Joel Miesfeld

New preprints from the lab (3)! www.biorxiv.org/content/10.1...

New preprints from the lab!! (2)

Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development The Sonic Hedgehog (Shh) signaling pathway is essential for the patterning, growth, and morphogenesis of many tissues. During early eye development, Shh is critical for the formation of the two optic ...

🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...

Preventing Blindness by Untangling the Genetic Network of Vision Neurons Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.

Damaged retinal ganglion cells can lead to blindness. MCW’s Dr. Joel Miesfeld is conducting #research into the development of these cells to better identify ways to help them regenerate after damage. Learn more: www.mcw.edu/mcwknowledge...

#Ophthalmology #VisionHealth #MCWKnowledge

Preventing Blindness by Untangling the Genetic Network of Vision Neurons Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.

A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...

Check out this 40x confocal image of a transgenic zebrafish eye showing UV (red) and blue cones (green), key for color vision. Zebrafish use UV vision for prey detection and navigation!

Got interesting data or images? Send your science with a brief description to be featured!

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

🎉 MCW grad students: come to the GSA Welcome Social on Aug 22, 5–8 PM at Hoyt Park!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!

Should have included these two co-organizers in the original post @icanhasmiranda.bsky.social @aoiplab.bsky.social

Morning view during jog in Madison

Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers

🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing

Tom Still: Cancer tests continue to propel Exact Sciences, even in time of research cuts Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.

Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.

Meet your 2025–26 GSA Officers & Reps! 👋
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊

DaniocellDesktop logo, depicting a fish on a laptop screen.

If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)

Congratulations!

“Our results suggest that some axons regenerate along tracts of degenerating myelin debris. However, the topography of re-innervation is different after regeneration, suggesting that new axon tracts are created to restore functional vision.”

New work from @pennylamphd.bsky.social et al. 🐠

See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1

Not sure where the updated form would be located and if it’s different. This was done by our grants administrator but this is the method we used to list the study section preference.

I submitted mine through an assignment request form and not the cover letter. grants.nih.gov/grants/how-t... Same information is stated in the cover letter information, which is not always allowed. grants.nih.gov/grants/how-t... I hope this helps.

Development's 2024 outstanding paper prize We introduced our Outstanding Paper Prize in 2022 (Briscoe et al., 2023). Each year since then, reviewing the papers shortlisted by our editors, and selecting the finalists and overall winner has beco...

Dr. Kevin Emmerich, my former graduate student, will be presenting a summary of his thesis work as a finalist for the 2024 Outstanding Paper Prize from Development. Webinar is next Wednesday, May 28th:

journals.biologists.com/dev/article/...

Nintendo Switch Sonic Olympics game up on a projector screen with 10 people watching and

Nintendo Switch Mario Kart on a projector screen with 6 people watching and playing

“Vision Science Team Building” not pictured: Just Dance competition

@joelmiesfeld.bsky.social

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment NIH-supported gene-editing platform lays groundwork to rapidly develop treatments for other rare genetic diseases.

www.nih.gov/news-events/...

Stop by A0265 today and say hi to @minagaffney.bsky.social - she’s sharing results from our AO corrected visual acuity project, made possible by a collaboration with @roordalab.bsky.social and Will Tuten.

A huge congratulations to Alex Gallo for a fantastic poster presentation today at #ARVO2025 !

Emily Woodruff giving her talk at #ARVO2025

So thrilled for Emily Woodruff, who just crushed her talk at #ARVO2025

@ismaelhdeznunez.bsky.social just gave a brilliant talk at #ARVO2025

The Retinal Development session at #ARVO2025 is just gorgeous. Adam Almeida gave a truly fantastic talk! 🤩

Come check out Hannah’s @arvoinfo.bsky.social poster (B500) at 3:15pm-retinal structure in Tyr gene edited 13-lined ground squirrels. #ARVO2025

Come check out Megan’s @arvoinfo.bsky.social poster (A128) at 3:15pm-iORG based measures of cone function in patients with early retinal pathology. #ARVO2025