The International Society for Clinical Spectroscopy

Thank you to Professor Valerie Speirs for visiting us from @uniofaberdeen.bsky.social and giving a terrific talk on "Biological Insights into Breast Cancer in Men", hosted by Dr Sacha Howell at the @mcrcnews.bsky.social with @uom-dcs.bsky.social & @cruk-mi.bsky.social
#breastcancer #research

👋 Hello Bluesky 🦋. We are the Manchester Breast Centre (MBC) – representing clinicians, scientists, technicians and students; all working collaboratively to drive research in breast biology and breast cancer.

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The Raman Map of the Human Cell

Anal. Chem. 2025
doi.org/10.1021/acs....

#ramaneffect #cells #openaccess

Spectral Region Optimization and Machine Learning-Based Nonlinear Spectral Analysis for Raman Detection of Cardiac Fibrosis Following Myocardial Infarction.
Int. J. Mol. Sci. 2025, 26(15), 7240;
doi.org/10.3390/ijms...

#ramaneffect #ml #heart #openaccess

Calculation, simulation, and experimental analysis of distorted and enhanced spectra from attenuated total reflection (ATR) This doctoral thesis extensively investigates the principles, calculations, experiments, and simulations related to the distortion spectrum and surface-enhanced spectroscopy within the framework of at...

Calculation, simulation, and experimental analysis of distorted and enhanced spectra from attenuated total reflection (ATR).

Rui Cheng, PhD thesis
University of Bremen
doi.org/10.26092/eli...

#thesis #infrared #atrir #openaccess

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope Field cancerization (FC) refers to spatially distributed premalignant tissue changes that lead to the appearance of local malignancy, and its detection can improve cancer screening. In this work, we e...

Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope.

Anal. Chem. 2025, 97, 24, 12642–12653
doi.org/10.1021/acs....

#ramaneffect #openaccess

Raman spectroscopy techniques for medical applications: analysis of human blood components.

Diagnostic Biomedical Optics
Fundamentals and applications, chapter 5
iopscience.iop.org/book/edit/97...

#chapter #ramaneffect #blood

New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy Triple-negative breast cancer (TNBC) is the most aggressive type of breast tumor with the worst prognosis. New chemotherapeutic agents against TNBC are essential, aiming at a higher efficacy regarding...

New Chemotherapeutic Approaches to Treatment of Mesenchymal Triple-Negative Breast Cancer-Sensitive and Resistant to Cisplatin: Assessment of Cellular Response by Vibrational Microspectroscopy
Anal. Chem. 2025, 97, 27, 14709–14721
doi.org/10.1021/acs....
#infrared #ramaneffect

Fourier Transform Infrared Spectroscopy (FT-IR) Diamond Attenuated Total Reflection (ATR) Measurements: The Good, the Bad, and the (Really) Ugly
Applied Spectroscopy Practica. 2025;3(2). doi.org/10.1177/2755...
#infrared #atrir #openaccess

The international society for clinical spectroscopy; reflections on the first 10 years The article provides a perspective overview of the development and current status of the field of biomedical spectroscopy, on the occasion of the tenth anniversary of the foundation of the Internation...

To celebrate our TENTH ANNIVERSARY 🎉 we have published a perspectives paper on where we've been, where we are, and where we're going...

"The international society for clinical spectroscopy; reflections on the first 10 years"

Analyst, 2025, Advance Article
doi.org/10.1039/D5AN...

Enjoy!

Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy - Acta Neuropathologica Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder marked by amyloid-β (Aβ) deposition in blood vessel walls, leading to hemorrhage and recurring stroke. Despite significant overlap with ...

Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy.
Acta Neuropathol 150, 3 (2025).
doi.org/10.1007/s004...
#optir #infrared #lipids #openaccess

YouTube video by LMF@MDIBL What are best practices for visualizing microscopy images ?

Do you follow best practices for visualizing microscopy images?

#microscopy #microscopymonday #imaging #visualization #science

youtube.com/shorts/_HlXa...

Getting ready to welcome our Summer School guests on a beautiful day in Windermere!

Monitoring the kinetic evolution of mesenchymal stem cell differentiation using Raman microspectroscopy Raman microspectroscopy (RMS) offers a powerful, non-destructive approach for in situ monitoring of dynamic biochemical processes within cells. However, the ability to reliably data-mine the spectrosc...

Monitoring the kinetic evolution of mesenchymal stem cell differentiation using Raman microspectroscopy.
Analyst, 2025, Advance Article
doi.org/10.1039/D4AN...
#ramaneffect #stemcells #openaccess

Going to SciX this year? The poster abstract deadline has extended to 14 July.
Don't miss this opportunity to contribute to SciX 2025 and share your work!
scixconference.org/abstracts

Raman spectroscopy in tandem with machine learning – based decision logic methods for characterization and detection of primary precancerous and cancerous cells Early cancer detection improves patient outcomes, but most Raman spectroscopy research has focused on discriminating between normal and malignant cells, ignoring the essential precancerous stage. This...

Raman spectroscopy in tandem with machine learning – based decision logic methods for characterization and detection of primary precancerous and cancerous cells.
Analyst, 2025, Advance Article
doi.org/10.1039/D5AN...
#ramaneffect #ml #cancer

FTIR-based machine learning for prediction of malignant transformation in oral epithelial dysplasia Oral squamous cell carcinoma (OSCC) is an aggressive cancer with a poor prognosis. Oral epithelial dysplasia (OED) is a precancerous lesion associated with an increased risk of malignant transformatio...

FTIR-based machine learning for prediction of malignant transformation in oral epithelial dysplasia.
Analyst, 2025, 150, 2809-2821
doi.org/10.1039/D5AN...
#infrared #cancer

The American Chemical Society have put together a virtual collection of papers on Liquid Biopsies.

pubs.acs.org/page/vi/liqu...
‪@pubs.acs.org‬

High-Aspect-Ratio Metal-on-Dielectric Nanostructures for Infrared Cellular Spectroscopy.
Aditya Mahalanabish. 
Cornell University ProQuest Dissertations & Theses,  2025. 31768395.
www.proquest.com/openview/5e3...
#infrared

A Novel Spectral Barcoding and Classification Approach for Complex Biological Samples Using Multiexcitation Raman Spectroscopy (MX-Raman) We report the development and application of a novel spectral barcoding approach that exploits our multiexcitation (MX) Raman spectroscopy-based methodology for improved label-free detection and class...

A Novel Spectral Barcoding and Classification Approach for Complex Biological Samples Using Multiexcitation Raman Spectroscopy (MX-Raman)
Anal. Chem. 2025, 97, 23, 12189–12197
doi.org/10.1021/acs....
#ramaneffect #openaccess

Raman spectroscopy for diagnostic tissue assessment.

Andy Cui (2025) PhD Thesis,
School of Electrical Engineering and Computer Science, The University of Queensland.
doi.org/10.14264/384...
#thesis #openaccess #ramaneffect

Two smiling staff members at an imaging facility hold up the 'Acknowledgement Guidelines' poster

Working with @globalbioimaging.bsky.social, we're very proud to launch our new #AcknowledgementGuidelines poster, helping #ImagingScientists get the credit they deserve for their research contributions! #CreditWhereItsDue

@bioimaginguk.bsky.social

Read more: rms.org.uk/resource/rms...

RamanMAE: Masked Autoencoders Enable Efficient Molecular Imaging by Learning Biologically Meaningful Spectral Representations
bioRxiv 2025.05.18.654618
doi.org/10.1101/2025...
#preprint #ramanefect #AI #openaccess

Multivariate and Machine Learning-Derived Virtual Staining and Biochemical Quantification of Cancer Cells through Raman Hyperspectral Imaging Advances in virtual staining and spatial omics have revolutionized our ability to explore cellular architecture and molecular composition with unprecedented detail. Virtual staining techniques, which ...

Multivariate and Machine Learning-Derived Virtual Staining and Biochemical Quantification of Cancer Cells through Raman Hyperspectral Imaging
Anal. Chem. 2025
doi.org/10.1021/acs....
#ramaneffect #cancer #ml

Towards a global model for Diabetic kidney disease screening using ATR-FTIR.
Microchemical Journal, available online 4 June 2025, 114193
doi.org/10.1016/j.mi...
#infrared #atrir #diabetes #kidney #renal #openaccess

Summer School (Europe) 7–11 July 2025, Lake Windermere, UK PLACES STILL AVAILABLE The International Society for Clinical Spectroscopy (CLIRSPEC) would like to invite all students, industrial colleagues and postdoctoral r…

📢Places are still available for the joint CLIRSPEC/CLIRPath-AI Summer School in July.
Book now to reserve your place!

clirspec.org/summer-school/

CLIRPath-AI have bursaries available for UK-based postdocs.

Revolutionizing prostate cancer screening: Machine learning-driven FTIR analysis of biofluidic EVs integrated with clinical profiles - Health and Technology Purpose Early detection of prostate cancer is crucial for successful treatment; however, uncertainties in prostate-specific antigen (PSA) screening often lead to invasive procedures like prostate biop...

Revolutionizing prostate cancer screening: Machine learning-driven FTIR analysis of biofluidic EVs integrated with clinical profiles.
Health Technol. 15, 563–576 (2025).
doi.org/10.1007/s125...
#infrared #prostatecancer #cancer #ml #openaccess

Evaluating the Use of Fourier Transform Raman Spectroscopy for Pollen Chemical Characterization.

Applied Spectroscopy. 2025;0(0).
doi.org/10.1177/0003...

#ramaneffect

Incidental Prompt Injections on Vision–Language Models in Real-Life Histopathology Vision–language models (VLMs) can analyze multimodal medical data. However, a significant weakness of VLMs is their susceptibility to prompt injection attacks. Here, the model receives conflicting ...

Excited to share our new publication in @ai.nejm.org „Incidental Prompt Injections on Vision-Language Models in Real-Life Histopathology“. Important work together with our amazing colleagues @janclusmann.bsky.social @jnkt.bsky.social @markuseckstein3.bsky.social et al. ai.nejm.org/stoken/defau...

AI Grand Rounds Episode 30 Rewriting the Clinical Playbook: Dr. Shiv Rao on Scaling Empathy with AI Photo of Dr. Rao

Cardiologist & Abridge CEO Shiv Rao joins NEJM AI Grand Rounds to explore what it takes to build trustworthy AI in health care. From generative #AI to clinician trust, taste to empathy — this episode is about more than tech.

🎧 Listen now: nejm.ai/ep30

#MedSky #MLSky