inflammatory

Tulku Urgyen Rinpoche Tulku Urgyen Rinpoche (1920[1] – February 13, 1996 (Tibetan: སྤྲུལ་སྐུ་ཨོ་རྒྱན་རིན་པོ་ཆེ་, Wylie: sprul-sku o-rgyan rin-po-che) (Nepali: टुल्कु उर्ग्येन् रिन्पोचे) was a Buddhist master of the Kagyü and Nyingma lineages[1] who lived at Nagi Gompa hermitage in Nepal. Urgyen Rinpoche was considered one of the greatest Dzogchen masters of his time. Born in Nangchen, Kham in Eastern Tibet[3] in 1920,[1] he was recognized by Khakyab Dorje, 15th Karmapa Lama as the reincarnation of both the Chowang Tulku and Nubchen Sangye Yeshe,[1] one of the 25 principal students of Padmasambhava. Urgyen's father was Tsangsar Chimey Dorje, a vajrayana instructor who began giving Urgyen transmission for the Kangyur, the Buddha, and "The New Treasures of Chokgyur Lingpa."[3] As he grew older, he studied Dzogchen with Samten Gyatso. He had four sons, each of whom is now an important Buddhist teacher in his own right (Chökyi Nyima Rinpoche, Tsikey Chokling Rinpoche, Tsoknyi Rinpoche and Mingyur Rinpoche); Urgyen spent 33 years at Nagi Gompa Hermitage, where he spent two decades in retreat, and eventually established six monasteries and retreat centers in Nepal. Boudhanath (Ka-Nying Shedrub Ling monastery). Another is the Tergar Osel Ling Monastery Urgyen Rinpoche died on the morning of February 13, 1996.

Tulku Urgyen (1920 - February 13, 1996)
The way to practice is not to sometimes push to recognize mind essence and then give up. It is a matter of being deeply relaxed from within, and continuing in unfabricated naturalness.
The natural state is effortless mindfulness.

Tulku Urgyen Rinpoche (1920 – February 13, 1996)
(Tibetan: སྤྲུལ་སྐུ་ཨོ་རྒྱན་རིན་པོ་ཆེ་, Wylie: sprul-sku o-rgyan rin-po-che) was a Buddhist master of the Kagyü and Nyingma lineages who lived at Nagi Gompa hermitage in Nepal. Rinpoche was considered one of the greatest Dzogchen masters of his time.

‘A great wee place’: the small Scottish factory crafting Olympic curling stones All stones in Cortina are made from granite found on tiny island in Firth of Clyde and crafted in East Ayrshire

Olympic curling stones www.theguardian.com/sport/2026/f...

The stones are made from a kind of granite that is only found on Ailsa Craig, a tiny volcanic island in the Firth of Clyde, home to an array of seabirds, and described by John Keats as a “craggy ocean pyramid” in his eponymous sonnet.

Mine is the opposite with axSpA and Psoriatic Arthritis. Did you know it takes an average of 30-60 minutes for a person with axSpA to get moving in the morning? We wake up stiff as a board and in a lot of pain. That is why movement is important. This cycle happens throughout the day and is timed around my meds. 24 hours in a day - 24 windows for your body to rebel in many different ways. Do you experience this too? ONE hour in life with chronic pain 8:00 AM - hizzuh 8:15 AM - ugh 8:30 AM - double ugh 8:45 AM - oh no 9:00 AM - flattened Credit: @chronicallymeh #Spondylitis #MySeveralWorlds

Did you know it takes an average of 30-60 minutes for a person with axSpA to get moving in the morning? We wake up stiff as a board and in a lot of pain. 24 hours in a day - 24 windows for your body to rebel. Do you experience this too?

Credit:
@chronicallymeh

#Spondylitis #MySeveralWorlds

CT abdomen/pelvis shows Ascites (red arrows), mesenteric nodularity (green arrows), and retroperitoneal lymphadenopathy (purple arrows).

top, Lymph node biopsy showing extensive granulomatous inflammation (red circles) and numerous giant cells (green arrows) on low magnification (Hematoxylin and eosin stain). bottom, Lymph node biopsy showing extensive granulomatous inflammation (red circles) and numerous giant cells (green arrows) high magnification (Hematoxylin and eosin stain).

A 54-year-old woman with rheumatoid arthritis controlled with methotrexate and adalimumab presented with subacute abdominal distension, constipation, and decreased urinary frequency. Abdominal CT showed extensive omental and mesenteric nodules, concerning for peritoneal carcinomatosis

Article from JAMA, published December 29, 2025, titled "A Woman With Rheumatoid Arthritis and Vesicular Rash." Includes photos of rash on patient's neck, ear, and hands. Possible next steps include discontinuing adalimumab or prescribing prednisone@60.

A patient receiving adalimumab for rheumatoid arthritis had ulcerated plaques on the anterior and lateral aspects of the neck, upper chest, and nape and erythroderma on the dorsum of the hands.

What is the diagnosis, and what would you do next?

ja.ma/3NOe7Kq

Description of the Painting ​The painting depicts a scene from Homer's Odyssey, specifically the moment Odysseus is welcomed at the court of the Phaeacian King Alcinous. ​Central Figure: The focal point is Odysseus, seated in the centre but turned slightly away. He is burying his face in a large, reddish brown cloak to hide his grief. His posture is hunched and clearly indicates deep emotional distress. ​The Bard: To the right of Odysseus, a rhapsode (a blind bard, likely representing Demodocus) is playing a lyre. He is in the midst of singing a song, looking upwards for inspiration. ​The Audience: Surrounding them are various courtiers and attendants. To the left, King Alcinous and Queen Arete sit on a dais, observing the scene with concern and curiosity. The other figures display a mix of attention to the music and observation of the stranger's (Odysseus's) strange reaction. ​Setting: The architecture is classical, featuring large fluted columns and drapery, setting a grand, courtly stage for this moment of vulnerability. ​ ​Schopenhauer, 1819: Viewing a painting of Odysseus sobbing finds proof of his theory that weeping is actually "noble self pity." We cry not just because we suffer, but because we perceive our own suffering from the outside 🎨😢 #Schopenhauer #Philosophy #ArtHistory #philsky artist Francesco Hayez

We cry not just because we suffer, but because we perceive our own suffering from the outside
​
​Schopenhauer 1819: Viewing a painting of Odysseus sobbing finds proof of his theory that weeping is actually "noble self pity"
🎨😢 #Schopenhauer #Philosophy #ArtHistory #philsky #artist #FrancescoHayez

YouTube video by Jackson Peterson Dzogchen: Pointing Out Rigpa

youtube.com/watch?v=gXx2...

Tulku Urgyen giving Dzogchen Pointing Out instructions

China Buddhist Association: A Trojan Horse of Chinese Propaganda Naïve Buddhists in democratic countries believe they are conducting genuine inter-Buddhist dialogue with a group that exists to advance CCP interests.

China Buddhist Association: A Trojan Horse of Chinese Propaganda bitterwinter.org/china-buddhi...

#China #Buddhist

Naïve Buddhists in democratic countries believe they are conducting genuine inter-Buddhist dialogue with a group that exists to advance #CCP interests.

‘She was a bitch in the best possible way’: the life and mysterious death of drag queen Heklina The performer was found dead in ‘unexpected’ circumstances in her London flat in 2023. Why are her loved ones still waiting for an explanation?

‘She was a bitch in the best possible way’: the life and mysterious death of #drag queen Heklina www.theguardian.com/culture/2026... the club name Trannyshack had become controversial culture evolves, words change their meaning. As a result, she changed the name of her regular show to Mother.

London Met police saw a drag queen / drugs / #LGBT ‘Lifestyle’ Death & effectively said 'case closed'. It took nearly two years to release vital CCTV footage while Heklina’s loved ones begged for answers. This is what institutional #homophobia looks like in practice. #JusticeForHeklina #Heklina

Graphic promoting the IgNS Patient Experience Survey, featuring the Immunoglobulin National Society logo, a person holding a pen while using a laptop, checklist icons overlaid on the screen, and text reading “IgNS Patient Experience Survey” and “Share Your Experience. Make an Impact.”

IgNS invites patients using Ig therapy to participate in a confidential, anonymous survey that helps inform patient education and support resources. The survey takes about 10 minutes to complete. bit.ly/4cgwl1i Thank you for taking the time to share your perspective!

As his illness progressed, Sacks found himself thinking about what constitutes a good and worthwhile life – what the Greeks would have called eudaemonia, or ‘flourishing’, rather than simply the aspects of life that render it liveable.

Are we overdiagnosing a generation with ADHD? Young people are increasingly reaching adult life with a label. A diagnosis of depression, anxiety or neurodivergence does not necessarily mean a disability, the GP and author Gavin Francis tells Dami...

www.thetimes.com/article/518f...

Oliver Sacks’s Gratitude is not a book about convalescence per se, but about the expansion of consciousness that can be offered by illness, and Sacks’s gradual reconciliation to a cancer that was slowly killing him.

Are we overdiagnosing a generation with ADHD? Young people are increasingly reaching adult life with a label. A diagnosis of depression, anxiety or neurodivergence does not necessarily mean a disability, the GP and author Gavin Francis tells Dami...

www.thetimes.com/article/518f...

And a generally hopeful outlook. “The way we think about problems of the mind changes all the time,” he says. “I draw from that, ultimately, an optimistic perspective: there’s always scope for change for the better.”

The Unfragile Mind by Gavin Francis

Top 10 most anticipated drug launches of 2026 Like last year, 2026 appears poised to herald the arrival of multiple mega-blockbusters—albeit on an even grander scale than 2025’s plenty-respectable slate of major rollouts.According to Evaluate’s…

Potential 2026 Rheumatology Drugsw/ successful phase III RCTs that will need to be reviewed by regulators:
** deucravacitinib (Sotyktu) Tyk2 inhib for PsA
** Icotrokinra (Icotyde) oral IL-23i for psoriasis
** brepocitinib TYK2/JAK1 inhibitor for dermatomyositis
www.fiercepharma.com/marketing/to...

The countdown is ON! 🕒 We are officially less than ONE WEEK away from RheumNow Live.
If Spondyloarthritis is part of your clinical world, you can't miss sessions with:
🔹 Dr. Denis Poddubnyy
🔹 Dr. Jessica Walsh
🔹 Dr. Catherine Bakewell
In Dallas or Virtual—don't miss out!
🔗 RheumNow.Live

Mandelson’s Fifth Column The British government’s business department exists to undermine democracy.

1. In 2009 I wrote this. I argued that Peter Mandelson's department “functions as a fifth column within government, working for corporations to undermine democracy and the public interest.”
This thread explains what I saw, and reaches a startling conclusion.🧵
www.monbiot.com/2009/05/04/m...

Over 860,000 Irish people are living with a #neurological condition with 50,000 newly diagnosed
each year.

Educate yourself, listen to people & join the campaigns of your local brain health organisations. Our #brain_health needs you ❤️🧠☘️

#speirgorm #spéirghorm #MS @emspofficial.bsky.social

According to a recent survey, 71% of people with a #neurologicalcondition have had to adjust their role or work schedule because of their condition, of which only 35% report that their employer was accommodating of this change. #BrainAwarenessWeek #BAW2025 #invisibleillness #neurology @efna.net

Justin Bieber while on the Grammys stage. The singer performed a sultry, slow version of his track “Yukon,” wearing nothing but his boxers and socks, and carrying his guitar

#Schopenhauer ... "Fame and youth all at the same time are too much for a mortal."
The Foundation: If a young person achieves "What One Represents" (Fame) before fully developing "What One Is" (Character/Intelligence), they are building a heavy structure on a weak foundation. #Bieber #skyphil

. . . his parts, and the sound technician would switch over to pre-recorded parts every time Mars would stray from what he was supposed to play. Mars contends the reason he can no longer perform with Mötley Crüe is ankylosing spondylitis, a type of arthritis that affects the spine and joints. . .

Description of the Painting ​The painting depicts a scene from Homer's Odyssey, specifically the moment Odysseus is welcomed at the court of the Phaeacian King Alcinous. ​Central Figure: The focal point is Odysseus, seated in the centre but turned slightly away. He is burying his face in a large, reddish brown cloak to hide his grief. His posture is hunched and clearly indicates deep emotional distress. ​The Bard: To the right of Odysseus, a rhapsode (a blind bard, likely representing Demodocus) is playing a lyre. He is in the midst of singing a song, looking upwards for inspiration. ​The Audience: Surrounding them are various courtiers and attendants. To the left, King Alcinous and Queen Arete sit on a dais, observing the scene with concern and curiosity. The other figures display a mix of attention to the music and observation of the stranger's (Odysseus's) strange reaction. ​Setting: The architecture is classical, featuring large fluted columns and drapery, setting a grand, courtly stage for this moment of vulnerability. ​ ​Schopenhauer, 1819: Viewing a painting of Odysseus sobbing finds proof of his theory that weeping is actually "noble self pity." We cry not just because we suffer, but because we perceive our own suffering from the outside 🎨😢 #Schopenhauer #Philosophy #ArtHistory #philsky artist Francesco Hayez

We cry not just because we suffer, but because we perceive our own suffering from the outside
​
​Schopenhauer 1819: Viewing a painting of Odysseus sobbing finds proof of his theory that weeping is actually "noble self pity"
🎨😢 #Schopenhauer #Philosophy #ArtHistory #philsky #artist #FrancescoHayez

Starmer apologises in China, and in return? A telling-off Xi just sees a man desperate for economic good news — the PM would sell out for a 0.1 per cent bump in GDP

After Kowtowing Starmer #China " where “everything is bugged”, where the internet is shut off, where Tibetan monks, protesters and dissenters are beaten to death, where free speech doesn’t exist, where our politicians’ mobiles are routinely tapped ... "

www.thetimes.com/article/c6d1...

The clinical and genetic information of the patient with OGFRL1 mutation. (A) Imaging manifestations of the patient, uneven flattening of the C3, C6, and C7 vertebral bodies, deformed, malpositioned, and displaced posteroinferiorly C6-C7 disc, compressing the thecal sac (Left image); Multiple patchy T1 hypointense/T2-FS hyperintense lesions in bilateral iliac bones (para-articular), pubic bones, S1–S2, and right proximal femur, some with marginal T2 hypointensity, and bilateral sacroilitis with irregular joint spaces (Middle image); Multiple patchy irregular T2 hyperintense signals in right distal femoral and proximal tibial metaphyses (Right image). (B) Clinical improvement with TNF inhibitor therapy. Pre_treatment: The imaging manifestations of the patient before the regular treatment of adalimumab. [...] Post_treatment: The imaging manifestations of the patient after the administration of adalimumab according to the lesions above.

Seq study of a patient with chronic recurrent multifocal osteomyelitis identified OGFRL1 deficiency as genetic cause, with a subsequent mouse model suggesting pathogenesis by promoting osteoclastogenesis. TNFi therapy led to clinical improvement

Arthritis & Rheumatology
doi.org/10.1002/art....

Effectiveness of Abatacept vs Adalimumab in HLA-DRB1 Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis

Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation

January 2026 Arthritis & Rheumatology Clinical Connections:

• Effectiveness of Abatacept vs Adalimumab in HLA-DRB1 Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis
• Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation

acr.tw/3Z2UvEP

What is in the Epstein files? The key revelations so far Andrew Mountbatten-Windsor, Lord Mandelson, Donald Trump, Elon Musk, Richard Branson and Bill Gates are mentioned in the tranche of three million documents

Reinaldo Avila da Silva, who has been in a relationship w Labour peer #Mandelson since the 1990s and married him in 2023, appears to have emailed #Epstein in September 2009, after the financier was jailed for soliciting sex with minors for £10000

www.thetimes.com/article/1776...

Andrew pictured in Epstein files ‘crouched over woman’ New photos of Mountbatten-Windsor and an invitation for the disgraced financier to visit Buckingham Palace are in the three million newly released files

#royal Andrew, a UK trade ambassador #Epstein later lying to Newsnight it was to break off the friendship — wrote 2 Epstein outlining a business opportunity in Afghanistan shared a “confidential brief” about “Afghanistan International ­business opportunities”.

www.thetimes.com/article/641a...

2026 SPARTAN Annual Meeting (May 14-16; Toronto) is now accepting abstract submissions! A premier mtg brings together cutting-edge researchers and teachers in spondyloarthritis (SpA). Submit your abstracts by Feb 1st!! spartangroup.org/2026-call-fo...

Nana's Recipe for Fruit Cake XMAS CAKE 8 ounces of Butter. 8 ounces of Sugar. 10 ounces of Plain Flour. 4 Eggs. 4 ounces of Ground Almonds. 2 ounces of Cherries. 3 ounces of Chopped Almonds. 8 ounces of Raisins. 8 ounces of Sultanas. 8 ounces of Currants. 1 Level Teaspoon of Mace. 1 Level Teaspoon of Nutmeg. Bake on Number 1 for three and a half hours.

Nana's Recipe for Fruit Cake
www.theguardian.com/food/2026/ja... @theguardian.com
#XMASCAKE