We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... π§΅ 1/6
31.07.2025 06:27 β π 13 π 6 π¬ 1 π 0@kezc.bsky.social
Lecturer in cancer bioinformatics at Cardiff University. https://github.com/kcleal
We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... π§΅ 1/6
31.07.2025 06:27 β π 13 π 6 π¬ 1 π 0Nice work! Do you think it would be hard to calculate perplexity for short read data?
03.07.2025 07:05 β π 0 π 0 π¬ 1 π 0New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
02.07.2025 23:46 β π 55 π 22 π¬ 2 π 0Thank you, Francisco π
26.06.2025 21:08 β π 1 π 0 π¬ 0 π 0Thanks Wales Bioinformatics Network π
26.06.2025 16:13 β π 1 π 0 π¬ 0 π 0π¨ Our GW paper is out in Nature Methods!π₯²
GW is a fast genomics browser (up to 100x faster!)
github.com/kcleal/gw
Also, just released a Python interface for GW
github.com/kcleal/gwplot
π nature.com/articles/s4159β¦
#Genomics #Bioinformatics
Very impressive work π
10.04.2025 16:22 β π 1 π 0 π¬ 0 π 0A really useful resource
08.04.2025 07:49 β π 3 π 2 π¬ 0 π 0@adbeggs.bsky.social Hi Andrew. Fantastic talk today at the WCRC conference! It was very inspiring π
03.03.2025 19:13 β π 1 π 0 π¬ 1 π 0π§¬π₯οΈ Just released Dysgu v1.8 which now supports phasing of structural variants when using long reads. Makes SV calling much more sensitive - see PacBio benchmark π github.com/kcleal/SV_Be... dysgu repo github.com/kcleal/dysgu...
26.02.2025 11:37 β π 8 π 4 π¬ 0 π 0π§¬π₯οΈ Sharing an update to my SV benchmark repo. More callers have been added for the CMRG/GIAB benchmarks. github.com/kcleal/SV_Be.... Also now uses #Nextflow and tests the newest #PacBio Vega data, along with #ONT kit14. Results are on the GitHub page π
29.11.2024 13:40 β π 11 π 2 π¬ 2 π 0𧬠π₯οΈ
18.11.2024 20:22 β π 0 π 0 π¬ 0 π 0Also my first foray into rust land - lots to like I have to say!
18.11.2024 16:39 β π 0 π 0 π¬ 0 π 0Hi all. Just released a fast library (C++/Rust/Python) for performing interval intersections. Uses a novel superset-index that tends to be faster than current libs, and also has a SIMD accelerated counting algorithm π github.com/kcleal/super...
18.11.2024 15:44 β π 18 π 5 π¬ 4 π 0Thanks π Could I be added? Cheers
12.11.2024 21:57 β π 0 π 0 π¬ 1 π 0Whole genome in 2s π wowπ
12.11.2024 21:20 β π 1 π 0 π¬ 1 π 0Hi @robp.bsky.social, not sure if I qualify, but could I be added to the list? Cheers π
12.11.2024 16:02 β π 1 π 0 π¬ 1 π 0I made a starter pack for algorithmic genomics. It's certainly incomplete, but already has a ton of awesome peeps. Let me know if you know people I should add (with a focus on algorithms and data structures in genomics)
go.bsky.app/TRWCnZs
BioNumpy looks really good, looking forward to giving this a try www.nature.com/articles/s41...
11.11.2024 19:05 β π 1 π 1 π¬ 0 π 0I created a genomics+bioinformatics starter pack. If I left you off, *please* reply and I'll add you! go.bsky.app/B5YYBfq
22.10.2024 12:34 β π 176 π 106 π¬ 99 π 7Hello world! This looks promising
13.09.2023 22:44 β π 4 π 0 π¬ 0 π 0