Craig Gedye

YouTube video by thewhitlamsofficial The Whitlams - Blow Up The Pokies (Official Video)

One more of my votes for the #Hottest100 #TripleJ in the #Hottest200 today... The Whitlams - Blow Up The Pokies www.youtube.com/watch?v=7B49..., still as relevant today www.theguardian.com/australia-ne...

Question remains, is the abscopal effect real? Or is #RT just additive? Certainly evidence for modifying TME, intriguing data for WNT-mt patients when adding #radiotherapy to #PD1 #immunotherapy, but the idea of #RT being a 'vaccine', expanding the immune repertoire, is shown in just 1-2 patients.

The Renal IGW is fast approaching. Concept submissions close in 1 week!
Register your attendance here anzup.org.au/idea-generat...
@craiggedye.bsky.social

Two opinions that to my surprise are either unpopular or not widely held:
1. The control arm of a randomised trial should be best standard of care.
2. A PFS benefit against an inactive comparator is not a major advance, if progressive disease is required for eligibility.

FDA draft guidance outlines appropriate use of tissue biopsies in clinical trials When are tissue biopsies really needed in clinical trials of medical products? Draft guidance from the US Food and Drug Administration (FDA) offers recommendations for weighing the risks and benefits ...

3. Despite ASCO (ascopubs.org/doi/full/10....) and FDA (www.raps.org/news-and-art...) statements that it is unethical to stick large needles into people suffering cancer, many sponsors seem to want to shove large needles into people suffering cancer; for what? To make pretty pictures for a poster?

Great kickoff to clinical trials workshop #ANZUP25 — #MelissaLeMesurier w patient perspective and #ChrisGianacas biostats on collaborative efforts for clinical trials. Same global themes for clinical trial development. @anzuptrials.bsky.social @craiggedye.bsky.social @profiand.bsky.social

Tremendous insights with immediate patient impact; using genomic data we can collect routinely from today's patients, we may be able to predict upfront resistance, rather than subject people to 3-4 cycles of chemo, and we might also be strategic if we know people have sensitive cancers - bravo!

Bravo. Fantastic news.

Introducing the Medical Evidence Project And the quest to make less dead people

Friends, I have news.

It is very good news.

You'll just have to read it, I'm afraid.

jamesclaims.substack.com/p/introducin...

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss t...

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies
www.nature.com/articles/s41...

9News - Latest news and headlines from Australia and the world Latest news and headlines from Australia and the world

Meet Cherrie, one of the earliest participants in the CHALLENGE trial, and my colleague Janette Vardy talking about what these results mean.

www.9news.com.au/videos/natio...

Very good news!

Presenting at #ASCO25 today!
I was expecting to find evidence that oncologists prefer more-lucrative treatments, and was surprised by our results! Clinical benefit matters, drug profit did not.
Cc @dusetzinas.bsky.social

This is hard to digest...

*shared with permission. And thanks to #Telstra for mobile phone coverage in the Australian wilderness!

Thanks again Gauthier Bouche and the @AnticancerFund for support, Tom van der Hulle, Amy Rieborn and the team at @unileiden.bsky.social University Medical Center our collaborators and our site @iconcancercentre.bsky.social

Learn more about the #ANZadapt trial here anzup.org.au/wp-content/u...

So grateful for all the volunteer participants in this crucial clinical trial of #adaptive #evolutionary therapy, and so grateful that we can run an important clinical trial without running people ragged with hospital visits.

#Teletrials in action: a generous and kind participant called me this week for Visit #3 of his participation in @anzuptrials.bsky.social #ANZadapt #clinicaltrial. “Where are you?”, I asked. “Let me send you a photo”, he said. How’s the serenity…

🚨 Public consultations now open: help shape how medicine information is shared with patients.

We are reviewing the template used for EU package leaflets. Have your say on how to make them more understandable and relevant to patients.

🔗 Learn more & share your input:
europa.eu/!TCm47q

Excellent, thought-provoking presentation by Deb Maskens of IKCC on the % of patients that are not being reached by #KidneyCancer organisations and strategies to consider on how we can improve. #IKCC25 @debmaskens.bsky.social

And what about those Phillip Island little penguins... they used to be called FAIRY penguins... enough said... +10%. www.penguins.org.au

Safe travels and thank you for the ongoing good works.

Welcome @myesmo.bsky.social!

https://www.nejm.org/doi/full/10.1056/NEJMoa1917338

https://ourworldindata.org/hpv-vaccination-world-can-eliminate-cervical-cancer

It gets better; vaccination is preventing cancers! Take the incredible example of HPV vaccination for cervical cancer prevention; if we can offer protection to everyone around the world, we could prevent suffering and death for millions of people. And reduce oral and other cancers too!

https://ourworldindata.org/grapher/share-of-population-with-cancer-vs-median-age?time=2021

An opportunity to engage. This is 'half of the truth'. Cancers have gone up since vaccination... because we are living longer on average! Long enough to be at risk for cancer, because children don't die of measles, diptheria, polio etc. Compare incidence in high vs LMIC. ourworldindata.org/cancer

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00513-8/fulltext

Great piece from Lancet Global Health on democratising clinical trials research to strengthen primary healthcare, relevant to ALL healthcare. Every healthcare intervention is a clinical trial of n = 1; why not learn from every patient, every clinician?

Too soon...

Psych. Science just published a paper showing that the "warm glow" of donations can reduce depressive symptoms (d = [0.19, 0.46]).

Most impressively, "micro" donations (one Chinese cent, or $0.0014) appear sufficient to trigger these large effects.

Big if true? Let's dive in.

Reminds me of the 'Duration of Response" endpoint aka magic trick in oncology. Look! Look! In the fraction of people in whom drug XYZ worked (at least for a while...) the cancer didn't grow again (at least for a while...). Winners be winning! Hooray! Can I haz reimbursement plz?