Jackson Hoffman

Updated job posting description for our postdoc recruitment to include interest in immuno-oncology

Interested in transcriptional regulation, enhancers and 3D genome folding?

In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control

www.biorxiv.org/content/10.6...

detailed 🧵👇

Tomorrow!

Two exciting talks on tap from @ambystoma22.bsky.social and @epijenatics.bsky.social at @fnucleosome.bsky.social seminar!

We've got two exciting chromatin talks coming up on Wednesday next week:

@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!

register and join us: us06web.zoom.us/webinar/regi...

DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

Final version of our paper now published.
elifesciences.org/articles/109...

Take homes:
CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

Hi everyone!
The talk I had the chance to give with @fnucleosome.bsky.social last October is now out on Youtube!
If you like evolution, 3D genomics, biodiversity and/or fungi, I think you might like it! 🧬🧪🍄
The submission of this paper has never been that close!

www.youtube.com/watch?v=Plez...

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity Milovanović et al. uncover a mechanism by which KZFPs restrict the activity of transposon-derived cis-regulatory elements to safeguard cardiomyocyte functionality. This work extends the classical TE-K...

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports....
Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

#FragileNuclesome is back tomorrow! Join us to hear about exciting talks from:

- @au-ho-yu.bsky.social in @robklose.bsky.social's group about transcriptional control by SET1/MLL complexes

- @gcloner.bsky.social at @epicypher.bsky.social about the histone PTM landscape of the immune system

Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social

🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...

The Vlaming lab continues to grow!
It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!

a man wearing a plaid shirt and a purple hat is saying here we go . ALT: a man wearing a plaid shirt and a purple hat is saying here we go .

Our paper on the Expanded Registry of candidate cis-Regulatory Elements (cCREs) is out 🎉
www.nature.com/articles/s41...

To celebrate, here’s a "meme-torial" walkthrough of the science.

Let’s get started 🧵 1/11

Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...

Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!

We just posted a new preprint from the @dphansti.bsky.social 👇

Preprint: www.biorxiv.org/content/10.6...

🧵

Today! Join us for the last Fragile Nucleosome talks of 2025!

Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones)

But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :

www.biorxiv.org/content/10.6...

Very happy with the final version of this work showing menin-MLL is a vulnerability in liver cancer and an interesting re-localization of NF-Y in response to menin inhibition. Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival: Cell Reports doi.org/10.1016/j.ce...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?

Yes, one can. with CUT&ID ✂️🪪

Spearheaded — singlehandedly — by @annanordin.bsky.social

No need of transgenesis, cloning and overexpression.

Check it out, it's fast and its works.

Very excited to share our work on locus level transposable elements in development with the @fnucleosome.bsky.social community!

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...

I am hiring a postdoc (or two!) to work on C. elegans reproductive system development. Our MIRA funds work on cell size, migration, and niche signaling. Our CAREER funds work on regulation of gonad growth, degrowth, and regeneration during and after starvation

unc.peopleadmin.com/postings/310...

Starting in 90 minutes!!!

does #23 imply that human babies are model organisms?

🔔Join us next Wednesday for #FragileNucleosome! 2 fantastic talks on chromatin regulation:🔬 @mariamafau.bsky.social on ZIC2's dual role in neural induction 🔬 @jhenninger.bsky.social on how RNA-binding proteins drive transcription
📋Register here for the entire series: us06web.zoom.us/webinar/regi...

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

now revised and journal accepted at www.science.org/doi/10.1126/...

🧵👇

👍

Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?

Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!

👉 www.molgen.mpg.de/5094682/Fuey...

Join us next week to hear about:
* @mariamafau.bsky.social's awesome graduate work
* the exciting work in @jhenninger.bsky.social's new lab