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Kez Cleal

@kezc.bsky.social

Lecturer in cancer bioinformatics at Cardiff University. https://github.com/kcleal

739 Followers  |  665 Following  |  19 Posts  |  Joined: 13.09.2023  |  2.0873

Latest posts by kezc.bsky.social on Bluesky

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Tumor clone dynamics in gastro-esophageal cancer organoids reveal a non-genetic memory of neoadjuvant chemotherapy via downregulation of NFΞΊB signaling Adenocarcinomas of the gastroesophageal junction exhibit genetic and non-genetic heterogeneity that impact clinical outcomes, though the underlying mechanisms behind drug resistance remain poorly unde...

We are happy to present a new paper on gastric tumour evolution in response to peri-operative chemotherapy. www.biorxiv.org/content/10.1... 🧡 1/6

31.07.2025 06:27 β€” πŸ‘ 13    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0

Nice work! Do you think it would be hard to calculate perplexity for short read data?

03.07.2025 07:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Perplexity as a Metric for Isoform Diversity in the Human Transcriptome Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...

New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...

02.07.2025 23:46 β€” πŸ‘ 55    πŸ” 22    πŸ’¬ 2    πŸ“Œ 0

Thank you, Francisco πŸ™

26.06.2025 21:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Thanks Wales Bioinformatics Network πŸ™‚

26.06.2025 16:13 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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GitHub - kcleal/gw: Genome browser and variant annotation Genome browser and variant annotation. Contribute to kcleal/gw development by creating an account on GitHub.

🚨 Our GW paper is out in Nature Methods!πŸ₯²

GW is a fast genomics browser (up to 100x faster!)
github.com/kcleal/gw

Also, just released a Python interface for GW
github.com/kcleal/gwplot

πŸ“ nature.com/articles/s4159…

#Genomics #Bioinformatics

26.06.2025 14:47 β€” πŸ‘ 38    πŸ” 17    πŸ’¬ 2    πŸ“Œ 0

Very impressive work πŸ‘

10.04.2025 16:22 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

A really useful resource

08.04.2025 07:49 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

@adbeggs.bsky.social Hi Andrew. Fantastic talk today at the WCRC conference! It was very inspiring πŸ‘

03.03.2025 19:13 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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🧬πŸ–₯️ Just released Dysgu v1.8 which now supports phasing of structural variants when using long reads. Makes SV calling much more sensitive - see PacBio benchmark πŸ‘‰ github.com/kcleal/SV_Be... dysgu repo github.com/kcleal/dysgu...

26.02.2025 11:37 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Post image 29.11.2024 14:49 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Post image 29.11.2024 14:48 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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GitHub - kcleal/SV_Benchmark_CMRG_GIAB: Structural variant benchmark of challenging medically relevant genes Structural variant benchmark of challenging medically relevant genes - kcleal/SV_Benchmark_CMRG_GIAB

🧬πŸ–₯️ Sharing an update to my SV benchmark repo. More callers have been added for the CMRG/GIAB benchmarks. github.com/kcleal/SV_Be.... Also now uses #Nextflow and tests the newest #PacBio Vega data, along with #ONT kit14. Results are on the GitHub page πŸ‘‰

29.11.2024 13:40 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0

🧬 πŸ–₯️

18.11.2024 20:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Also my first foray into rust land - lots to like I have to say!

18.11.2024 16:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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GitHub - kcleal/superintervals: Fast interval intersection library Fast interval intersection library. Contribute to kcleal/superintervals development by creating an account on GitHub.

Hi all. Just released a fast library (C++/Rust/Python) for performing interval intersections. Uses a novel superset-index that tends to be faster than current libs, and also has a SIMD accelerated counting algorithm πŸ‘‡ github.com/kcleal/super...

18.11.2024 15:44 β€” πŸ‘ 18    πŸ” 5    πŸ’¬ 4    πŸ“Œ 0

Thanks πŸ‘ Could I be added? Cheers

12.11.2024 21:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Whole genome in 2s πŸ˜‚ wowπŸ‘

12.11.2024 21:20 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hi @robp.bsky.social, not sure if I qualify, but could I be added to the list? Cheers πŸ‘

12.11.2024 16:02 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I made a starter pack for algorithmic genomics. It's certainly incomplete, but already has a ton of awesome peeps. Let me know if you know people I should add (with a focus on algorithms and data structures in genomics)

go.bsky.app/TRWCnZs

12.11.2024 14:03 β€” πŸ‘ 141    πŸ” 65    πŸ’¬ 25    πŸ“Œ 2
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BioNumpy looks really good, looking forward to giving this a try www.nature.com/articles/s41...

11.11.2024 19:05 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Genomics+Bioinformatics Starter Pack 🧬πŸ–₯️ Join the conversation

I created a genomics+bioinformatics starter pack. If I left you off, *please* reply and I'll add you! go.bsky.app/B5YYBfq

22.10.2024 12:34 β€” πŸ‘ 176    πŸ” 106    πŸ’¬ 99    πŸ“Œ 7

Hello world! This looks promising

13.09.2023 22:44 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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