Sheerazed Boulkroun

5/5
@straversallard.bsky.social, Stéphanie Baron, David Penton Ribas, @fabiofrosa.bsky.social, Maria-Christina Zennaro

4/5
Thank you to all the co-authors and collaborators !

Bakhta Fedlaoui, Teresa Cosentino, Zeina Al Sayed, Rita Alexandre Coelho, Isabelle Giscos-Douriez, Nicolò Faedda, @mayfayad.bsky.social, Jean-Sébastien Hulot, Chris Magnus, Scott Sternson

3/5
Applying this chemogenetic approach could also enable the development of a new inducible mouse model of primary aldosteronism, providing a valuable tool for dissecting the mechanisms underlying aldosterone producing adenoma development and for evaluating new therapeutic strategies.

2/5
This innovative model could be used to test the molecular impact of new treatments for primary aldosteronism in vitro.

1/5
We demonstrated that increased expression of CYP11B2 and stimulation of the mineralocorticoid biosynthesis pathway are associated with a decrease of cell proliferation and an increase of apoptosis, indicating that additional events may be required for the development of APA.

I’m thrilled to see our latest paper published in Hypertension! 🎉
lnkd.in/e5J92MWe

We developed a new adrenocortical cell model reproducing the major features of cells harboring a KCNJ5 mutation.

@aldolabz.bsky.social @parcc-inserm.bsky.social @upcite.bsky.social

1/5
We demonstrated that increased expression of CYP11B2 and stimulation of the mineralocorticoid biosynthesis pathway are associated with a decrease of cell proliferation and an increase of apoptosis, indicating that additional events may be required for the development of APA.

#InternationalWomensDay !

Stand up for science!

Opening of the #JHTA2024 by Beatrice Duly-Bouhanick, president of the #sfhta
@aldolabz.bsky.social

Amazing COMETE meeting to close the adrenal year with great science and old and new friends!

Nice COMÈTE day with the French adrenal family ! @jeromebertherat.bsky.social @boulkrounshee.bsky.social @aldolabz.bsky.social

We’re new to Bluesky, but not to #endocrinology. Since 1946, we’ve been dedicated to advancing endocrine science and health.

We’re here to connect with researchers, clinicians, nurses and anyone interested in the vital role of #hormones in our lives.

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice The functional role of peripheral GIPR action in weight loss is yet to be fully defined in a preclinical setting. Here, Yu et al. propose a mechanism whereby inducible activation of GIPR in adipocytes promotes energy wasting through futile calcium cycling, triggering profound weight loss in the obese state.

The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice 🧪

www.cell.com/cell-metabol...

We are pleased to receive at the PARCC Dr Kotaro Sasaki from University of Pennsylvania for a masterclass entitled « Reconstitution of human adrenocortical development using pluripotent stem cells »
@aldolabz.bsky.social @fabiofrosa.bsky.social

Prevalence and Risk Factors for Secondary Hypertension in Young Adults | Hypertension BACKGROUND: The prevalence of secondary causes of hypertension in young adults is unknown, and therefore, there is no consensus about the indication of screening of secondary hypertension (2HTN) in th...

Primary aldosteronism ist the most frequent cause of secondary hypertension in young adults aged 18-40 yrs! ahajrnls.org/4fLH1Uo

Congrats!

Merci!
Je decouvre