Kelly Sullivan

A new Crnic Institute study reveals people with Down syndrome show consistent signs of liver dysfunction across the lifespan.With support from the Global Down Syndrome Foundation, this research offers hope for simple, actionable interventions to support better health. Learn more at bit.ly/4jQOLHD.

Altered hepatic metabolism in Down syndrome Dunn et al. show that individuals with Down syndrome display widespread evidence of altered hepatic function in the plasma proteome and metabolome, typified by elevated plasma bile acids. Using a mous...

Excited to share this work. A huge effort from many team members, led by former @cuhmggp.bsky.social PhD student and current @crnicinstitute.bsky.social Post-doc, Dr. Lauren Dunn!
Altered hepatic metabolism in Down syndrome: Cell Reports www.cell.com/cell-reports...

Bruce Dickinson with the anthem!

"Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model," published in iScience, a Cell Press Journal

Congratulations to Dr. Paula Arya, Dr. Joaquin Espinosa and Dr. Kelly Sullivan for leading a new study published in iScience entitled "Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model." Read more at https://bit.ly/3Io31cK.

Postdoc Appreciation Week Brian Niemeyer, PhD Sara Sherman, PhD Ariel Timkovich, PhD

As Postdoc Appreciation Week ends, we celebrate our three outstanding postdocs at the Crnic Institute. Thank you, Dr. Brian Niemeyer, Dr. Sara Sherman and Dr. Ariel Timkovich, for your invaluable contributions. Our mission to advance Down syndrome research wouldn’t be possible without you!

We need research heroes! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together to better understand hearing and balance in people with Down syndrome from September 8-13 at Children's Hospital Colorado. Learn more: bit.ly/HearinginDS

Registration is open for the annual Crnic Institute Down Syndrome Research Symposium on September 15, 2025! This in-person event will take place on the 2nd floor of the Anschutz Health Sciences Building. Register today at https://bit.ly/DS-Symposium.

Congratulations to Dr. Kelly Sullivan, director of the Crnic Institute’s Experimental Models Program and associate professor at @cupediatrics.bsky.social‬, on presenting ”The Interferonopathy of Down Syndrome,” and to Rachel Shropshire for winning Top Student Poster at this year’s DSMIG Symposium!

The 2026 Program will heavily emphasize co-occurring conditions and tissue systems affected by T21. We encourage diversity in the composition of symposia speakers with respect to geography, academic rank, and gender. Society members at all career stages are welcome to submit symposia.

The theme for the 6th International Conference of the Trisomy 21 Research Society will be, “T21: Insights from Across the Lifespan”. Each symposium will consist of four speakers in a 2-hour block and should include both basic and translational components to foster discussion among research teams.

Planning for next years T21RS International Conference in Denver is under way! Call for Symposia will open on August 15. If you have any questions, please don't hesitate to reach out.

www.t21rs.org/5th-t21rs-in...

JSCBB Biotech Building in Boulder, CO

Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado!

jobs.colorado.edu/jobs/JobDeta...

🧪🧬 #TESky #interferosky

Research participant taking a hearing test wearing headphones.

New research opportunity! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together in Dallas, TX, to better understand hearing and balance in people with Down syndrome. Compensation is provided. Learn more and schedule an appointment at bit.ly/HearinginDS.

Some news....Rome is not fully burned down.

T32 PhD Training Grant was officially awarded, and two weeks ago, the NIH offered more support than requested to increase the # trainees in the unique program. Office chair with me in it levitated.

Calling Microbime PhD'ers to @psumbiome.bsky.social 🎓

NIH and FDA hosted a workshop on July 7 on efforts to reduce the use of animal models in research, NIH has formally announced a policy change. The agencies have invited comments through the workshop’s webpage. PLEASE COMMENT. The portal will be open until 5pm ET on Monday, July 14 (TODAY).

Congratulations to Dr. Jason Wilson of @cuhmggp.bsky.social on successfully defending his dissertation yesterday! You can check out some of his work here: www.biorxiv.org/content/10.1...

Grateful to meet with students from CU Boulder’s CU in DC program. Appreciated their thoughtful and insightful questions!

PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation Nature Communications - Here they show that heterodimerization of the receptor tyrosine kinases PDGFRa and PDGFRb negatively affects downstream ERK1/2 signaling and cellular proliferation, due in...

Delighted to share our updated work, led by postdoctoral fellow Dr. Maria Campaña, published in @natcomms.nature.com: rdcu.be/em66g, PDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

Maybe someone needs to say this out loud, but computers can't model the physiology of a living organism because we don't know how many of the parts of an organism work, which is uhhh... why we do the research with the animal models?

Trump budget cuts threaten Anschutz healthcare, research and jobs, officials say - Sentinel Colorado "This is life and death stuff for Americans and for Coloradans." - Rep. Jason Crow

ICYMI - “This is life and death stuff for Americans and for Coloradans.” – Rep. Jason Crow

sentinelcolorado.com/metro/trump-...

#TrumpCuts #COpolitics #DOGE

Now they need to settle down.

CU Anschutz Chancellor Don Elliman, U.S. Representative Jason Crow and Vice Chancellor for Research Thomas Flaig, MD, sit at the roundtable

Representative Jason Crow looks into a microscope during a tour on the CU Anschutz campus.

Thank you Congressman @crow.house.gov for visiting the #CUAnschutz Medical Campus to learn more about our latest breakthroughs and the vital role of federal funding in driving lifesaving new medical discoveries.

It was a pleasure to have Kristina Sisneros from Regis University for her GLOBAL Inclusive Program Internship! Thank you to GLOBAL for supporting this amazing opportunity, and congratulations to Kristina on all her hard work.

Wow.

Hi Folks! Myself and the Barberan Lab at U of A are still looking for a PhD student to work on an NSF funded project exploring effects of fire and invasion on soil microbes. We are looking for someone to start in Fall! SOON! Email me if you are interested! PLS Repost!

@EsaSeeds

striking to me that this interview ends with him plaintively pleading for other university leaders to speak up: "I don’t think this is all about Princeton. It’s about what’s happening in the United States. I think this would be so much stronger if many more of my fellow presidents were speaking up."

Trump promised scientific breakthroughs. Researchers say he’s breaking science. NIH funding for biomedical research has abruptly fallen by billions of dollars, with many grant decisions on hold. Trump officials say they’re reviewing the agency.

Powerful new Washington Post story up...

wapo.st/426d9fT

(Gift link)

1/n

Are you wearing different socks to celebrate #WorldDownSyndromeDay ?

Join in!!! It's fun!!!

Funding cuts to CU-Anschutz could erase years of medical research contributed by patients, advocates fear NIH funding cuts could halt years of progress on medical research contributed by patients at Colorado's CU-Anschutz campus.

Was very excited to host Senator Hickenlooper in my lab this past week, as well as be involved in a panel discussion around the important of federal funding for science!

coloradosun.com/2025/03/19/n...

Advocating for increased awareness and research on Down syndrome World Down Syndrome Day, observed annually on March 21 and recognised by the UN since 2012, aims to raise awareness of Down syndrome to help people better understand and support those with the conditi...

Tomorrow is World Down Syndrome Day (3/21)! We have made great strides in understanding Down syndrome and improving healthspan for this amazing community, but there is much work to be done. Honored to be part of the Trisomy 21 Research Society Executive Board. www.thelancet.com/journals/lan...