Cristina Muñoz Pinedo's Avatar

Cristina Muñoz Pinedo

@crismunozp.bsky.social

Scientist by day, defender of lost causes by night. Especially the right to not spend our lives filling online forms. Cell death, Cancer metabolism, Metabolic stress, ISR/UPR, mesothelioma and lung cancer

696 Followers  |  402 Following  |  67 Posts  |  Joined: 09.12.2023  |  1.9288

Latest posts by crismunozp.bsky.social on Bluesky

Interesting :-D

17.07.2025 15:44 — 👍 1    🔁 0    💬 0    📌 0
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happy birthday ... to me :-)

17.07.2025 10:37 — 👍 1    🔁 0    💬 0    📌 0
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She:
Hey! What have you been up to? Have seen you in years!

Me:
Supplementary figure 5, A-Z

09.07.2025 19:36 — 👍 9    🔁 0    💬 0    📌 0
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An unexpected career in cancer metabolism Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I

08.07.2025 14:20 — 👍 64    🔁 14    💬 2    📌 3

🤦‍♀️ so sorry

08.07.2025 20:27 — 👍 0    🔁 0    💬 0    📌 0
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MetaboList – June 2025 Cystine / Glutathione SLC7A11 is an unconventional H+ transporter in lysosomes Nan Zhou, Jingzhi Chen, Meiqin Hu, Na Wen, Weijie Cai, Ping Li, Liding Zhao, Yaping Meng, Dongdong Zhao, Xiaotong Yang…

Interesting articles on cancer metabolism - and ocassionally, just metabolism- published last month
metabolist.wordpress.com/2025/07/03/m...

03.07.2025 15:18 — 👍 3    🔁 1    💬 0    📌 0
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ApoList – June 2025 Bcl-2 family proteins Structural basis of BAX pore formation Ying Zhang, Lu Tian, Gaoxingyu Huang, Xiaofei Ge, Fang Kong, Pengqi Wang, Yige Xu, and Yigong Shi. BH3 mimetics targeting BCL-XL have ef…

Interested in cell death?
Here's a few interesting papers published last month
celldeath.wordpress.com/2025/07/03/a...

03.07.2025 15:10 — 👍 3    🔁 1    💬 0    📌 0

“84% believe climate change is caused by human activity”
Well… the 16% left are very loud!

01.07.2025 22:01 — 👍 2    🔁 0    💬 1    📌 0
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Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer @natimmunol.nature.com @ddimitrilab.bsky.social www.nature.com/articles/s41...

01.07.2025 16:12 — 👍 8    🔁 5    💬 0    📌 0
Inflammasome and infection

We are looking for a new editor for a report on #inflammasome and #infection. You would screen a ranked list of abstracts on this topic. Take a look at the report so far, it has been active for almost 2 years. Let us know if you are interested or have any questions biomed.news/bims-inflin

26.06.2025 08:00 — 👍 2    🔁 6    💬 0    📌 0
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SLC7A11 is an unconventional H+ transporter in lysosomes SLC7A11 acts as an unconventional proton exporter in lysosomes regulating proteolytic degradation, ferroptotic cell death, and Parkinson’s disease pathology.

Awch! So many weak/weird results about metabolism and funny forms of cell death published in high impact journals … probably wrong

SLC7A11 is an unconventional H+ transporter in lysosomes: Cell www.cell.com/cell/fulltex...

27.06.2025 10:23 — 👍 1    🔁 1    💬 1    📌 0
The Most Beautiful Experiment: Meselson and Stahl
YouTube video by Science Communication Lab The Most Beautiful Experiment: Meselson and Stahl

Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...

26.06.2025 10:01 — 👍 138    🔁 72    💬 5    📌 7
Autosis: a new addition to the cell death tower of babel - Cell Death & Disease Cell Death & Disease - Autosis: a new addition to the cell death tower of babel

My two cents:
“Coining a new term for a subtype of cell death that clearly fits into an existing category is unwarranted and contributes to creating a scientific tower of Babel where it becomes progressively difficult to know what we are all talking about.”

25.06.2025 21:41 — 👍 3    🔁 0    💬 0    📌 0
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E.P.A. Plans to Reconsider a Ban on Cancer-Causing Asbestos

E.P.A. Plans to Reconsider a Ban on Cancer-Causing Asbestos ¯\_(ツ)_/¯ www.nytimes.com/2025/06/16/u...

17.06.2025 00:55 — 👍 1125    🔁 464    💬 229    📌 498
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NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment Activation under hypoxia boosts immunogenic properties of macrophages with protective potential in cancer.

Esteban Ballestar’s lab studied LPS-driven activation under hypoxia here. They’re more inflammatory, contrary to what was thought
www.science.org/doi/10.1126/...

07.06.2025 13:38 — 👍 3    🔁 0    💬 0    📌 0
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MetaboList – May 2025 Glucose and sugars Glycogen drives tumour initiation and progression in lung adenocarcinoma Harrison A. Clarke, Tara R. Hawkinson, Cameron J. Shedlock, Terrymar Medina, Roberto A. Ribas, Lei Wu, Zi…

Many cool articles in the Metabolist this month.
metabolist.wordpress.com/2025/06/03/m...

03.06.2025 16:56 — 👍 2    🔁 2    💬 0    📌 0
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Let's review I Good morning, bonjour, buongiorno, guten morgen, dzien dobry, maj po! (Sorry if I left out your language, but I did get you if you are Klingon. In any case, hi there!). It is a bea-u-ti-ful spring day...

PEER REVIEW by Mole
... So when the power falls to us, we (and by ‘we’ I mean ‘some of us’) unleash our pent up frustrations. This is not idle speculation, this explanation for what seems to be widespread grumpiness in the peer review process. journals.biologists.com/jcs/article/...

02.06.2025 16:13 — 👍 0    🔁 0    💬 0    📌 0
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ApoList – May 2025 Bcl-2 family proteins Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies Julie A. MacDonald, Gary A. Bradshaw, Fleur Jochems, René Be…

Interesting articles about cell death, May 2025
Caspases, ferroptosis, necroptosis, pyroptosis, lysis, death receptors ...
celldeath.wordpress.com/2025/06/02/a...

02.06.2025 16:01 — 👍 1    🔁 1    💬 0    📌 0
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I Fooled Millions Into Thinking Chocolate Helps Weight Loss. Here's How. “Slim by Chocolate!” the headlines blared. A team of German researchers had found that people on a low-carb diet lost weight 10 percent faster if they ate

"Onneken and Löbl had everything lined up: a few thousand Euros to recruit research subjects, a German doctor to run the study, and a statistician friend to massage the data."
(via The Browser)

gizmodo.com/i-fooled-mil...

31.05.2025 12:28 — 👍 1    🔁 2    💬 0    📌 0
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ApoList – April 2025 Bcl-2 family proteins Structural basis of BAK sequestration by MCL-1 in apoptosis Shagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, …

ApoList – April 2025 – Articles on apoptosis and cell death
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...

06.05.2025 13:41 — 👍 2    🔁 1    💬 0    📌 0
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MetaboList – April 2025 Glucose and sugars High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients Ling Cai, Nia G. Hammond, Alpaslan Tasdogan, Massar Alsamraae, Chendo…

Papers on cancer metabolism - April 2025

Metabolism of glucose and other sugars, amino acids, lipids, starvation responses and nutrient sensing, immunometabolism of cancer, cachexia ...

MetaboList
metabolist.wordpress.com/2025/05/06/m...

06.05.2025 12:50 — 👍 4    🔁 1    💬 0    📌 0
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@crismunozp.bsky.social it was awesome to work with you and Mabel on that.. really enjoyed it and I love the result...
Sometimes we should really listen to the reviewers :o)))) they have great questions (and ideas) ---- doi.org/10.1111/febs...

24.04.2025 18:57 — 👍 2    🔁 1    💬 0    📌 0
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FEBS Press The unfolded protein response (UPR) is engaged by perturbations of protein folding in the endoplasmic reticulum (ER). Here, we compile evidence that the UPR is activated by physiological and patholog...

A reviewer asked: but why is IRE1 activated when glucose is low?
A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation?
So we wrote a review about it.
Here it is!
@ericchevet.bsky.social @febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...

24.04.2025 18:20 — 👍 24    🔁 13    💬 2    📌 0
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Dejo esto por aquí 😉

19.04.2025 15:27 — 👍 1    🔁 1    💬 0    📌 0
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Efficacy and safety of bintrafusp alfa evaluated in a phase II single-arm clinical trial in previously treated advanced pleural mesothelioma We aimed to evaluate the efficacy (progression-free survival [PFS]) of bintrafusp alfa in patients with pleural mesothelioma (PM) who had progressed t…

Our work led by Ernest Nadal's clinical team, who tested immunotherapy in pleural #mesothelioma
www.sciencedirect.com/science/arti...

18.04.2025 16:23 — 👍 1    🔁 0    💬 0    📌 0
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Top researcher quits NIH, citing censorship under RFK Jr. | CNN Dr. Kevin Hall joins The Lead

Thanks to @jaketapper.bsky.social for inviting me on his show yesterday! www.cnn.com/2025/04/17/h...

18.04.2025 11:50 — 👍 837    🔁 247    💬 16    📌 9

Por otro lado: "Por fuera parecía un cabrón, pero si se miraba más a fondo, por dentro, todavía se veía a un cabrón”.

13.04.2025 07:47 — 👍 0    🔁 1    💬 0    📌 0

C'mon guys,
don't notify grant rejections on Friday afternoon!

11.04.2025 13:52 — 👍 3    🔁 1    💬 0    📌 0

American friends:
you'll find that a lot of Governments in Europe are launching programs to "attract American talent" with huge press fanfare.

Don't fall for it. Ask the locals. Do your research. There is no core funding in most of Europe, and institutional grant calls are sometimes random.

02.04.2025 12:07 — 👍 2    🔁 0    💬 0    📌 0

This one hurts a lot. Richard is a great scientist. His elegant work inspired me to get into mitochondrial biology and he went out of his way to help me establish myself in the field. So sad for our whole community.

02.04.2025 01:51 — 👍 126    🔁 32    💬 7    📌 1

@crismunozp is following 20 prominent accounts