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Steve Saklad

@saklad.name.bsky.social

Clin Prof Emeritus at UT Austin, Col of Pharm, Div of PTherapy & Trans Sci, based in San Antonio. PharmD, BCPP, AAPP, clin care, CNS disorders & treatment, consultant for clin care & research, tech, space, equality, diversity, climate, & civility.

337 Followers  |  310 Following  |  998 Posts  |  Joined: 24.08.2023  |  1.8304

Latest posts by saklad.name on Bluesky

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One major rule anchored U.S. climate policy. The EPA just threw it out The Trump administration rescinded the 2009 β€œendangerment finding,” ending regulation of greenhouse gases from cars and trucks

Well, who really benefited from a cleaner environment anyway? www.scientificamerican.com/article/epa-...

12.02.2026 21:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Figure 1: Effect of statin versus placebo on events listed in statin SmPCs, subdivided by component parts
Results for two outcomes with fewer than ten events are not shown in the figure, but are included in the appendix. FDR=false discovery rate. LFT=liver function test. RBC=red blood cell. RR=rate ratio.
SmPC=Summary of Product Characteristics. *FDR significant at the 5% level; RR for results FDR-significant at the 5% level are indicated by black circles and RR for results not FDR-significant at the
5% level indicated by grey circles. †Excluded from FDR testing; RR for results excluded from FDR testing indicated by white circles.

Figure 1: Effect of statin versus placebo on events listed in statin SmPCs, subdivided by component parts Results for two outcomes with fewer than ten events are not shown in the figure, but are included in the appendix. FDR=false discovery rate. LFT=liver function test. RBC=red blood cell. RR=rate ratio. SmPC=Summary of Product Characteristics. *FDR significant at the 5% level; RR for results FDR-significant at the 5% level are indicated by black circles and RR for results not FDR-significant at the 5% level indicated by grey circles. †Excluded from FDR testing; RR for results excluded from FDR testing indicated by white circles.

Meta-analysis of 19 DB R trials (N=123,940) comparing statin to placebo revealed that besides the well known effects on muscle outcomes and diabetes, only 4/66 (6%) of listed AEs that had been attributed to statins were found to be significant. #Medsky www.thelancet.com/action/showP...

12.02.2026 21:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Prasad overruled FDA staff to reject Moderna's flu vaccine application The rejection is the latest instance of Vinay Prasad overruling career FDA scientists to place vaccines under harsher scrutiny.

Scoop: Top FDA official Vinay Prasad overruled the agency’s reviewers when he refused to accept Moderna’s application for a new influenza vaccine, STAT has learned.
www.statnews.com/2026/02/11/m...

11.02.2026 15:34 β€” πŸ‘ 412    πŸ” 256    πŸ’¬ 22    πŸ“Œ 34
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Live updates: Trump's EPA revokes scientific finding that underpinned US fight against climate change The Trump administration revoked a scientific finding at the center of U.S. action to regulate greenhouse gas emissions and fight climate change, a significant rollback of regulations.

BREAKING: The EPA revokes scientific finding that greenhouse gases endanger the public health, removing a key basis for the climate change fight.

12.02.2026 18:54 β€” πŸ‘ 630    πŸ” 327    πŸ’¬ 221    πŸ“Œ 407
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All the Ways Moderna’s Flu Vaccine Rejection Letter Shocked Us The FDA issued a rare Refusal-to-File letter to Moderna over its mRNA-based influenza vaccine application, in an unusual move that sent the biotech’s shares tumbling.

1. Refusal to File (RTF) determinations are rare and previously reserved for incomplete applications
2. CBER Head Vinay Prasad Personally Signed the Letter
3. Moderna Published the Letter Itself
4. Moderna CEO StΓ©phane Bancel Responds Publicly
#Medsky www.biospace.com/fda/all-the-...

11.02.2026 19:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Dewormer ivermectin as cancer cure? RFK Jr.'s NIH funds "absurd" study. There's no reason to think ivermectin cures cancer, but RFK Jr's NIH is on it anyway.

Waste, fraud, and abuse indeed. #Medsky arstechnica.com/health/2026/...

10.02.2026 19:17 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Coffee and Tea Intake, Dementia Risk, and Cognitive Function This prospective cohort study investigates whether coffee and tea intake are associated with dementia risk and cognitive function in female participants from the Nurses’ Health Study and male particip...

In this prospective cohort study of 131,821 individuals from 2 cohorts with up to 43 years of follow-up showed that higher caffeinated coffee intake was significantly associated with lower risk of dementia. #Medsky jamanetwork.com/journals/jam...

10.02.2026 17:11 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Trump administration removes Rainbow Flag from Stonewall National Monument The Trump administration removed a large Rainbow Flag from a flagpole at the Stonewall National Monument, the National Park Service confirmed to Gay City News

They have now removed the Pride flag from the Stonewall Inn.

Erasure. Just like the Nazis.

gaycitynews.com/trump-rainbo...

10.02.2026 05:12 β€” πŸ‘ 3160    πŸ” 1468    πŸ’¬ 124    πŸ“Œ 128
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10.02.2026 13:06 β€” πŸ‘ 17267    πŸ” 3790    πŸ’¬ 1134    πŸ“Œ 700
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After Republican complaints, judicial body pulls climate advice Meant to help judges handle scientific issues, document is now climate-free.

"In other words, [Republican state attorney generals are] arguing that, if someone is ignorant enough to start a suit based on ignorance of well-established science, then the Federal Judicial Center should join them in their ignorance."
arstechnica.com/science/2026...

10.02.2026 15:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Washington Post staffers fired while on international assignments have to start GoFundMe to get themselves home. Jeff Bezos didn’t have the money or heart to give the the fare.

08.02.2026 05:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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CDC Refuses to Take Blame for Measles Spiraling out of Control β€” Gizmodo In a WSJ editorial this week, CDC principal deputy director Ralph Abraham tried to push back against criticism.

CDC Refuses to Take Blame for Measles Spiraling out of Control #Medsky apple.news/AAVp3Td8MT3-...

08.02.2026 05:40 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0
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US-Russia nuclear treaty expires as warnings grow of new arms race β€” USA TODAY A nuclear treaty first signed in 2010 is expiring this week. If it's not replaced, experts say a global arms race could be in the cards.

U.S.-Russia nuclear treaty expires 02/05/2026 raising fears of new nuclear arms race apple.news/ANhF9SMoCRuO...

05.02.2026 05:16 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Nearly Half of Once Frequently Updated CDC Databases Are Now Outdated 46 percent of CDC databases that were updated at least monthly were no longer current in 2025, hindering timely, evidence-based policymaking and undermining public trust.

46 percent of CDC databases that were updated at least monthly were no longer current in 2025, hindering timely, evidence-based policymaking and undermining public trust.
#Medsky www.the-scientist.com/nearly-half-...

04.02.2026 18:54 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Opinion | Trump Isn’t Failing Because He’s Getting Bad Advice Trump’s advisers are terrible. That’s not the problem.

In @nytopinion.nytimes.com

β€œβ€˜Bad advice’ implies that Trump isn’t calling the shots, but Trump is constantly telling us otherwise,” Frank Bruni writes. β€œHe can’t be vulnerable to bad advice if he needs no advice in the first place.”

02.02.2026 20:50 β€” πŸ‘ 139    πŸ” 35    πŸ’¬ 24    πŸ“Œ 4
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Newborn dies after mother drinks raw milk during pregnancy Raw milk is promoted by anti-vaccine Health Secretary Kennedy.

#Medsky arstechnica.com/health/2026/...

04.02.2026 01:12 β€” πŸ‘ 5    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Resuming offshore wind is a step in the right direction for both energy independence and reducing the dependence on fossil fuels for energy.

02.02.2026 20:49 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Here’s a top CDC official claiming that the U.S. losing its measles elimination status would be β€œthe cost of doing business.”

We are governed by the dumbest people.

02.02.2026 20:45 β€” πŸ‘ 1015    πŸ” 284    πŸ’¬ 94    πŸ“Œ 24

Yes, this is a good idea. I'm sure there are no downsides to the secretly rewritten rules for nuclear reactors.

02.02.2026 20:41 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A century of hair samples proves leaded gas ban worked β€œWe should not forget the lessons of history. And the lesson is those regulations have been very important.”...

One of the best things done by the Nixon Administration was creating the Environmental Protection Agency (EPA). The EPA's banning of lead from gasoline has just been shown to have effectively reduced lead contamination in hair samples a least 10-fold since 1969. arstechnica.com/science/2026...

02.02.2026 20:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Texas Democrats make late push for social studies inclusion Concerned about Texas’ social studies overhaul, Democrats on the State Board of Education used a recent meeting to push for the inclusion of more Black and Indigenous perspectives and for young childr...

Concerned about Texas’ social studies overhaul, Democrats on the State Board of Education used a recent meeting to push for the inclusion of more Black and Indigenous perspectives and for young children to learn about the horrific nature of slavery.

02.02.2026 20:21 β€” πŸ‘ 131    πŸ” 36    πŸ’¬ 5    πŸ“Œ 4

Never forget what led to the flowering of knowledge, science, technology, and prosperity. Don't let short-sightedness kill the tree of knowledge after it has grown such wondrous fruit. nsf-gov-resources.nsf.gov/2023-04/Endl...

02.02.2026 20:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Guinea worm on track to be 2nd eradicated human disease; only 10 cases in 2025 When the eradication program began in 1986, there were a 3.5 million cases.

Congratulations to the Carter Center for leading the way to eradication of the Guinea worm. #Medsky arstechnica.com/health/2026/...

02.02.2026 20:19 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
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Bovino Is Said to Have Mocked Prosecutor’s Jewish Faith on Call With Lawyers

www.nytimes.com/2026/01/31/u...

31.01.2026 19:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Having that high-deductible health plan might kill you, literally With ACA tax credits gone, more people are turning to high-deductible plans.

#Medsky arstechnica.com/health/2026/...

30.01.2026 17:15 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation This clinical trial compares the effect of caffeinated coffee consumption vs abstinence from coffee and caffeine on recurrent atrial fibrillation.

Caffeine appears to reduce atrial fibrillation or flutter in coffee drinkers. N = 200 (69 Β± 11 years; 71% male) randomized 1:1 to
coffee vs no coffee. Outcome: AFib/flutter with coffee (47%) vs none (64%). HR = 0.61 [95% CI, 0.42–0.89]; P = .01). AEs same. #Medsky jamanetwork.com/journals/jam...

27.01.2026 20:42 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Doomsday Clock Timeline - Bulletin of the Atomic Scientists A visual history of the Clock’s shifts and cultural impact since 1947.

Here is the history of changes to the Doomsday Clock since its inception in 1947. thebulletin.org/doomsday-clo...

27.01.2026 19:53 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

The Doomsday Clock has just been advanced to 85 seconds to Midnight. Things are not going well in our world. We are running out of time to fix it.

27.01.2026 19:51 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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International Holocaust Remembrance Day - Wikipedia

International Holocaust Remembrance Day (January 27th) en.wikipedia.org/wiki/Interna...

27.01.2026 19:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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❗️The US has signaled to Kyiv that it will provide Ukraine with security guarantees only if it agrees to a deal involving withdrawal from territory (Donbas), – FT sources.

27.01.2026 07:19 β€” πŸ‘ 55    πŸ” 23    πŸ’¬ 42    πŸ“Œ 15

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