ZANIN LAB

Alle Studierende und Beschäftigte aus NAT und PHIL sollten morgen zu den Krisenversammlungen gehen und sich für eine bessere Gebäudesituation an der FAU einsetzen!

Congratulations to Tamara and Alina! 🫶🏻🎊🎉🥳

It was a pleasure to contribute to the story.

If you want to learn more about how the shape and mechanical properties of centrosomes are regulated during mitosis - a must read.

Sophia won the poster prize at the @dgz.bsky.social meeting in Heidelberg. Congratulations! 🎉 🥳 😀

If you want to know more about this work check out our preprint:
www.biorxiv.org/content/10.1...

Also thanks to the organizers for this great meeting!

Stop by at the two lab posters at the @dgz.bsky.social Meeting in Heidelberg!
Esther will present Mikhail’s work on asymmetric furrow ingression and Sophia on a novel signaling pathway that positions the cleavage furrow at the right place.

Don't miss the 'Mitosis and Meiosis' workshop organized by simonereber.bsky.social & Thomas Mayer !

Joyful day for the lab! 🎉 🥳💫🍻
Fritzi defended her PhD thesis with outstanding honors.
Congratulations on this amazing thesis!

Here is a list of some of her projects:
onlinelibrary.wiley.com/doi/full/10....
pubs.acs.org/doi/10.1021/...
www.cell.com/cell-reports...
www.biorxiv.org/content/10.1...

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of animal model systems, including embryos of mamm...

📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here: www.biorxiv.org/content/10.1...

Deeply honored that our story was chosen for the cover!
🎉 💫🧬

The Dube Lab is on Bluesky! Welcome! 🤗

Congratulations to the Dammermann lab ! Interesting study!

Want to learn more about our work on Anillin during cytokinesis? Check out the Spotlight from the Hickson Lab!

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and #cytokinesis completion. New study from Kuheli Adhikary, Sukriti Kapoor, and Sachin Kotak (Indian Institute of Science Bangalore): rupress.org/jcb/article/...

#Development #CellDivision #Celegans

We are excited to share our latest work on the role of anillin during unilateral cytokinesis. Congratulations to Mikhail, the leading author, for his excellent work. Big thanks to the @tdvalilab.bsky.social lab for their tremendous support.

From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa The human pathogen Pseudomonas aeruginosa is particularly notorious for its multiple resistance mechanisms. A new concept for anti-infectives is the “pathoblocker” approach, which targets virulence factors to disarm rather than kill pathogens and thus attenuates the development of resistance. Based on the estrogen receptor modulator raloxifene, which had previously been identified as a potential biosynthesis inhibitor of the virulence factor pyocyanin via in silico screening, analogues have been developed as pathoblockers against P. aeruginosa. These compounds reduce the production of pyocyanin by binding to the phenazine biosynthesis enzyme PhzB. Structure–activity relationships (SAR) were explored using nano differential scanning fluorimetry, isothermal titration calorimetry, and 12 X-ray cocrystal structures. Compared to raloxifene, congener 20c shows a 60-fold lower affinity for the human estrogen receptor with a 15-fold increase in pyocyanin inhibitory activity. The comprehensive structural information gathered in this study paves the way for the development of improved pathoblockers with increased potency and selectivity.

Happy that we could contribute to the story:
From Bones to Bugs: Structure-Based Development of Raloxifene-Derived Pathoblockers That Inhibit Pyocyanin Production in Pseudomonas aeruginosa | Journal of Medicinal Chemistry pubs.acs.org/doi/full/10....

Poster with DGZ 2025 Meeting details (speakers list, organizers, sponsors)

We are excited to announce the details for this year’s #DGZ International Meeting, a very special one as we are celebrating 50 years of DGZ! Join us in October in Heidelberg, where the DGZ was founded in 1975. Check the speakers line-up etc. at the poster. Registration: shorturl.at/EHUzb #DGZ50

#TeamTomo visits the centrosome. I remember the centrosome and PCM being one of Julia's first targets when we were postdocs together at @mpibiochem.bsky.social. It's cool seeing the progress here in worms with Jeff. Beautiful #CryoET across the cell cycle. @centriolelab.bsky.social take a look! 🧪🧶🧬

Today I will present our work on Anillin function during unilateral cytokinesis at @ascbiology.bsky.social meeting in San Diego.

Getting ready to pregame @ascbiology.bsky.social with an epic reunion of the Oegema/Desai lab @odlab.bsky.social. Can’t wait to see everyone. Can’t believe it’s been 22 years since they started it all.

Please join two sessions of the 8th Frontiers in Cytokinesis Subgroup on Sunday Dec 15 at #cellbio2024!

A new manuscript by @tdvalilab.bsky.social investigates how centrosomes get their spherical shape. They show that PCMD-1, a centriolar protein, is very important for centrosome shape. We are happy that we could contribute to this work!

PCMD-1 stabilizes the PCM scaffold and facilitates centriole separation Centrosomes are highly dynamic organelles, and maintaining their stability is crucial for spindle pole integrity and bipolar spindle formation. Centrosomes consist of a pair of centrioles surrounded b...

Congrats to Alina and the team 🎉🎉🎉!!!!! @zaninlab.bsky.social Check out our latest manuscript -> PCMD-1 stabilizes the PCM scaffold and facilitates centriole separation www.biorxiv.org/content/10.1...

Our group is looking for a technician with experience in S2 bacterial culture and/or cell culture.

Are you interested to join our research group and support our work on novel treatment options against bacterial infections (www.pharmbio.nat.fau.de)?

Please apply through FAU job portal 👇
Please RT

Join lab as a PhD student to study cell division in C. elegans! More details see below...

Great opportunity for postdocs: Call for open topic applications to establish a junior research group in the Department of Biology @unifau.bsky.social.

More information at: www.biology.nat.fau.eu/2024/02/06/o...

Exciting Opportunity! Join us as a professor in Membrane Biochemistry at @unifau.bsky.social! Seeking a passionate membrane enthusiast to explore how membrane functions intertwine with their composition, structure, organization, and dynamics. Apply by Feb 29, 2024:
fau.eu/people/worki...
Please RT!

Dynein directs prophase centrosome migration to control the stem cell division axis in the developin... Abstract. The microtubule motor dynein is critical for the assembly and positioning of mitotic spindles. In C. elegans, these dynein functions have been extensi

A cool story by Reto Gassmann's lab on how dynein controls tissue morphogenesis in a developing animal!

academic.oup.com/genetics/adv...

We are very proud that our collaborative project with the Dube group on rhodanine-based photoswitches was just published in JACS!

pubs.acs.org/doi/abs/10.1...