Chhabi Govind, PhD

Gov shutdown notice from IAR eRA commons

Well this is deliciously imprecise. IAR notice in NIH’s eRA Commons. Since they know who is and is not a gov employee, they could omit this for peer reviewers if they didn’t mean us. I’m pretty sure they don’t mean non-gov but WHO KNOWS!?!?!

Autophagy UK Network Visit the post for more.

UK Autophagy members please have a look at website-we will be updating regularly with meeting information
autophagyuk389582434.wordpress.com

Fig 1. System overview of FLIM Playground. After (A) loading a saved configuration, (B) Data Extraction collects and validates channel inputs across all fields of views, (C) calibrates for IRF shifts or uses reference standards, and (D) extracts single-cell lifetime (fitting and phasor), morphology, and texture features in one step. (E) To bridge the data extraction with downstream analysis, FLIM Playground combines multiple single-cell datasets and assists users with assigning category labels to each cell. (F) The three feature classes include identifiers (red), numerical features (yellow), and categorical features (blue), are transformed into interactive widgets shared by all analysis methods. (G) Data Analysis includes univariate, bivariate, and multivariate modules. (H) FLIM Playground can either be deployed online in major operating systems or as a data analysis web application. Interactive interfaces are indicated by green backgrounds.

FLIM Playground: An interactive, end-to-end graphical user interface for analyzing single-cell fluorescence lifetime data by Rupsa Datta and team: www.biorxiv.org/content/10.1...

Autophagy: Mechanisms to Therapy | Keystone Symposia Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!

Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

🧠 Alzheimer’s reversed in mice

A new study found that injecting nanoparticles can 'remind' the blood–brain barrier to function properly again, restoring normal brain activity in mice. Human trials could follow within years.

🔗 www.nature.com/articles/s41...

#SciComm #Alzheimers 🧪

If you are a computational biologist interested in how chromatin states are established and maintained to regulate transcription, this is the dream job for you! This will be in close collaboration with the Klose lab in Oxford and we have a lot of cool projects you can get involved in. Apply!

Cartoon from the Nobel Assembly showing the three prize winners, their names, and “for their discoveries concerning peripheral immune tolerance.”

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Sorry extramural scientists, this is not a vacation day.

Lysosomes signal through the epigenome to regulate longevity across generations The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

Metabolism changes the epigenome across generations via lysosome Supercool! www.science.org/doi/10.1126/...

Multiple people shot at Mormon church in Michigan and shooter is down, police say Police say multiple people have been shot at a Mormon church in Michigan and the shooter is down. Local police said in a social media post that the shooting occurred at the Church of Jesus Christ of Latter-day Saints in Grand Blanc, about 50 miles north of Detroit.

BREAKING: Multiple people have been shot at a Mormon church in Michigan and the shooter is down, police say.

Nucleosome phasing by chromatin remodelers regulates macrophage lineage fidelity by preserving nucleosome arrays flanking PU.1-bound sites to prevent lineage-inappropriate transcription by C/EBPβ @cp-immunity.bsky.social www.cell.com/immunity/ful...

I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...

Histone Acetyltransferases Gcn5 and Esa1 Regulate Occupancy of RSC to Maintain Nucleosome-Depleted Regions and Promote RSC Recruitment to Coding Regions Genome-Wide in Saccharomyces cerevisiae Chromatin remodelers are important for maintaining chromatin structure and regulating gene expression. In this study, we investigated the roles of histone acetyltransferases (HATs) Gcn5 and Esa1 in...

Very nice!
doi.org/10.1080/1098...

Comparative analysis of two autophagy-enhancing small molecules (AUTEN-67 and -99) in a Drosophila model of Spinocerebellar ataxia type 1 https://www.biorxiv.org/content/10.1101/2025.09.18.677017v1

Or smaller entities

Thank you!!

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

Yes, she is!

My lab at The Wistar Institute is recruiting on multiple levels!

We are looking for a research technician and/or senior lab manager to help support all lab projects. Cell culture, molecular biology, and animal handling expertise and 3+ years of experience needed. Apply here: lnkd.in/ecvdTwkf

Structural basis for mTORC1 activation on the lysosomal membrane - Nature Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

Version of Record
Structural basis for mTORC1 activation on the lysosomal membrane
www.nature.com/articles/s41...

Histone Acetyltransferases Gcn5 and Esa1 Regulate Occupancy of RSC to Maintain Nucleosome-Depleted Regions and Promote RSC Recruitment to Coding Regions Genome-Wide in Saccharomyces cerevisiae - PubMe... Chromatin remodelers are important for maintaining chromatin structure and regulating gene expression. In this study, we investigated the roles of histone acetyltransferases (HATs) Gcn5 and Esa1 in re...

pubmed.ncbi.nlm.nih.gov/40958614/

Thank you.

I know they can fund the previously scored grant but not sure the time gap that makes it ineligible for funding.

Is it allowed to fund high scoring grants past the fiscal year?

Chromatin landscape of budding yeast acquiring H3K9 methylation and its reader molecule HP1 Histone H3 lysine 9 (H3K9) methylation and heterochromatin protein 1 (HP1) are well conserved heterochromatin epigenome and its reader molecule. However, the details of how importance of them in heter...

Fascinating: giving yeast H3K9 methylation to see what happens

Chromatin landscape of budding yeast acquiring H3K9 methylation and its reader molecule HP1

www.biorxiv.org/content/10.1...

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

A bluetorial on NIH funding and out year commitments:

A historical perspective

RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction https://www.biorxiv.org/content/10.1101/2025.09.11.675598v1