Genome biology.
1/2 PhD Fluid dynamics, PhD in Prado Lab, Postdoc in Vertegaal Lab.
https://www.cabimer.es/en/research-groups/genome-proteomics/
IZTECH-Chemistry, I like to be Polymath(learning different subjects), Polygot(interested in the learning different languages) comments and opinions are my own RT≠ is not endorsement (he/him)
At the Stowers Institute, great minds are at work seeking to understand the function & behavior of living organisms, paving the way for future medical advances. Celebrating 25 years of discovery. #Stowers25
