Andreas Horn

Make America Numerate Again

The massive list of suspended UCLA grants came out today: 300 NSF and 500 NIH grants. I am miraculously not on the list, but this is devastating. Science will be lost, progress will be frozen, people will lose jobs, and careers in science and medicine are being destroyed. This is not ok.

Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?

Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

Work by Tara Arbab, Ingo Willuhn et al. on neural biomarkers in OCD was published in Nature Mental Health.🗨️Arbab about the study: "It's unique that we were able to measure deep brain activity with very high spatial and temporal precision.” @willuhnlab.bsky.social www.amsterdamumc.org/en/research/...

Glad to see this one out - massive effort by Aaron Warren and @rolstonjohn.bsky.social - and a major milestone toward treating disorders of consciousness with DBS!
👇👇

A king that doesn’t tolerate a good court jester isn’t a real king.

More on the Action Mode Network!

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...

on the same notion but here we see an expansion of that idea.

In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.

onlinelibrary.wiley.com/doi/10.1002/...

Work from @andreashorn.org and colleagues.

New paper in Imaging Neuroscience by Christopher Güttler, Anna Tietze, et al:

Toward a standard preoperative MRI protocol for functional neurosurgery

doi.org/10.1162/IMAG...

In @ohbmossig.bsky.social's first Open Datasets Special Issue paper, Wearn et al. introduce the OHBM Time Machine, a freely accessible archive of Annual Meeting content on YouTube: doi.org/10.52294/001...

@alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social @stephforkel.bsky.social

This was such a great and inspiring talk. So great to see a clear demonstration of what animal imaging can tell us about the human condition.

Interesting difference in the S&P when looking at it in USD vs in Euro. In USD it’s on an all time high, when expressed in Euro it never recovered after the tariffs (since the USD tanked).

Cool thread! The agranular PFC does a lot of things, it’s one of the oldest cortical regions. Naturally also pain processing and movement. AMN is a good handle on it when using fMRI and as such is involved in diverse functions - cool stim data as well (even if N=2) 👇👇

Excited to be shipping pieces, including this one, to a wonderful collection in NYC.

Beautifully framed behind museum glass.

#sciart #printmaking

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Second time I’ve gotten a clearly ChatGPT generated review on a manuscript

I am privileged to announce the publication of the Anti-Autocracy Handbook: sks.to/autocracy 1/12

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!

lnkd.in/eEbnXByJ

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....

@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

We’ve been implanting electrodes into human brains since the 1950ies - its not Sci-Fi anymore but routine, leads to improved quality of life and …actually works pretty marvelously in man cases.

Who in my circle still remembers the macOS classic RAM Disk?

two men are sitting next to each other and one of them is saying teamwork ALT: two men are sitting next to each other and one of them is saying teamwork

Let me use this opportunity to thank all the dear (and very busy) surgical colleagues for their help in this manuscript, as well as Chris & Anna for the main effort & for seeing this through!! Study here: direct.mit.edu/imag/article...

Toward a standard preoperative MRI protocol for functional neurosurgery Hosted on the Open Science Framework

…with the same concept that may compare the winning sequences with even better sequences that somebody on the globe may have. If you think your sequence is better than the one we provide, please do contact us! Sequence as PDF & EXAR, niftis and dicoms available here: osf.io/p63zf/wiki/h...

As a result, we provide an 'optimal' sequence for preop DBS using the best-rated sequences. We hope that this could be a first step toward standardizing DBS imaging across the globe. Of course, this is a first draft – we hope to incrementally increase quality going forward using follow up studies …

Chris also compared surgical ratings with automated (MRIqc) signal to noise estimates. While these correlated significantly, the automated assessment did not correlate with better targeting homogeneity across surgeons (but surgical ratings did).

These are all the sequences that were tested – it was a lot! Sequences were randomly presented to surgeons to avoid tiring / sequentiality effects while rating.

When comparing all the T2 sequences, more scan time was not automatically better – which is great, since movement disorders patients may sometimes have more head motion than healthy controls.