Natalie Stanley

Atlas-guided discovery of transcription factors for T cell programming - Nature A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunother...

New study—and exciting collaboration with Wei Wang, Cong Liu (UCSD), and Kay Chung (new lab at UNC)—that provides a platform for designing T cells into specific states. We identified state-selective TFs for CD8 T cell states that enable “recipes” for cell engineering! www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/

www.nature.com/articles/s41...

Sounds amazing! - am definitely going to give this a read.

Fun friend group

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brain immune activity and show that targeting immune cells with an engineered IL-10 variant rebalances inflammatory programs in microglia, improves neurogenesis, and enhances cognition in old mice.

Online now: Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

@biorxivpreprint.bsky.social The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells @cannalab.bsky.social
www.biorxiv.org/content/10.6...

Our intellectual epicenter :)

Review @moltherapy.bsky.social
Redefining Multiple Sclerosis with CAR-T Cell Therapy
www.cell.com/molecular-th...

Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...

Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Mickey Mouse Packing Struggles GIF ALT: Mickey Mouse Packing Struggles GIF

trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂

Brain aging and rejuvenation at single-cell resolution This review by Sun, Nagvekar, Pogson, et al. focuses on single-cell “omics” studies of brain aging to highlight changes in different cell types and cell-cell interactions during aging and in response ...

beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social !
www.cell.com/neuron/fullt...

What about students who don’t check their email 😂

Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.

Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...

Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity
www.researchsquare.com/article/rs-7...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...

Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com
www.nature.com/articles/s41...

Congrats!!!

Now out in @natmachintell.nature.com

TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)

📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨‍💻: github.com/pirl-unc/tcr_translate

tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works

Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.

Open weights, go wild.

Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social
www.biorxiv.org/content/10.1...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...

@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief
www.cell.com/trends/pharm...

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social
www.nature.com/articles/s41...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease Microglia-mediated neuroinflammation drives Alzheimer's disease (AD) pathogenesis, yet the underlying mechanism is poorly understood. Song et al. demonstrate that toxic amyloid-β induces oxidation and...

Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com