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Ahamed PK

@ahamedpk.bsky.social

Erika Gyengesi Lab, WSU IISc graduate, 2024 Cholinergic system | Neuroinflammation | Neuroscience

18 Followers  |  100 Following  |  3 Posts  |  Joined: 06.09.2024  |  1.3927

Latest posts by ahamedpk.bsky.social on Bluesky

Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease https://www.medrxiv.org/content/10.1101/2025.08.10.25333397v1

13.08.2025 00:26 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Many recent studies associate Bassoon with neurological diseases. Case reports and genetic studies link Bassoon variants to disorders like epilepsy, PSP, and PD.
However, the mechanistic understanding of Bassoon's role in pathology is in its infancy.

28.03.2025 03:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

The major function of the scaffolding protein Bassoon is in enabling high frequency neurotransmitter release through synaptic vesicle reloading. Bassoon is also involved in the transport of presynaptic proteins to the bouton and in maintaining proteostasis.

28.03.2025 03:04 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Bassoon, Presynaptic Scaffolding Protein: Narrative Review in Health and Disease Presynaptic Scaffolding Protein: Bassoon. The graphical abstract visually summarizes the role of Bassoon (BSN), a presynaptic scaffolding protein, in both normal physiological functions and disease s....

I invite you all to read our recent review article on the presynaptic protein Bassoon. The article addresses a crucial topic, the involvement of Bassoon in neurological diseases and the lack of mechanistic information thereof.
#bassoon #BSN #Disease

onlinelibrary.wiley.com/doi/10.1111/...

28.03.2025 03:01 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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