Natalie Stanley

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Mickey Mouse Packing Struggles GIF ALT: Mickey Mouse Packing Struggles GIF

trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂

Brain aging and rejuvenation at single-cell resolution This review by Sun, Nagvekar, Pogson, et al. focuses on single-cell “omics” studies of brain aging to highlight changes in different cell types and cell-cell interactions during aging and in response ...

beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social !
www.cell.com/neuron/fullt...

What about students who don’t check their email 😂

Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.

Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...

Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity
www.researchsquare.com/article/rs-7...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...

Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com
www.nature.com/articles/s41...

Congrats!!!

Now out in @natmachintell.nature.com

TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)

📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨‍💻: github.com/pirl-unc/tcr_translate

tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works

Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.

Open weights, go wild.

Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social
www.biorxiv.org/content/10.1...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...

@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief
www.cell.com/trends/pharm...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social
www.nature.com/articles/s41...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease Microglia-mediated neuroinflammation drives Alzheimer's disease (AD) pathogenesis, yet the underlying mechanism is poorly understood. Song et al. demonstrate that toxic amyloid-β induces oxidation and...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com

Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with multiple sclerosis activity
www.science.org/doi/10.1126/...

Restoring resident tissue macrophages to combat aging and cancer - Nature Aging Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...

Perspective @nataging.nature.com @miriammerad.bsky.social
Restoring resident tissue macrophages to combat aging and cancer
www.nature.com/articles/s43...

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....

This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis Objectives Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR-MS). We assessed early cellular B-cell profiles in patients...

Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

onlinelibrary.wiley.com/doi/10.1002/...

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social
www.nature.com/articles/s41...

The brain drain puts aging myelin in deep trouble - Nature Neuroscience In this issue, Stamenkovic et al. describe deep in vivo imaging of the brain vasculature to document its evolution during aging, which identifies a unique vulnerability at the site of convergence of c...

When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function.

New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social
www.nature.com/articles/s41...

Regional heterogeneity of the blood-brain barrier - Nature Communications The blood-brain barrier (BBB) regulates the extracellular composition of the central nervous system (CNS), but it is not known whether its properties differ across CNS regions. Here, the authors show ...

Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕
www.nature.com/articles/s41...

Did you ever wonder what insights hide in the multiplets that are usually discarded in flow cytometry? 🫧 Find out in the first publication of my PhD, now out in Nature Methods! www.nature.com/articles/s41... (1/4)

Alzheimer’s disease transcriptional landscape in ex vivo human microglia www.nature.com/articles/s41...

The brain fires up immune cells when sick people are nearby When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.

The brain activates front-line immune cells in response to the mere sight of a sick person, mimicking the body’s response to an actual infection.

www.nature.com/articles/d41...

Review of the possible role of Matzinger's "danger theory" of damage-associated molecular patterns in CNS as drivers of increased incidence of major depressive disorder www.science.org/doi/10.1126/...