Sandhya Koushika's Avatar

Sandhya Koushika

@wormlockholmes.bsky.social

Cellular neurobiologist TIFR India who loves genetics, live imaging and worms. Science is fun, let's go exploring. Sci comm, write bad poetry, 2 girl mom lab: https://tinyurl.com/5n7s6ens https://scholar.google.co.in/citations?user=c4zDSQ8AA

2,457 Followers  |  476 Following  |  281 Posts  |  Joined: 19.10.2023  |  1.8682

Latest posts by wormlockholmes.bsky.social on Bluesky

Fun hear.

28.11.2025 06:28 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Important consideration when doing imaging

10.11.2025 10:41 โ€” ๐Ÿ‘ 5    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Wonderful initiative linking @biorxivpreprint.bsky.social to @qedscience.bsky.social. ๐Ÿ‘๐Ÿฝ๐Ÿ‘๐Ÿฝ @odedrechavi.bsky.social & @richardsever.bsky.social

07.11.2025 10:44 โ€” ๐Ÿ‘ 7    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Cool study

07.11.2025 10:37 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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FPbase Fluorescence Spectra Viewer An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.

The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!

www.fpbase.org/spectra/

04.11.2025 15:03 โ€” ๐Ÿ‘ 111    ๐Ÿ” 36    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 2

super interesting-dig in

03.11.2025 16:34 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Field notes from a weekend PI at the #microscope: vesicle cargo lanes lighting up in real time like @FedEx. This is the ML1N PX domain in a fibroblast. Hot damn, thereโ€™s mind-blowing action under the surface of cells: this video shows 2 min of time ๐Ÿคฏ #Cellbio #MicroscopyMonday #SciArt #SciComm

22.09.2025 15:42 โ€” ๐Ÿ‘ 52    ๐Ÿ” 13    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Disruption of theta-timescale spiking impairs learning but spares hippocampal replay The ability to rapidly learn and retrieve salient information about new environments is critical for survival. In mammals, the hippocampus plays a crucial role in that learning. Specialized features o...

Spatial memory & motion are expressed simultaneously during behaviours. Synchronization of hippocampal dynamics (HD) occurs during movement. Disrupting HD during locomotion impairs memory. โญ work @rhythmicspikes.bsky.social @ncbsbangalore.bsky.social in #IAN25
Read more: tinyurl.com/4dah3xw6

30.10.2025 13:06 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿš€ #ALBADiversityWeek 2025 starts today! We celebrate diversity & intersectionality by highlighting key activities and sharing valuable resources.
๐Ÿ‘€ Stay tuned all week as we revisit achievements and launch new initiatives. Share our posts to join the #GlobalDiversityAwarenessMonth celebration. ๐Ÿงต

27.10.2025 11:33 โ€” ๐Ÿ‘ 7    ๐Ÿ” 9    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
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Gut feeling C. elegans uses a protein located in specific neurons to detect toxic food and shut down the digestive system.

When its meal turns toxic, the tiny worm #CElegans shuts down digestion thanks to a single protein that links its โ€œtasteโ€ neurons to the gut.

11.10.2025 10:02 โ€” ๐Ÿ‘ 10    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

Super interesting-dig in

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance | Science www.science.org/doi/10.1126/...

27.09.2025 01:36 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The curious case of the tigers who changed their stripes A century ago, Indiaโ€™s tigers were on the brink of extinction. Slowly, their numbers have rebounded. But that ecological success has prompted a dire problemโ€”and a race to save many of them from geneti...

A 19-page article in the National Geographic that covers the work of @uramakri.bsky.social @ncbsbangalore.bsky.social @tifr.res.in on black tigers, mutation load and corridors for tiger migration.

Important story and impactful work.
๐Ÿ‘๐Ÿพ

www.nationalgeographic.com/animals/arti...

16.09.2025 03:23 โ€” ๐Ÿ‘ 3    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

What a feast....

01.09.2025 15:01 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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This award aims to highlight outstanding research by active neuroscientists working in countries underrepresented in neuroscience publications and conferences. @network-alba.bsky.social @sfn.org @ibroorg.bsky.social @fens.org

21.08.2025 16:01 โ€” ๐Ÿ‘ 6    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Our worm lab is recovering from a mite attack. Trainees devoted hours to cleanup

A mite or two or an army
They are hateful and smarmy
Our helpless little ones
Crushed by their whirling carny

Hello give up not
Gather all the stock
Pick, bleach, clean
Burn to death a game well fought

21.08.2025 09:03 โ€” ๐Ÿ‘ 11    ๐Ÿ” 1    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 0
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๐ŸšจOnly 4 days to apply!!!๐ŸšจJoin the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries๐Ÿ”ฌConnect with top mentors & earn $500 to attend the SDB Annual Meeting ๐ŸŽ‰! ๐Ÿ‘‰ www.sdbonline.org/science_comm... #SciComm #DevBio

12.08.2025 13:29 โ€” ๐Ÿ‘ 13    ๐Ÿ” 11    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3

Thank you--this is cool

12.08.2025 07:09 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

How widespread is heat-dependent sterility. Is this only in C. elegans? Does it happen in other nematodes or other cold-blooded animals?

12.08.2025 06:23 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Foliar mRNA spray induces protein synthesis in monocot crop and dicot model plant species In planta gene expression via exogenous mRNAs has a wide range of potential biotechnological applications from genome editing to plant protection and to circumventing tissue culture. Yet, regarding mR...

๐Ÿ˜ฎ Just WOW!!

Spray GFP mRNAs on plant leaves and the leaves translate this and you get glowing leaves.

www.biorxiv.org/content/10.1...

12.08.2025 06:22 โ€” ๐Ÿ‘ 51    ๐Ÿ” 12    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 5

Really interesting preprint on how the nervous-system modulates heat-dependent fertility. Work from @ethanewe.bsky.social from @odedrechavi.bsky.social lab. May well be relevant in a planet that is heating up.

12.08.2025 06:15 โ€” ๐Ÿ‘ 7    ๐Ÿ” 3    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

Loved this @heiman.bsky.social

11.08.2025 05:40 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Read today

"Comparison is the thief of Joy"

True that

09.08.2025 14:27 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Our dept @tifr.res.in โ€ฌran an MSc by research for ~25yrs. Our last batch graduated this month. Several headed to excellent PhD programs, some to jobs.

Congratulations and good luck for many fun adventures.

๐Ÿ‘๐ŸพSohan Seal from my lab headed for a PhD to @mpi-cbg.de. 2nd from L, row 2

30.07.2025 10:07 โ€” ๐Ÿ‘ 9    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ˜” Doing science has taken on elements of a corporation w/ writing=one "vertical". Output of research as patents and IP seems to be another. Metrics is a temple at which we worship at.

Sometimes overlooked is serendipity, small groups that meander & in this context the idea that writing is thinking.

10.07.2025 07:30 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Important.......

08.07.2025 23:30 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

โญ ๐ŸŒŸ image

08.07.2025 16:12 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Organ clocks for post-menopausal women taking estrogen or not taking estrogen

Organ clocks for post-menopausal women taking estrogen or not taking estrogen

New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...

05.07.2025 17:09 โ€” ๐Ÿ‘ 285    ๐Ÿ” 57    ๐Ÿ’ฌ 17    ๐Ÿ“Œ 4
Worm Show 2025
YouTube video by Morris Maduro Worm Show 2025

Bummed I missed the worm meeting this year but happy Worm Show was posted on YouTube. Bravo Morris and Curtis! www.youtube.com/watch?v=HXgU...

05.07.2025 02:39 โ€” ๐Ÿ‘ 9    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

We are looking forward to the Worm Meeting 2027 and thank
Suhong Xu(Zhejiang University School of Medicine, Hangzhou, China),
Kavita Babu (Indian Institute of Science, Bangalore, India), and
Erik Andersen (Johns Hopkins
University Baltimore, USA)
for organising. #worm25

02.07.2025 18:34 โ€” ๐Ÿ‘ 36    ๐Ÿ” 10    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Worms with neurons, a bracelet? Promise to buy. Missing #Worm25

02.07.2025 07:22 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

@wormlockholmes is following 20 prominent accounts