Sandhya Koushika

Our dept @tifr.res.in ‬ran an MSc by research for ~25yrs. Our last batch graduated this month. Several headed to excellent PhD programs, some to jobs.

Congratulations and good luck for many fun adventures.

👏🏾Sohan Seal from my lab headed for a PhD to @mpi-cbg.de. 2nd from L, row 2

😔 Doing science has taken on elements of a corporation w/ writing=one "vertical". Output of research as patents and IP seems to be another. Metrics is a temple at which we worship at.

Sometimes overlooked is serendipity, small groups that meander & in this context the idea that writing is thinking.

Important.......

⭐ 🌟 image

Organ clocks for post-menopausal women taking estrogen or not taking estrogen

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...

YouTube video by Morris Maduro Worm Show 2025

Bummed I missed the worm meeting this year but happy Worm Show was posted on YouTube. Bravo Morris and Curtis! www.youtube.com/watch?v=HXgU...

We are looking forward to the Worm Meeting 2027 and thank
Suhong Xu(Zhejiang University School of Medicine, Hangzhou, China),
Kavita Babu (Indian Institute of Science, Bangalore, India), and
Erik Andersen (Johns Hopkins
University Baltimore, USA)
for organising. #worm25

Worms with neurons, a bracelet? Promise to buy. Missing #Worm25

As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well.
This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25

Role of clathrin adaptor complex AP3 in secretion of dense core vesicles from the Sahu lab, NBRC.

Badal from my lab has added an experiment testing the role of AP3 in secretion of neuropeptides in C. elegans.

❤️

Favorite moment of the day: "Do Genetics" -Nobel Prize Winner Gary Ruvkun #worm25

WormBase site will be frozen and migration to Genome Alliance

Paul Sternberg with important WormBase news #worm25

Folks at #worm25 please post. For those of us who did not make it we have to experience it vicariously through your posts.

“Do you have any advice for aspiring young scientists?”

“Do genetics.” *mic drop*

#worm25

For #worm25, here are updated lists of 200+ researchers for the #Celegans community to easily follow:

C. elegans #1 (150 full) - go.bsky.app/HP1h3nW
C. elegans #2 (50+) - go.bsky.app/J7soTHG

==> Reply to this if you'd like to be added!

cc: @genetics-gsa.bsky.social

#CeleganSky 🪱 🧪 1/n

👌🏽

Nice study

Looking forward to working with @network-alba.bsky.social

😂

Bacterial metabolism of tryptophan causes toxicity in Caenorhabditis elegans Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nico...

Pleased to share our latest work by Shivani and Subodh. We show that the essential amino acid Trp is highly toxic to C. elegans. It turns out that the bacterial diet is the culprit. Bacterial metabolism of Trp to indole causes the toxicity.

www.biorxiv.org/content/10.1...

NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans https://www.biorxiv.org/content/10.1101/2025.06.09.658633v1

😍

This was a brilliant public talk @tifr.res.in by Nobel laureate Prof. Brian Schmidt.
It was informative, simple to understand for people outside the field, funny & inspiring.

You can watch a recording here.
youtube.com/watch?v=awik...

Based in Mumbai? Interested in general in science. Come to the lovely @tifr.res.in campus to listen to Paul Nurse.

TODAY........

A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment Axon initial segment (AIS) Kv1 K+ channels are recruited by a unique clustering mechanism different from other AIS ion channels.

'A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment'

www.science.org/doi/10.1126/...

Not just the publishing system but the reward rubric where each authors contribution in an multi-author paper is examined. Additional aspect compared to a few decades ago, long papers have become the norm. Reviewers expect a more 'complete story' w/ several complementary approaches, so more authors.

Looking forward to this fun meeting

".....but a key feature of this community became abundantly clear: Worm people tend to help one other. They readily share insights, lab processes, even worms themselves."

So true. The worm community is the best.