Laura

"...by the time we enter the workforce, we rarely pause to ask whether we are living according to our own values or those imposed upon us"

Thank you @frezzalab.bsky.social to always give voice to common thoughts in our (and not only) professional field.

An atlas of ferroptosis-induced secretomes Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social

rdcu.be/ejp9C

Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism Nature Cell Biology - Kim et al. show that NAD+ kinase 2 serves as a source of mitochondrial NADPH to support mitochondrial fatty acid synthesis, protein lipoylation and mitochondrial oxidative...

www.nature.com/articles/s41...

MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling Rigoni et al. use complexomic to develop two online-available tools, MARIGOLD and MitoCIAO, mapping mitochondrial protein interactions during membrane remodeling. MARIGOLD provides “digital western bl...

MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling: Cell Metabolism www.cell.com/cell-metabol...

Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA Organelle network is regulated to prevent cellular inflammation.

Excess mitochondrial fusion is averted by stress-activated regulators, preventing the potentially harmful release of mitochondrial DNA
https://go.nature.com/3EGN5QL

Rhodoquinone carries electrons in the mammalian electron transport chain Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis
www.biorxiv.org/content/10.1...

Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.

www.nature.com/articles/s41...