Immunity (@cp-immunity) — Bluesky Profile

20 minutes ago

MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species Resident macrophage maturation and tissue-specific identity depend on transcriptional programming, yet how conserved regulators universally drive these programs remains unresolved across tissues. Vanneste et al. identify MafB as a key transcriptional regulator that directly orchestrates conserved gene networks from mouse to human, thereby sustaining macrophage function and multi-organ tissue homeostasis.

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5 hours ago

A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria Understanding immunity against Plasmodium vivax, a leading cause of malaria, will accelerate development of vaccines, which are currently lagging. Opi et al. identify important mechanisms and target antigens of protective P. vivax immunity in children, including combinations of responses that afford greater protection, revealing pathways for vaccine development.

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7 hours ago

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer (Immunity 58, 2524–2540.e1–e5; October 14, 2025)

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21 hours ago

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection γδIELs are essential for intestinal homeostasis, but how their differentiation and cytotoxic function are regulated remains unclear. Xie et al. demonstrate two functionally distinct γδIEL subsets, CD160+TCF1+BCL6+ stem-like and GZMB+BLIMP1+ effector-like cells, and show that Salmonella infection promotes IL-12/TCR-STAT4-BLIMP1 signaling to drive effector differentiation and cytotoxicity, linking γδIEL responses to microbial-derived cues for protective gut immunity.

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1 day ago

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons produce substance P and TAFA4, which act in a tissue-specific manner to modulate inflammation and promote disease tolerance without affecting viral clearance.

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1 day ago

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice Broadly neutralizing antibodies are promising therapeutics for ending the HIV pandemic; however, their clinical efficacy is undermined by viral escape. Galvez, Nitido, et al. could drive the therapeutic outcomes of vectored immunotherapy in humanized mice by modulating the fitness costs and resistance benefits of HIV escape from AAV-vectored bNAbs.

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1 day ago

Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis Microplastics pose a substantial threat to human health, but their effect on phagocytosis is unknown. Codo et al. find that polystyrene microplastics accumulate in different types of tissue-resident phagocytes, disrupting homeostatic clearance of apoptotic cells (efferocytosis) and fungal phagocytosis. Disrupted efferocytosis was caused by methylglyoxal (MGO) glycation of glucose-6-phosphate dehydrogenase but was reversed by overexpression of the MGO detoxification glyoxalase-1.

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1 day ago

Antibody-mediated feedback modulates interclonal competition in the germinal center Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the outcomes of contemporaneous germinal centers (GCs) and find that antibody-mediated feedback dampens the expansion of GC B cells with competing specificities, thereby regulating immunodominance and clonal diversity in GCs.

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2 days ago

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis Emotional stress worsens atopic dermatitis and its overall burden, yet the underlying mechanisms remain unclear. Xie et al. reveal that anxiety amplifies atopic dermatitis through sympathetic nervous system activation. Sympathetic release of norepinephrine engages β2-adrenergic receptor signaling on basophils, which then release the chemokine CCL6 to drive basophil recruitment and exacerbate skin inflammation.

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2 days ago

The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors Tumor-infiltrating NK cells are often dysfunctional. Ji et al. show that the solid tumor microenvironment metabolome drives proteostasis imbalance and dysfunction in tumor-infiltrating NK cells and demonstrate that deletion of Fli1, a transcriptional repressor of the unfolded protein response, enhances proteostasis and NK cell persistence, resulting in improved antitumor responses in vivo.

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2 days ago

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 promotes the formation of positively curved membrane regions that recruit and activate caspase-4, providing mechanistic insights into immune recognition of Gram-negative bacteria.

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2 days ago

Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading Feedback from circulating antibodies can shape initiating immune responses. Yan et al. examine ongoing germinal center (GC) responses upon immunization with an mRNA-LNP-encoded membrane-bound immunogen displaying three conserved HIV-1 envelope epitopes and find antibody-mediated intra-epitope competitive effects and a contribution of local antibodies to determining B cell residency in GCs and affinity maturation.

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3 days ago

Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation When food availability is reduced, it is unclear how the host adapts to support glucose-demanding immune processes while preventing hypoglycemia. Here, Menezes-Silva, Jeong, et al. demonstrate that glucocorticoids (GCs) maintain immune homeostasis, and balance the tradeoff between effective pathogen control and glucose conservation, during dietary restriction (DR).

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3 days ago

Out of many, IL-1 Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al...

@cp-immunity.bsky.social spotlight
Defined molecular and anatomical pathway through which inflammatory signals are sensed by the brain and translated into active social withdrawal
www.cell.com/immunity/ful...
on @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

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3 days ago

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics to the heart from the lung largely within pro-DC3s, which unleashes a damaging type I interferon program that compromises cardiac function.

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3 days ago

Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social
www.cell.com/immunity/ful... @dukeeyecenter.bsky.social

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4 days ago

[Benamar] Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in MS [Mehdi Benamar] Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis cell.com/immunity/fulltext/S1074-7613(25)00418-2

Benamar 's talk is now on YouTube!

youtu.be/vSqwQve-W-0

Paper link! @cp-immunity.bsky.social
www.cell.com/immunity/abs...

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5 days ago

HIF-1α activity sustains lung-resident CD4+ T cells that organize an IL-21-dependent immune network, integrating local protection during infection and cancer @cp-immunity.bsky.social @immunologyking.bsky.social @grace-unibasel.bsky.social @jeandelima.bsky.social
www.cell.com/immunity/ful...

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4 days ago

Resident tissue macrophages maintain intraocular pressure homeostasis. @cp-immunity.bsky.social www.cell.com/immunity/ful...

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4 days ago

Resident tissue macrophages maintain intraocular pressure homeostasis Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue macrophages have a specialized role in IOP homeostasis by regulating extracellular matrix turnover. These findings identify an integral homeostatic role for tissue-resident macrophages in resistance-generating tissues that are dysfunctional in glaucoma.

Online now: Resident tissue macrophages maintain intraocular pressure homeostasis

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6 days ago

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...

Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1α in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10).

www.cell.com/immunity/ful...

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6 days ago

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and temporal distribution of lung HIF-1α-active CD4⁺ T cells. They show that HIF-1α activity sustains lung-resident CD4+ T cells that organize an IL-21-dependent immune network, integrating local protection during infection and cancer.

Online now: HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

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1 week ago

Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis. The resulting macrophage death amplifies autoimmune tissue inflammation through the release of pro-inflammatory mediators.

Online now: Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis

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1 week ago

Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor (Immunity 58, 2320–2335.e1–e9; September 9, 2025)

Online now: Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor

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1 week ago

We’re offering exclusive in-person 1:1 meetings with Cell Press editors for participants of @CellSymposia #CSImmuneHomeostasis26 in Shanghai, China (May 11–13, 2026).
Early bird registration ends today!
http://dlvr.it/TRKq2Y

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1 week ago

Human immune aging Artyomov and colleagues provide an overview of studies on age-related changes in the human immune system, from early flow cytometry research to more recent findings using single-cell and advanced cyto...

Curious about human immune aging and the cutting-edge tools now used to study it? Check out Maxim Artyomov’s review in @cp-immunity.bsky.social. A great primer before the Immunoschool kicks off in 3 weeks, www.cell.com/immunity/ful...

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1 week ago

New paper reveals how the human immune system fights #malaria caused by Plasmodium vivax, opening new avenues to develop #vaccines against the most widespread form of malaria. Published in @cp-immunity.bsky.social
@burnetinstitute.bsky.social @wehi-research.bsky.social
doi.org/10.1016/j.im...

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2 weeks ago

Intermittent fasting evicts long-lived plasma cells from survival niche Nature Reviews Immunology - Zhu et al. report in Immunity that ketogenesis resulting from intermittent fasting causes the downregulation of CXCR4 expression on plasma cells, triggering their egress...

NEW online: Highlight of an @cp-immunity.bsky.social paper by @lab-of-plasma-cell.bsky.social showing that intermittent fasting in mice impairs the maintenance of humoral memory by depleting long-lived plasma cells.

rdcu.be/e53h0

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1 week ago

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice @cp-immunity.bsky.social @ragoninstitute.bsky.social
www.cell.com/immunity/ful...

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2 weeks ago

MafB as a key transcriptional regulator that directly orchestrates conserved gene networks from mouse to human, thereby sustaining macrophage function and multi-organ tissue homeostasis @cp-immunity.bsky.social
www.cell.com/immunity/ful... @dovneste.bsky.social

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