Yash Shukla

Landscape and regulation of mRNA translation in the early C. elegans embryo Using ribosome profiling, Shukla et al. characterize dynamic translational regulation of maternal mRNAs during the first four cell cycles of C. elegans development. Their findings demonstrate how post...

Post 5/5:
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science

Post 4/5:
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.

Post 3/5:
What we discovered:

Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously

Post 2/5:
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩‍🍳

Landscape and regulation of mRNA translation in the early C. elegans embryo Using ribosome profiling, Shukla et al. characterize dynamic translational regulation of maternal mRNAs during the first four cell cycles of C. elegans development. Their findings demonstrate how post...

How do tiny worm embryos decide which cells become muscle, nerve, or gut - all without reading any new DNA? 🤔
Our new Cell Reports paper explores this fascinating question using C. elegans embryos.
cell.com/cell-reports/fulltext/S2211-1247(25)00549-2

🧵 Thread below 👇

Ever wondered how several individual RBPs cooperate to repress translation?

Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!

www.biorxiv.org/content/10.1...

Awesome stuff! I use patchwork for most of my work. Was curious about the extra flexibility that your library provides

Landscape and regulation of new protein translation in the early C. elegans embryo Translation of maternal mRNAs is crucial for early embryonic development. In C. elegans, cell fates become determined from the first division without new transcription, making this organism ideal for ...

Check out this pre-print to see what happens in germ- granules : www.biorxiv.org/content/10.1...

"This helps explain how embryos develop without new transcription - with implications across species! Excited to hear your thoughts and welcome feedback from the community!
#Preprint #MolBio #SciComm 3/3"

"Using low-input ribosome profiling, we uncovered how cells control protein production in the first four cell divisions. Key finding: mRNA localization tightly links to translational efficiency, with OMA-1 emerging as a crucial player! 2/3"

Landscape and regulation of new protein translation in the early C. elegans embryo

"New preprint! 🧬
biorxiv.org/content/10.1101/2024.12.13.628416v1
We explored protein translation regulation in early embryo development using C. elegans as our model. #DevBio #CElegans 1/3"